BavivalirinZvejekiseni

250mg / Vial Simba

Chiratidzo:Bavivalirininoratidzwa kuti ishandiswe seanopokana nevarwere vari mumhirizhonga peronary coronary kupindira (PCI).

Clinical application: Iyo inoshandiswa intravenous jekiseni uye intravenous kudonha.

Zviratidzo uye Kushandiswa

1.1 Percutaneous tronluminal coronary angioplasty (Ptca)

Budivaldin ye jekiseni inoratidzwa kuti ishandiswe seanopokana nevarwere vane husina kugadzikana neanderluminal coronary angioplasty (Ptca).

1.2 Percutaneous Coronary Kupindira (PCI)

Bavalirdudin yekuzvidzwa neyekugadzirisa kweGlycopoltein iib / iiia inhibitor (GPI) sezvakanyorwa mu

Tsiva-2 kutongwa kwakaratidzwa kuti ushandiswe seanopokana nevarwere vari mumarwere ekupindirana kwekare coronary kupindira (PCI).

Bavesiradin ye jekiseni inoratidzwa kune varwere vane, kana panjodzi ye, heparin yakakundwa thromboctopenia

1.3 US E neAspirin

Budivaldin yejekiseni mune izvi zviratidzo inoitirwa kushandiswa neaspirin uye yakadzidzwa chete mune varwere vari kugamuchira aspirin aspirin.

1.4 Kuganhurwa kwekushandiswa

Iko kuchengetedzwa uye kushanda kweBilavivedin ye jekiseni hakuna kugadzwa muvarwere vane acute coronary syndromes vasiri kuzotorwa ptca kana pci.

2 Dosage uye Administration

2.1 Yakakurudzirwa DoE

Bavalirudin ye jekiseni ndeye intravenous manejimendi chete.

Budivaldin ye jekiseni yakagadzirirwa kushandiswa neaspirin (300 kusvika 325 mg zuva nezuva) uye yakadzidzwa chete mune varwere vari kugamuchira aspirin aspirin.

Kune varwere vasina kurova / hitts

Iyo Yakakurudzirwa DECE yeBilivedin ye jekiseni iri Intravenous (IV) Bolus Dosen of 0,74 MG / KWAKAKOSHESA YEMADZIMAI YEMAHARA Maminitsi mashanu mushure mekunge bolus dime ratungamirwa, akaomeserwa nguva yekuvhara (chiito) inofanira kuitwa uye imwe bolus ye 0.3 mg / kg inofanira kupihwa kana zvichidikanwa.

GPI Administration inofanira kutariswa mune chiitiko icho chero mamiriro ezvinhu akanyorwa mukutsiva-2 kiriniki kiriniki tsananguro iripo.

Kune varwere vakarova / hitts

Iyo yakakurudzirwa dosi yeBivalirdudin ye jekiseni mune varwere vane hit / hit vanopinda pci in the iv bolus ye 0,75 mg / kg. Izvi zvinofanirwa kuteverwa nekuenderera mberi kwekunyepedzera pachiyero che1,75 mg / kg / h kuti nguva yehunyanzvi.

Kuenderera mberi kurapwa kwekurapa maitiro

Budivaldin yeiyo jekiseni influsion inogona kuenderera mberi ichitevera PCI / PTCA inosvika maawa mana kusvika pakufunga kwekurapa kwekurapa chiremba.

Mune varwere vane svivi yekukwira mycardial infantion (Stemi) kuenderera mberi kweBilcedin yeiyo jekisiti influsion pachiyero che1,7.

Mushure memaawa mana, imwe yekuwedzera IV infusion yeBilivedin ye jekiseni inogona kutangwa pamwero we12 mg / kg / r (kusvika maawa kusvika maawa makumi maviri, kana zvichidikanwa.

2.2 Dosing mukukanganisika

Hapana kuderedzwa muBolus dosi kunodiwa kune chero dhigirii rekukanganisika. Iyo Infelation Dhivha yeBilivedin ye jekiseni ingangoda kuderedzwa, uye chimiro cheAnticoaGulant chakatariswa muvarwere nekukanganisa kwevaRenal. Varwere vane mwero renal kukanganisika (30 kusvika 59 ml / min) vanofanirwa kugamuchira influsion ye1,75 mg / kg / h. Kana iyo gadzirainine clearance isingasviki 30 ml / min, kuderedzwa kweiyo influsion rate kusvika 1 mg / kg / h inofanira kutariswa. Kana murwere ari paHemodilialysis, chiyero chekunyengera chinofanira kuderedzwa kusvika ku0,25 mg / kg / h.

2.3 Mirayiridzo Yekutonga

Budivaldin ye jekiseni inoitirwa intravenous bolus jekiseni uye inoenderera mberi influsion mushure mekugadzika uye dilination. Kune yega yega 250 mg vial, wedzera 5 ml yemvura isina kusvibisa yejekiseni, USP. Nyoro nyoro kusvikira zvese zvanyungudutswa. Tevere, bvisa uye rasa 5 mL kubva pamakumi mashanu eml infusion bhegi rine 5% dextrose mumvura kana 0.9% sodium chloride yejekiseni. Wobva wawedzera zviri mukati meiyo yakadzokororwa vial kune iyo influsion bhegi ine 5% dextrose mumvura kana 0.9% sodium chlentration ye5 mg / ml (semuenzaniso, 1 vial mu50 ml; 2 vials in 100 ml; 5 vials in 250 ml). Iyo dosi inofanirwa kutungamirwa inogadziriswa zvinoenderana nehuremu hwemurwere (ona tafura 1).

Kana iyo yakaderera-mwero infusike inoshandiswa mushure mekutanga infusion, bhegi repasi rezasi rinofanira kugadzirira. Kuti ugadzirire iyi yakaderera constentration, shandura iyo 250 mg vial ine 5 ml yemvura isina kusvibiswa yejekiseni, usp. Nyoro nyoro kusvikira zvese zvanyungudutswa. Tevere, bvisa uye rasa 5 mL kubva kune 500 ml infusion bhegi rine 5% dextrose mumvura kana 0.9% sodium chloride yejekiseni. Wobva wawedzera zviri mukati meiyo yakagadziridzwa vial kune bhegi rekufutisa rine 5% Dextrose mumvura kana 0.9% Sodium chloride kuti jekere yekunyora ye 0.5 mg / mg. Iyo influsion rate kuti iitwe inofanira kusarudzwa kubva kurudyi-ruoko rwemukati muTafura 1.