Magaca Kiimikada: (S)-N-((3R,4S,5S)-1-((S)-2-(1R,2R)-3-((1S,2R)-1-hydroxy-1-phenylpropan-2 -yl)amino)-1-methoxy-2-methyl-3-oxopropyl) p yrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino) butanamido) butanamide
Miisaanka Molecular: 717.98
Formula: C39H67N5O7
CAS: 474645-27-7
Solubility: DMSO ilaa 20 mM

Monomethyl Auristatin E waa adolastatin-10peptide derivative oo leh firfircoonida antimitotic awood leh iyo firfircoonida antineoplastic ee suurtogalka ah taas oo qayb ka ah isku-xidhka daawada-antibody-ga (ADC). Monomethyl auristatin EMMAE) waxay ku xidhan tahay tubulin, waxay xannibaysaa polymerization tubulin, waxayna joojisaa samaynta microtubule, taas oo keenta labadaba carqaladaynta isku dhafka lafdhabarta mitotic iyo xiritaanka unugyada burooyinka ee marxaladda M ee wareegga unugyada. Si loo yareeyo sunta oo loo kordhiyo waxtarka,MMAEwaxa lagu xidhaa, iyada oo loo sii marayo isku xidhaha peptide ee la kala furfuri karo, ilaa unug monoclonal antibody kaas oo si gaar ah u bartilmaameedsada buro bukaanka. Xidhiidhiyuhu wuu xasiloon yahay unugga unugga ka baxsan laakiin si diyaar ah ayaa loogu dheggan yahay siidayntaMMAEka dib xidhitaanka iyo gudaha ADC by unugyada bartilmaameedka.