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Monomethylauristatin F (MMAF)
Orukọ Kemikali: (S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-dimethyl-2-( (S) -3-methyl-2- (methylamino) butanamido) butanamido) -3-methoxy-5-methylheptanoyl) pyrrolidin-2-yl) -3-methoxy-2-methylpropanamido) -3-phenylpropanoic acid Iwọn Molecular: 731.96 Formula: C39H65N5O8 CAS #: 141205-32-5 Solubility: DMSO to 20 mM Iṣẹ-ṣiṣe Biological Monomethyl auristatin F (MMAF) tabi desmethyl-auristatin F jẹ aṣoju-tubulin ti o dẹkun pipin polymer tubulin. O jẹ... -
Monomethyl Auristatin E (MMAE)
Orukọ Kemikali: (S)-N-((3R,4S,5S)-1-((S)-2-(1R,2R)-3-((1S,2R)-1-hydroxy-1-phenylpropan-2 -yl) amino)-1-methoxy-2-methyl-3-oxopropyl) p yrrolidin-1-yl) -3-methoxy-5-methyl-1-oxoheptan-4-yl) -N,3-dimethyl-2-((S) -3-methyl-2- (methylamino) butanamido) butanamide Iwọn Molecular: 717.98 Formula: C39H67N5O7 CAS: 474645-27-7 Solubility: DMSO to 20 mM Monomethyl Auristatin E jẹ ohun itọsẹ dolastatin-10 peptide ti o ni agbara pẹlu iṣẹ antimitotic ti o lagbara ati iṣẹ-ṣiṣe antineoplastic ti o pọju gẹgẹbi apakan ti ẹya-ara ti antineoplastic.