Ingoa matū: (S) -n - ((3r, 4s 4s) -1 - ((1r, 2R) -2 - (((((HAYDROXY-1-PHEYLPPARPAN-2 -yl) amino) -1 -1-methoxy-2-methyl-3-oxopropyl) p YRrolidin-1-YL) -3-athoxy-5-othyl-1-oxeheptan-4-yl) -n, 3-dimethyl-2 - ((methylano) butnanamido) beantamido) butnanamide
Taumaha Momotu: 717.98
Puka: C39H67N5O7
Cas: 474645-27-7
Whakatika: DMSO tae noa ki te 20 mm

Monomethyl auristatin e teDolastatin-10Ko nga mahi peptide me te mahi antimotitito tino me nga mahi antineoplashitic hei waahanga o te konutai-tarukino (ADC). Monomethyl auristatin e (Mmae) Ka herea ki te ruaulin, ka poraka i te hanganga o MicroTubule, ka pa ki te aukati i te huihuinga o te MITOT Spindle me te hopu i nga pūtau puku i te Putanga Pūmanawa. Ki te whakaiti i te paitini me te whakanui i te whaihua,Mmaekua whakauruhia, ma te kaihoroi pepken maamaa, ki te antibody monoclonal e tino aro ana ki te puku o te manawanui. Ko te kaihoroi he pumau i roto i te milieu taapiri engari ka piri ke ki te tukuMmaeWhai muri i te here me te whakaputa i te ADC e nga pūtau whaainga.