Igama Lekhemikhali: (S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2 -yl)amino) -1-methoxy-2-methyl-3-oxopropyl)p yrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide
Isisindo se-molecule: 717.98
Ifomula: C39H67N5O7
I-CAS: 474645-27-7
Ukunyibilika: DMSO kufika ku-20 mM

I-Monomethyl Auristatin E yi-aI-dolastatin-10okuphuma kwe-peptide okunomsebenzi onamandla we-antimitotic kanye nomsebenzi ongase ube khona we-antineoplastic njengengxenye ye-antibody-drug conjugate (ADC). I-Monomethyl auristatin E (MMAE) ibophezela ku-tubulin, ivimba i-tubulin polymerization, futhi ivimbele ukwakheka kwe-microtubule, okuholela kukho kokubili ukuphazamiseka kokuhlangana kwe-mitotic spindle kanye nokuboshwa kwamaseli wesimila esigabeni esingu-M somjikelezo weseli. Ukunciphisa ubuthi futhi kwandise ukusebenza kahle,MMAEihlanganiswa, ngesixhumi se-peptide esihlukanisekayo, ku-antibody eyi-monoclonal eqondise ngokuqondile isimila sesiguli. Isixhumanisi sizinzile endaweni engaphandle kwamaseli kodwa sigoqeka kalula ukuze sidedelweMMAEkulandela ukubophezela nokufakwa ngaphakathi kwe-ADC ngamaseli okuqondiwe.