Igama Lekhemikhali:(S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-dimethyl-2-((S) -3-methyl-2-(methylamino)butanamido)kodwa i-anamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoic i-asidi

Isisindo se-Molecular:731.96
Ifomula:I-C39H65N5O8
I-# ye-CAS:141205-32-5
Ukunyibilika:I-DMSO kufika ku-20 mM

Umsebenzi Webhayoloji
I-Monomethyl auristatin F (MMAF) noma i-desmethyl-auristatin F iyi-ejenti ye-anti-tubulin evimbela ukuhlukana kwamaseli ngokuvimbela i-polymerization ye-tubulin. Yintshai-auristatin okuphuma kokunyeene-C-terminal phenylalanine ekhokhiswayo enciphisa umsebenzi wayo we-cytotoxic uma iqhathaniswa nozakwabo ongakhokhisiwe, i-monomethyl auristatin E (MMAE). Ngaphezu kwalokho, iqembu le-amino le-N-terminal linakho kuphelaeyodwaesikhundleni se-methyl esikhundleni sokubili njenge-ini-auristatin Fuqobo.