Orukọ Kemikali:(S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-dimethyl-2-((S) -3-methyl-2- (methylamino) butanamido) butanamido) -3-methoxy-5-methylheptanoyl) pyrrolidin-2-yl) -3-methoxy-2-methylpropanamido) -3-phenylpropanoic acid

Ìwọ̀n Molikula:731.96
Fọọmu:C39H65N5O8
CAS#:141205-32-5
Solubility:DMSO to 20 mM

Ti ibi aṣayan iṣẹ-ṣiṣe
Monomethyl auristatin F (MMAF) tabi desmethyl-auristatin F jẹ aṣoju egboogi-tubulin ti o ṣe idiwọ pipin sẹẹli nipa didi polymerization ti tubulin. O jẹ tuntunauristatin itọsẹpẹlu idiyele C-terminal phenylalanine ti o dinku iṣẹ ṣiṣe cytotoxic rẹ ni akawe si ẹlẹgbẹ ti ko gba agbara, monomethyl auristatin E (MMAE). Ni afikun, ẹgbẹ N-terminal amino ni nikanọkanaropo methyl dipo meji bi ninuauristatin Ffunrararẹ.