Tshuaj Npe: (S) -n - ((3r, 4s, 5s, 5s)-1 - ((1s, 2r)-1-hydroxy-1-phenylopan-1 -yl) amino) -1-methoxy-2-methyl-3-oxopropyl) p Yrrolidin-1-YL) -3-Methyl-5-OxoHephatan-4-YL) -0, 3-Methyl-2- (Methylas) Buthanamido) Butanamide
Molecular hnyav: 717.98
Cov Qauv: C39H67N5O7
CAS: 474645-27-7
Solubility: dmo txog 20 hli

Monomethyl autistatin e yog adolastatin-10Peptide derivative nrog kev siv tshuaj tiv thaiv kab mob antimitotic thiab muaj peev xwm antineoplastic kev ua si ua ib feem ntawm cov tshuaj tiv thaiv tshuaj tiv thaiv yeeb tshuaj (ADC). Monomethyl auristatin e (Tus nai) khi rau tubulin, blocks tubulin polymerization, thiab inhibits microtict conndle sib dhos thiab ntes cov qog nqaij hauv m kis ntawm lub voj voog ntawm tes. Kom txo qis toxicity thiab ua kom zoo tshaj plaws ua tau zoo,Tus naiyog conjugated, ntawm ib tug cleavable peptide Linker, rau ib monoclonal antibody uas tshwj xeeb cov tub rog tus neeg mob cov qog. Cov ntawv txuas yog ruaj khov nyob rau hauv cov extracellular milieu tab sis yog yooj yim cleaved tsoTus naiTom qab khi thiab kev sab hauv ntawm ADC los ntawm lub hom phiaj.