Magaca Kiimikada:(S)-2-((2R,3R)-3-((S)-1-(3R,4S,5S)-4-((S)-N,3-dimethyl-2-((S) -3-methyl-2- (methylamino) butanamido) butanamido -3-methoxy-5-methylheptanoyl) pyrrolidin-2-yl) -3-methoxy-2-methylpropanamido) -3-phenylpropanoic acid

Miisaanka Molecular:731.96
Formula:C39H65N5O8
CAS#:141205-32-5
Xalka:DMSO ilaa 20mM

Waxqabadka Nafleyda
Monomethyl auristatin F (MMAF) ama desmethyl-auristatin F waa wakiilka ka hortagga-tubulin-ka ee joojiya kala-qaybinta unugyada iyada oo xannibaysa polymerization of tubulin. Waa cusubauristatin asaloo leh C-terminal phenylalanine oo lagu soo oogay taas oo hoos u dhigaysa waxqabadkeeda cytotoxic marka la barbardhigo dhiggeeda aan la dallacin, monomethyl auristatin E (MMAE). Intaa waxaa dheer, kooxda amino N-terminal waxay leeyihiin oo kaliyamidmethyl beddelka halkii laba sida inauristatin Flafteeda.