Igoa Vailaau:(S)-2-((2R,3R)-3-(S)-1-((3R,4S,5S)-4-((S)-N,3-dimethyl-2-((S) -3-methyl-2-(methylamino)butanamido)ae anamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoic acid

Molecular Weight:731.96
fua fa'atatau:C39H65N5O8
CAS#:141205-32-5
Solubility:DMSO e oʻo atu i le 20 mM

Gaioiga Fa'aola
Monomethyl auristatin F (MMAF) poʻo le desmethyl-auristatin F o se anti-tubulin agent e faʻalavelaveina le vaeluaga o sela e ala i le polokaina o le polymerization o tubulin. O se mea fouauristatin fa'atupufaatasi ai ma se phenylalanine C-terminal ua molia e faʻaitiitia ai lona gaioiga cytotoxic pe a faʻatusatusa i lona tulaga e leʻi totogiina, monomethyl auristatin E (MMAE). E le gata i lea, o le N-terminal amino group e naʻotasimethyl substituent nai lo le lua pei o totonuauristatin Flava ia.