1ml: 4μg / 1ml: 15μg Amandla

Isalathiso:

IZIbonakaliso NOKUSETYENZISWA

I-Hemophilia A: I-Desmopress kwi-Acetate Injection 4 mcg / mL iboniswa kwizigulane ezine-hemophilia A kunye ne-factor VIII i-coagulant ye-coagulant inqanaba lomsebenzi ngaphezu kwe-5%.

I-Desmopress kwinaliti ye-acetate iya kuhlala igcina i-hemostasis kwizigulane ezine-hemophilia A ngexesha leenkqubo zotyando kunye nasemva kokuhlinzwa xa kulawulwa imizuzu engama-30 ngaphambi kwenkqubo ecwangcisiweyo.

I-Desmopress kwinaliti ye-acetate iyakuyeka ukopha kwi-hemophilia A izigulana ezineziqephu zokwenzakala okuzenzekelayo okanye okubangelwa yintlungu efana ne-hemarthroses, i-hematomas ye-intramuscular okanye ukopha kwe-mucosal.

I-Desmopress kwinaliti ye-acetate ayiboniswanga kunyango lwe-hemophilia A ene-factor VIII amanqanaba omsebenzi we-coagulant alingana okanye ngaphantsi kwe-5%, okanye kunyango lwe-hemophilia B, okanye kwizigulane ezine-factor VIII antibodies.

Kwiimeko ezithile zeklinikhi, kunokuba kulungele ukuzama i-desmopress kwi-injection ye-acetate kwizigulane ezinezinga le-factor VIII phakathi kwe-2% ukuya kwi-5%; nangona kunjalo, ezi zigulane kufuneka zibekwe esweni ngononophelo. I-von Willebrand's Disease (Uhlobo I): I-Desmopres s kwinaliti ye-acetate i-4 mcg/mL iboniswa kwizigulane ezine-mild to moderate classic von's disease (Uhlobo I) kunye namanqanaba e-factor VIII angaphezu kwe-5%. I-Desmopress kwinaliti ye-acetate iya kuhlala igcina i-hemostasis kwizigulane ezine-von Willebrand's disease encinci ukuya kwimodareyitha ngexesha leenkqubo zotyando kunye nasemva kokuhlinzwa xa kulawulwa imizuzu engama-30 ngaphambi kwenkqubo ecwangcisiweyo.

I-Desmopress kwinaliti ye-acetate idla ngokuyeka ukopha kwizigulane ze-von Willebrand ezineziqephu zokwenzakala okuzenzekelayo okanye okubangelwa yintlungu efana ne-hemarthroses, i-hematomas ye-intramuscular okanye ukopha kwe-mucosal.

Ezo zigulana zesifo sika-von Willebrand ezingafane ziphendule zezo zine-homozygous ye-von Willebrand isifo esine-factor VIII coagulant kanye ne-factor VIII von.

Willebrand factor antigen amanqanaba angaphantsi kwe-1%. Ezinye izigulana zinokuphendula ngendlela eyahlukileyo ngokuxhomekeke kuhlobo lwesiphene semolekyuli abanaso. Ixesha legazi kunye ne-factor VIII coagulant activity, ristocetin cofactor activity, kunye ne-von Willebrand factor antigen kufuneka ihlolwe ngexesha lolawulo lwe-desmopress kwi-injection ye-acetate ukuqinisekisa ukuba amanqanaba afanelekileyo ayafezekiswa.

I-Desmopress kwinaliti ye-acetate ayiboniswa kunyango lwe-classic von Willebrand's disease (Uhlobo I) kwaye xa kukho ubungqina bemo engaqhelekanga ye-molecular form of factor VIII antigen.

I-Diabetes Insipidus: I-Desmopress kwi-acetate injection 4 mcg / mL iboniswa njengonyango lokutshintshwa kwe-antidiuretic ekulawuleni i-central (cranial) ye-diabetes insipidus kunye nokulawulwa kwe-polyuria yesikhashana kunye ne-polydipsia emva kokulimala kwentloko okanye utyando kwingingqi ye-pituitary.

I-Desmopress kwinaliti ye-acetate ayisebenzi kunyango lwe-nephrogenic diabetes insipidus.

I-Desmopress kwi-acetate iyafumaneka njengolungiselelo lwe-intranasal. Nangona kunjalo, le ndlela yokuhambisa inokuthi ithotyelwe zizinto ezahlukeneyo ezinokuthi zenze ukuba ukuphefumula ngeempumlo kungasebenzi okanye kungafanelekanga.

Ezi ziquka ukufunxa kakubi kwi-intranasal, ukuxinana kweempumlo kunye nokuvaleka, ukukhutshwa kweempumlo, i-atrophy ye-mucosa yeempumlo, kunye ne-atrophic rhinitis enzima. Ukuhanjiswa kwangaphakathi kweempumlo kunokungafanelekanga apho kukho inqanaba lokuphazamiseka kwengqondo. Ukongeza, iinkqubo zotyando lwe-cranial, ezifana ne-transsphenoidal hypophysectomy, zenza iimeko apho enye indlela yokulawula iyadingeka njengakwiimeko zokupakishwa kweempumlo okanye ukubuyiswa kotyando.

IZITHINTELO

I-Desmopress kwi-acetate injection 4 mcg / mL ichasene nabantu abane-hypersensitivity eyaziwayo kwi-desmopress kwi-acetate okanye nakweyiphi na icandelo le-desmopress kwi-acetate injection 4 mcg / mL.

I-Desmopress kwi-acetate injection inqatshelwe kwizigulane ezinokukhubazeka okuphakathi ukuya kwi-renal enzima (echazwe njenge-creatinine clearance ngaphantsi kwe-50ml / min).

I-Desmopress kwinaliti ye-acetate ichasene nezigulane ezine-hyponatremia okanye imbali ye-hyponatremia.