Igoa Vailaau: (S)-N-((3R,4S,5S)-1-(S)-2-((1R,2R)-3-((1S,2R)-1-hydroxy-1-phenylpropan-2 -yl)amino)-1-methoxy-2-methyl-3-oxopropyl)p yrrolidin-1-yl) -3-methoxy-5-methyl-1-oxoheptan-4-yl) -N,3-dimethyl-2-(S)-3-methyl-2-(methylamino)butanamido)butanamide
Molecular Weight: 717.98
Fuafuaga: C39H67N5O7
CAS: 474645-27-7
Solubility: DMSO e oʻo atu i le 20 mM

Monomethyl Auristatin E o le adolastatin-10peptide fa'atupuina fa'atasi ai ma le malosi o le antimitotic gaioiga ma le ono mafai ona fa'agaoioia antineoplastic o se vaega o le antibody-drug conjugate (ADC). Monomethyl auristatin E (MMAE) fusifusia i le tubulin, poloka le tubulin polymerization, ma faʻalavelaveina le faʻavaeina o microtubule, lea e mafua ai le faʻalavelave uma o le mitotic spindle faʻapotopotoga ma le puʻeina o sela tumo i le vaega M o le taamilosaga sela. Ina ia faʻaitiitia le oona ma faʻateleina le aoga,MMAEe tu'ufa'atasia, e ala i se feso'ota'iga peptide cleavable, i se antibody monoclonal e fa'atatau tonu i le tuma o le ma'i. O le so'otaga e mautu i le extracellular milieu ae e faigofie ona pipii e tatalaMMAEmulimuli i le fusifusia ma le faʻaogaina o le ADC e sela faʻatatau.