Ainm Ceimigeach:(S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-dimethyl-2-((S)) -3-methyl-2-(methylamino)butanamido)ach anamido)-3-methoxy-5-methylheptanoyl) pyrrolidin-2-il)-3-methoxy-2-methylpropanamido)-3-phenylpropanoic searbhag
Cuideam moileciuil:731.96
Foirmle:C39H65N5O8
CAS #:141205-32-5
Solubility:DMSO suas gu 20 mM
Gnìomh Bith-eòlais
Tha monomethyl auristatin F (MMAF) no desmethyl-auristatin F na àidseant an-aghaidh tubulin a chuireas casg air roinneadh cealla le bhith a’ bacadh polymerization tubulin. Is e rud ùr a th’ annauristatin derivativele phenylalanine C-terminal fo chasaid a lughdaicheas a ghnìomhachd cytotoxic an taca ris a’ bhuidheann neo-phàighte aige, monomethyl auristatin E (MMAE). A bharrachd air an sin, chan eil ach aig a’ bhuidheann amino N-terminalaonneach-ionaid methyl an àite dhà mar a tha eauristatin Ffein.