Igama lamakhemikhali:(S) -2 - (2r, 3r) -3 - ((s) -1 - ((3r, 4s, 5s)-4 - ((s) -3-methyl-2- (methylamino) butanamido) kodwa Anamido) -3-Methoxy-5-methylphetholanoyl) pyrlolidin-2-yl) -3-methoxy-2-methylpropanamido) -3-phenylpropanoic -muncu

Isisindo samangqamuzana:731.96
Ifomula:C39h65n5o8
Case #:141205-32-5
I-Solubity:DMSO ufinyelela ku-20 mm

Umsebenzi wemvelo
Monomethyl auristatin f (MMAF) noma Desmethyl-Auristatin F iyi-ejenti ye-anti-tubulin evimbela ukuhlukaniswa kweseli ngokuvimba i-polymerization ye-tubulin. Kuyinto entshaauristatin okokusulwaNge-Phenylalanine ekhokhisiwe ye-C-terminal efaka umsebenzi wayo we-cytotoxic uma iqhathaniswa nomlingani wayo ongalawulwa, i-monomethyl auristatin e (MMAE). Ngaphezu kwalokho, i-Amino Group ye-N-terminal ine-okukodwaI-methyl inqume esikhundleni sababili njengasekuqaleniauristatin fuqobo.