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Monomethylauristatin F (MMAF)
Ainm Ceimigeach: (S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-dimethyl-2-((S)) -3-methyl-2-(methylamino)butanamido)ach anamido)-3-methoxy-5-methylheptanoyl) pyrrolidin-2-il)-3-methoxy-2-methylpropanamido)-3-phenylpropanoic Cuideam Molecular searbhagach: 731.96 Formula: C39H65N5O8 CAS #: 141205-32-5 Solubility: DMSO suas gu 20 mM Gnìomhachd Bith-eòlasach Tha Monomethyl auristatin F (MMAF) no desmethyl-auristatin F na àidseant an-aghaidh tubulin a chuireas casg air roinneadh cealla le bhith a’ bacadh roinneadh cealla de tubulin. Tha e na ... -
Monomethyl Auristatin E (MMAE)
Ainm Ceimigeach: (S) -N-((3R,4S,5S)-1-(S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2) -yl) amino)-1-methoxy-2-methyl-3-oxopropyl)p yrrolidin-1-il)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-(S)-3-methyl-2-(methylamino)butanamido)butanamide Cuideam Molecular: 717.98 Formula: C39H67N5O7 CAS: 474645-27-7 Solubility: DMSO suas gu 20 mM Tha Monomethyl Auristatin E na derivative peptide dolastatin-10 le gnìomhachd làidir antimitotic agus gnìomhachd antineoplastic a dh’fhaodadh a bhith ann mar phàirt de antibody.