Chemical Name: (S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2 -yl)amino) -1-methoxy-2-methyl-3-oxopropyl)p yrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide
Molecular uremu: 717.98
Nzira: C39H67N5O7
CAS: 474645-27-7
Solubility: DMSO kusvika ku20 mM

Monomethyl Auristatin E ndiye adolastatin-10peptide inobva kune yakasimba antimitotic chiitiko uye inogona kuita antineoplastic chiitiko sechikamu che antibody-drug conjugate (ADC). Monomethyl auristatin E (MMAE) inosungira ku tubulin, inovhara tubulin polymerization, uye inhibits microtubule kugadzirwa, izvo zvinoguma nekukanganiswa kwemitotic spindle assembly uye kusungwa kwebundu masero muM chikamu chesero cycle. Kuderedza toxicity uye kuwedzera kushanda zvakanaka,MMAEinosanganiswa, kuburikidza neinotsemuka peptide linker, kune monoclonal antibody inonangana nebundu remurwere. Iyo linker yakagadzikana mune iyo extracellular milieu asi inonamirwa nyore kusununguraMMAEkutevera kusunga uye kuiswa mukati kweADC nemasero anotarirwa.