Chemical Name:(S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-dimethyl-2-((S) -3-methyl-2-(methylamino)butanamido)asi anamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoic acid
Molecular Weight:731.96
Formula:C39H65N5O8
CAS#:141205-32-5
Solubility:DMSO kusvika ku20 mM
Biological Activity
Monomethyl auristatin F (MMAF) kana desmethyl-auristatin F is anti-tubulin agent iyo inhibits kupatsanurwa kwesero nekuvhara iyo polymerization ye tubulin. Itsvaauristatin derivativeine C-terminal phenylalanine inopomerwa iyo inoderedza basa rayo re cytotoxic kana ichienzaniswa neyo isina kubhadharwa, monomethyl auristatin E (MMAE). Mukuwedzera, iyo N-terminal amino boka rine chetePoshimethyl substituent pachinzvimbo chevaviri as inauristatin Fpacharo.