Lub npe tshuaj: (S)-N-(((3R,4S,5S)-1-(S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2 -yl)amino)-1-methoxy-2-methyl-3-oxopropyl) p yrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-(((S)-3-methyl-2-(methylamino)butanamido)butanamide
Molecular Luj: 717.98
Cov roj formula: C39H67N5O7
CAS: 474645-27-7 Nr
Solubility: DMSO mus txog 20 mM

Monomethyl Auristatin E yog ibdolastatin-10peptide derivative nrog muaj zog antimitotic kev ua si thiab muaj peev xwm ua haujlwm antineoplastic ua ib feem ntawm cov tshuaj tiv thaiv kab mob sib xyaw (ADC). Monomethyl auristatin E (nrog rau cov khoom lag luam)MMAE) khi rau tubulin, blocks tubulin polymerization, thiab inhibits microtubule tsim, uas ua rau ob qho tib si cuam tshuam ntawm mitotic spindle sib dhos thiab ntes cov qog hlwb hauv M theem ntawm lub voj voog ntawm tes. Txhawm rau txo toxicity thiab ua kom muaj txiaj ntsig zoo,MMAEyog conjugated, ntawm ib tug cleavable peptide linker, mus rau ib tug monoclonal antibody uas tshwj xeeb yog tsom rau tus neeg mob cov qog. Lub linker yog ruaj khov nyob rau hauv lub extracellular milieu tab sis yog nkag cleaved kom tso tawmMMAEtom qab khi thiab internalization ntawm ADC los ntawm lub hom phiaj hlwb.