Sunan Sinadari: (S)-N-((3R,4S,5S)-1-((S)-2-(1R,2R)-3-((1S,2R)-1-hydroxy-1-phenylpropan-2 -yl)amino)-1-methoxy-2-methyl-3-oxopropyl) p yrrolidin-1-yl) -3-methoxy-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2- (methylamino) butanamido) butanamide
Nauyin Kwayoyin: 717.98
Saukewa: C39H67N5O7
Saukewa: 474645-27-7
Solubility: DMSO har zuwa 20 mM

Monomethyl Auristatin Edolastatin-10Abubuwan da aka samu na peptide tare da aikin antimitotic mai ƙarfi da yuwuwar ayyukan antineoplastic a matsayin wani ɓangare na haɗin gwiwar maganin rigakafi (ADC). Monomethyl auristatin EMMAE) yana ɗaure da tubulin, yana toshe tubulin polymerization, kuma yana hana haɓakar microtubule, wanda ke haifar da rushewar taro na mitotic spindle da kama ƙwayoyin tumor a cikin M lokaci na sake zagayowar tantanin halitta. Don rage yawan guba da haɓaka inganci,MMAEAn haɗa shi, ta hanyar haɗin peptide mai iya cleavable, zuwa wani antibody na monoclonal wanda ke kai hari musamman game da ciwon mara lafiya. Mai haɗin yanar gizon yana da ƙarfi a cikin milieu na extracellular amma yana shirye don sakiMMAEbin ɗauri da ciki na ADC ta sel masu manufa.