Inoa Kimia: (S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2 -yl)amino)-1-methoxy-2-methyl-3-oxopropyl)p yrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-(S)-3-methyl-2-(methylamino)butanamido)butanamide
Kaumaha Molekala: 717.98
Kumu: C39H67N5O7
CAS: 474645-27-7
Solubility: DMSO a hiki i 20 mM

ʻO ka Monomethyl Auristatin E kahidolastatin-10peptide derivative me ka hana antimitotic ikaika a me ka hana antineoplastic ma ke ʻano he ʻāpana o ka antibody-drug conjugate (ADC). Monomethyl auristatin E (MMAE) hoʻopaʻa i ka tubulin, ālai i ka polymerization tubulin, a keʻakeʻa i ka hoʻokumu ʻana o ka microtubule, e hopena i ka hoʻopau ʻana i ka hui ʻana o ka mitotic spindle a me ka hopu ʻana i nā cell tumor i ka M phase o ka pōʻai cell. E hōʻemi i ka ʻawaʻawa a hoʻonui i ka pono,MMAEHoʻohui ʻia, ma o kahi mea hoʻopili peptide hiki ke hoʻokaʻawale ʻia, i kahi antibody monoclonal e kuhikuhi pono ana i ka ʻōpū o ka mea maʻi. Paʻa ka loulou i loko o ka extracellular milieu akā hiki ke hoʻopaʻa ʻia e hoʻokuʻuMMAEma hope o ka hoʻopaʻa ʻana a me ka hoʻokomo ʻia ʻana o ka ADC e nā cell target.