1ml:4μg / 1ml:15μg Simba

Chiratidzo:

ZVIRATIDZO UYE MASHANDISI

Hemophilia A: Desmopress muAcetate Injection 4 mcg/mL inoratidzwa kune varwere vane hemophilia A ine factor VIII coagulant basa mazinga anopfuura 5%.

Desmopress mujekiseni yeacetate inowanzochengetedza hemostasis kune varwere vane hemophilia A panguva yekuvhiyiwa uye mushure mekuvhiyiwa kana ichiitwa 30 maminetsi isati yarongwa.

Desmopress mune jekiseni reacetate inomisawo kubuda ropa muhemophilia A varwere vane zvikamu zvekukuvara kwakangoerekana kwaitika kana kukuvadzwa-kukonzeresa senge hemarthroses, intramuscular hematomas kana mucosal kubuda ropa.

Desmopress mune jekiseni reacetate hairatidzirwe pakurapa hemophilia A ine factor VIII coagulant nhanho yekuita yakaenzana kana isingasviki 5%, kana kurapwa kwehemophilia B, kana muvarwere vane factor VIII masoja ekudzivirira chirwere.

Mune mamwe mamiriro emakiriniki, zvingave zvakakodzera kuedza desmopress mujekiseni yeacetate kune varwere vane factor VIII mazinga pakati pe2% kusvika ku5%; zvisinei, varwere ava vanofanira kunyatsotariswa. von Willebrand's Disease (Type I): Desmopres s mune acetate jekiseni 4 mcg/mL inoratidzwa kune varwere vane hunyoro kusvika pakati nepakati classic von Willebrand's disease (Type I) ine factor VIII mazinga anopfuura 5%. Desmopress mujekiseni yeacetate inowanzochengetedza hemostasis muvarwere vane chirwere chevon Willebrand chakapfava kusvika pakati-kati panguva yekuvhiya uye mushure mekuvhiyiwa kana ichiitwa maminitsi makumi matatu isati yaitwa.

Desmopress mujekiseni reacetate kazhinji inomisa kubuda ropa mukati mevarwere vevon Willebrand vane zvikamu zvekuzviitira kana kukuvara-kunokonzerwa nekukuvara kwakafanana nehemarthroses, intramuscular hematomas kana mucosal kubuda ropa.

Vaya varwere vechirwere chevon Willebrand avo vangangoita zvishoma kupindura ndeavo vane homozygous yakakomba von Willebrand's chirwere chine factor VIII coagulant chiitiko uye factor VIII von.

Willebrand factor antigen mazinga ari pasi pe1%. Vamwe varwere vanogona kupindura nenzira yakasiyana zvichienderana nerudzi rwechirema chemolecular chavanacho. Nguva yekubuda ropa uye factor VIII coagulant chiitiko, ristocetin cofactor chiitiko, uye von Willebrand factor antigen inofanira kuongororwa panguva yekutonga kwe desmopress mune acetate jekiseni kuti ive nechokwadi chekuti mazinga akakwana ari kuwanikwa.

Desmopress mune jekiseni reacetate hairatidzirwe kurapwa kwechirwere chakanyanya chevon Willebrand (Type I) uye kana paine humbowo hweabnormal molecular form of factor VIII antigen.

Diabetes Insipidus: Desmopress in acetate injection 4 mcg / mL inoratidzwa se antidiuretic replacement therapy muhutungamiri hwepakati (cranial) chirwere cheshuga insipidus uye nokuda kwekutungamirirwa kwepolyuria yenguva pfupi uye polydipsia inotevera kukuvara kwemusoro kana kuvhiyiwa munharaunda yepituitary.

Desmopress mune jekiseni reacetate haishande pakurapa nephrogenic chirwere cheshuga insipidus.

Desmopress mu acetate inowanikwawo sekugadzirira intranasal. Zvisinei, iyi nzira yekuendesa inogona kukanganiswa nezvinhu zvakasiyana-siyana zvinogona kuita kuti kuputika kwemhino kusashande kana kusakodzera.

Izvi zvinosanganisira kusabatwa zvakanaka kwemukati memhino, kusangana kwemhino nekuvharika, kubuda mumhino, atrophy yenasal mucosa, uye yakanyanya atrophic rhinitis. Kusununguka kwemukati memhino kunogona kunge kusina kufanira uko kune kukanganiswa kwemazinga ekuziva. Pamusoro pezvo, kuvhiyiwa kwecranial, senge transsphenoidal hypophysectomy, kunogadzira mamiriro ezvinhu apo imwe nzira yekutungamira inodiwa senge mumhino kurongedza kana kupora kubva pakuvhiyiwa.

CONTRAINDICATIONS

Desmopress muacetate jekiseni 4 mcg/mL inopesana muvanhu vane hypersensitivity inozivikanwa kune desmopress muacetate kana kune chero zvikamu zve desmopress mune acetate jekiseni 4 mcg/mL.

Desmopress mune jekiseni yeacetate inopikiswa kune varwere vane mwero kusvika kune yakaipisisa renal kukanganiswa (inotsanangurwa se creatinine clearance pazasi 50ml/min).

Desmopress mujekiseni yeacetate inopesana nevarwere vane hyponatremia kana nhoroondo ye hyponatremia.