I-Bintaliridininaliti

I-250mg / amandla e-vial

Isalathiso:I-BintaliridinIboniswe ukuba isetyenziswe njenge-anticouhlant kwizigulana ezingena ngaphakathi kongenelelo lwe-coroncaneaus (PCI).

Isicelo sekliniki: Isetyenziswe kwinaliti ye-inaliti ye-intravenous.

Izalathiso kunye nokusetyenziswa

1.1 I-Percutaneous eTransluminal Angioplasty (PTCA)

I-chacalilirin yenaliti iboniswe ukuba isetyenziswe njenge-anticouhlant kwizigulana ezingenathemba i-angina engafunekiyo i-procutaneal eguqulelayo i-Angioplasty ye-Angioplasty (PTCA).

1.2 Ungenelelo lwe-coroncaneaneus (PCI)

I-BintalIridin yenaliti ngokusetyenziswa okwethutyana kwe-Glycoprotein ye-IIB / IIA

Ukubuyiselwa kwetyala-2 kuboniswe ukusetyenziswa njenge-anticoursurhel kwizigulana ezingenelelo zongenelelo lweNkampani (PCI).

I-chalicalidudin yenaliti iboniswe kwizigulana, okanye emngciphekweni we, i-heparin ye-heparin ikhuphe i-himbacytopenia (hit) okanye i-heparin ye-hemparin inesifo se-thrimbosme (i-hitts) i-PCI.

1.3 e-US e nge-aspirin

I-chalicalidin yenaliti kwezi zikhombisi zenzelwe ukuba isetyenziswe nge-Aspirin kwaye ifundwe kuphela kwizigulana ezifumana i-aspirin ye-aspirin.

1.4 UKUSETYENZISWA KOKUSETYENZISWA

Ukhuseleko kunye nokusebenza kwe-bilicadin ukuze inaliti ayisekwa kwizigulana ezine-syrodomes ye-ackere ezingeyiyo i-PTCA okanye iPCI.

I-2 dosage nolawulo

2.1 I-DESE icebiso

I-BintalIridin ye-inaliti yeyokuphazamiseka kwe-intravenous kuphela.

I-BintalIridin ye-inaliti yenzelwe ukuba isetyenziswe nge-aspirin (i-300 ukuya kwi-325 mg mihla le) kwaye ifundwe kuphela kwizigulana ezifumana i-aspirin efumana i-aspirin ye-aspirin.

Kwizigulana ezingakhange zibethe / ukubetha

Idosi ecetyiswayo ye-bilicadin ye-Inaliti yi-Inravenous Imizuzu emihlanu emva kokuba i-bos ye-bolus ilawulwa, ixesha elisebenzayo (umThetho) kufuneka lwenziwe kwaye i-bors eyongezelelweyo ye-0.3 mg / kg kufuneka inikwe ukuba iyafuneka.

Ulawulo lwe-GPI kufuneka luqwalaselwe kwimeko yokuba nayiphi na imeko edweliswe kwindawo yokuvavanywa kwe-2 yeklinikhi yangoku.

Kwizigulana ezibethile / zokubetha

Idosi ecetyiswayo ye-bilicadin ye-inaliti kwizigulana ezine-hit / hitts i-PCI yi-iV bolus ye-0.75 mg / kg / kg / kg. Oku kuya kulandelwa kukufakwa okuqhubekayo ngexabiso le-1.75 mg / kg / h ngexesha lenkqubo.

Kwinkqubo yePosi eqhubekayo

I-bilicalidin yokufakwa kwenaliti inokuqhubeka nokulandela iPCI / PTCA ukuya kuthi ga kwiiyure ezi-4 zeposi malunga nogqirha onyango.

Kwizigulana ezine-ST Seughtion i-Intocardial inveloction (STEMI) Ukuqhubeka kwe-bilicadin ye-injenion ye-Inaliti kwi-1.75 MG / kg / i-PTCA / i-PCE / i-PTI / ye-PTCA / i-PTCA yenkqubo ye-PAT-ndlela kufuneka ithathelwe ingqalelo kumngcipheko weTrambosis.

Emva kweeyure ezine, ukuncitshiswa kwe-IV eyongezelelweyo ye-bitywayo ye-Inaliti inokuqaliswa nge-0.2 mg / kg / h (ukuya kuthi ga kwiiyure ezingama-20, ukuba kuyafuneka.

2.2 i-dosing ekufikeni kweRenal

Akukho kuncitshiswa kwi-bos ye-boul ifuneka kulo naliphi na inqanaba lokuphazamiseka kweRenal. Idosi ye-infaware ye-chalicadin ukuze inaliti inokufuna ukuncitshiswa, kwaye imeko ye-anticouhlala ijongiwe kwizigulana ezinobungozi. Izigulana ezinobungozi obuphakathi (nge-30 ukuya kwi-59 ml / min) kufuneka zifumane ukuthambeka kwe-1.75 mg / kg / h. Ukuba i-creayinine ilahleko ingaphantsi kwe-30 ml / min, ukuncitshiswa kwenqanaba le-insulion ukuya kwi-1 mg / kg / h kufuneka ithathelwe ingqalelo. Ukuba isigulana sikwi-hemodialysis, izinga lokungafuneki kufuneka lincitshiswe kwi-0.25 mg / kg / h.

Imiyalelo yoLawulo

I-BinalIridin yenaliti yenzelwe inaliti ye-ilravenous ye-inasution kunye nokuhonjiswa okuqhubekayo emva kokuphindaphindeka kwakhona kunye ne-dilution. Kwi-vial vial vial ye-250 mg, yongeza i-5 ml yamanzi amdaka ukuze inaliti, i-USP. Ngobukrelekrele de zonke izinto zichithwe. Okulandelayo, ukurhoxisa kwaye ulahle i-5 ml kwingxowa ye-50 ml ye-50 ml ene-5% dextrase emanzini okanye kwi-0.9% ye-sodium chlorim ye-chlorium ye-chlorium ye-hlorium ye-hlorium ye-chlorim ye-hlorium ye-chlorium ye-hlorim ye-hlorium ye-chlorind ye-hlorium chloride ineenaliti. Emva koko yongeza imixholo ye-vial ye-vial ekhankanyiweyo ngokutsha kwi-5% dextrase emanzini okanye kwi-0.9% yesodium chloride ye-5 mg / ml kwi-50 ml; I-5 vials nge-250 ml). Idosi ukuba ilawulwe ihlengahlengiswa ngokwesisindo sobunzima (jonga kwiTheyibhile 1).

Ukuba i-insulion yexabiso eliphantsi isetyenziswa emva kokufumana i-insulion yokuqala, ibhegi ephantsi yengxoxo kufuneka ilungiswe. Ukwenzela ukulungiselela olu xinzelelo lungaphantsi, cima i-250 mg vial nge-5 ml yamanzi e-sterle ye-inaliti, i-USP. Ngobukrelekrele de zonke izinto zichithwe. Okulandelayo, ukurhoxisa kwaye ulahle i-5 ml kwingxowa ye-500 ye-500 ye-500 ye-5% ye-5% dextrase emanzini okanye kwi-0.9% ye-sodium chlorim ye-hlorium ye-hlorim ye-hlorim ye-hlorim ye-chlorim ye-chlorium ye-hlorim ye-hlorim ye-hlorim ye-chlorim ye-sloride yokufumana inaliti. Emva koko yongeza imixholo ye-vial ye-vial ephindaphindiweyo kwingxowa ye-infaphu equkethe i-5% dextrase emanzini okanye kwi-0.9% ye-sodium chlorium ye-hlorim inyanzelise inaliti ukuvelisa uxinzelelo lokugqibela lwe-0.5 mg / ml. Ireyithi ye-infanoion ukuba ilawulwe kufuneka ikhethwe kwikholam yesekunene kwiTheyibhile 1.