Ingoa matū: (S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2 -yl)amino)-1-methoxy-2-methyl-3-oxopropyl)p yrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide
Taumaha rāpoi: 717.98
Tātai: C39H67N5O7
CAS: 474645-27-7
Wairewa: DMSO ki te 20 mM

Ko te Monomethyl Auristatin E he adolastatin-10pärönaki peptide me te kaha antimitotic mahi me te mahi antineoplastic pea hei waahanga o te antibody-drug conjugate (ADC). Monomethyl auristatin E (MMAE) ka herea ki te tubulin, ka aukati i te polymerization tubulin, ka aukati i te hanganga o te microtubule, ka hua mai i te pakaru o te whakahiato miro miro me te hopu i nga pūtau puku i te wahanga M o te huringa pūtau. Hei whakaiti i te paitini me te whakanui i te whaihua,MMAEka honoa, ma te hononga peptide ka taea, ki tetahi antibody monoclonal e aro ana ki te puku o te manawanui. Kei te noho pumau te hono ki roto i te taiao extracellular engari ka ngawari ki te weheMMAEwhai muri i te herenga me te whakaurunga o te ADC e nga pūtau i whäia.