Lebitso la lik'hemik'hale: (S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2 -yl)amino) -1-methoxy-2-methyl-3-oxopropyl) leq yrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide
Boima ba 'mele: 717.98
Tlhaloso: C39H67N5O7
CAS: 474645-27-7
Sollubility: DMSO ho fihla ho 20 mm

Monomethyl Auristatin E ke eadolastatin-10peptide derivative e nang le ts'ebetso e matla ea antimitotic le ts'ebetso e ka bang teng ea antineoplastic e le karolo ea conjugate ea antibody-drug (ADC). Monomethyl auristatin E (MMAE) e tlama ho tubulin, e thibela tubulin polymerization, 'me e thibela ho thehoa ha microtubule, e leng se fellang ka ho senyeha ha kopano ea mitotic spindle le ho tšoaroa ha lisele tsa tumor karolong ea M ea potoloho ea lisele. Ho fokotsa toxicity le ho eketsa ts'ebetso,MMAEe kopanngoa, ka sehokelo sa peptide se qhetsohang, ho ea ho lesole la 'mele la monoclonal le shebileng ka ho khetheha hlahala ea mokuli. Sehokelo se tsitsitse sebakeng sa extracellular empa se ts'oaroa habonolo hore se lokolloeMMAEka mor'a ho tlama le ho kenngoa ka hare ho ADC ke lisele tse lebisitsoeng.