Dzina la Chemical: (S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2 -yl)amino) -1-methoxy-2-methyl-3-oxopropyl)p yrrolidin-1-yl) -3-methoxy-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide
Katundu Wolemera: 717.98
Chithunzi cha C39H67N5O7
CAS: 474645-27-7
Kusungunuka: DMSO mpaka 20 mm

Monomethyl Auristatin E ndidolastatin-10chochokera ku peptide chokhala ndi zochita zamphamvu za antimitotic komanso zomwe zingachitike ngati gawo la antibody-drug conjugate (ADC). Monomethyl auristatin E (MMAE) kumangiriza ku tubulin, kutsekereza tubulin polymerization, ndikulepheretsa mapangidwe a microtubule, zomwe zimabweretsa kusokonezeka kwa msonkhano wa mitotic spindle ndi kumangidwa kwa maselo a chotupa mu gawo la M la maselo. Kuchepetsa kawopsedwe ndikuwonjezera mphamvu,MMAEimalumikizidwa, kudzera pa peptide linker yoduka, kupita ku anti-monoclonal yomwe imayang'ana chotupa cha wodwala. Cholumikiziracho chimakhala chokhazikika mumtundu wa extracellular koma chimamangika mosavuta kuti chimasulidweMMAEkutsatira kumanga ndi kulowetsa mkati mwa ADC ndi ma cell omwe akutsata.