Aha kemịkalụ: (S)-N-((3R,4S,5S)-1-((S)-2-(1R,2R)-3-((1S,2R)-1-hydroxy-1-phenylpropan-2 -yl) amino)-1-methoxy-2-methyl-3-oxopropyl) p yrrolidin-1-yl) -3-methoxy-5-methyl-1-oxoheptan-4-yl) -N,3-dimethyl-2- ((S) -3-methyl-2- (methylamino) butanamido) butanamide
Arọ molekụla: 717.98
Usoro: C39H67N5O7
Nọmba: 474645-27-7
Solubility: DMSO ruo 20 mM

Monomethyl Auristatin E bụ adolastatin-10ihe nrụpụta peptide nwere ọrụ antimitotic siri ike yana ọrụ antineoplastic nwere ike dị ka akụkụ nke conjugate ọgwụ mgbochi (ADC). Monomethyl auristatin EMMAE) na-ejikọta ya na tubulin, na-egbochi tubulin polymerization, ma na-egbochi nhazi microtubule, nke na-ebute ma nkwụsị nke mgbakọ mitotic spindle na njide nke mkpụrụ ndụ tumo na usoro M nke usoro cell. Iji wedata nsi ma bulie arụmọrụ ya,MMAEA na-ejikọta ya, site na peptide linker, na mgbochi monoclonal nke na-elekwasị anya kpọmkwem etuto onye ọrịa. Ihe njikọ ahụ kwụsiri ike na milieu extracellular mana ọ jikọtara ya ngwa ngwa ka ọ hapụ yaMMAEna-esote njide na ntinye nke ADC site na sel ebumnuche.