Umkhiqizo: I-Linaclotide
Igama elifanayo: I-Linaclotide Acetate
Inombolo ye-CAS: 851199-59-2
I-Molecular Formula: C59H79N15O21S6
Isisindo se-molecule: 1526.8
Ukubukeka: Impushana emhlophe
Ubumsulwa: >98%
Ukulandelana: NH2-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH
I-Linaclotide iyi-synthetic, i-amino acid peptide eyishumi nane kanye ne-agonist yohlobo lwe-guanylate cyclase yamathumbu C (GC-C), ehlobene ngokuhlelekile nomndeni we-guanylin peptide, ene-secretagogue, i-analgesic kanye nemisebenzi yokulambisa. Lapho isetshenziswa ngomlomo, i-linaclotide ibopha futhi ivule ama-GC-C receptors asendaweni ekhanyayo ye-epithelium yamathumbu. Lokhu kwandisa ukugcwala kwe-intracellular cyclic guanosine monophosphate (cGMP), etholakala ku-guanosine triphosphate (GTP). I-cGMP yenza kusebenze isilawuli se-cystic fibrosis transmembrane conductance (CFTR) futhi ikhuthaze ukukhishwa kwe-chloride ne-bicarbonate kulume lwamathumbu. Lokhu kukhuthaza ukuphuma kwe-sodium ku-lumen futhi kubangele ukwanda koketshezi lwamathumbu emathunjini. Lokhu ekugcineni kusheshisa ukuhamba kwe-GI kokuqukethwe kwamathumbu, kuthuthukisa ukuhamba kwamathumbu futhi kukhulule ukuqunjelwa. Ukwenyuka kwamazinga e-cGMP e-extracellular kungase futhi kube nomphumela we-antinociceptive, ngokusebenzisa indlela engakacaciswanga ngokugcwele, engabandakanya ukuguqulwa kwama-nociceptors atholakala ku-colonic afferent pain fibers. I-Linaclotide imuncwa kancane epheshaneni le-GI.
Iphrofayela Yenkampani:
Igama lenkampani: Shenzhen JYMed Technology Co., Ltd.
Unyaka owasungulwa: 2009
Inhlokodolobha: 89.5 Million RMB
Umkhiqizo oyinhloko: I-Oxytocin Acetate,Vasopressin Acetate,Desmopressin Acetate,Terlipressin acetate,Caspofungin acetate,Micafungin sodium,Eptifibatide acetate,Bivalirudin TFA,Deslorelin Acetate,Glucagon Acetate,Histrelin Acetate,LietateglueAcetate ,Degarelix Acetate,Buserelin Acetate,Cetrorelix Acetate,Goserelin
I-Acetate, i-Argireline Acetate, i-Metrixyl Acetate, i-Snap-8,…..
Silwela ukuqhubeka nokuqamba izinto ezintsha kubuchwepheshe obusha be-peptide synthesis kanye nokwenza ngcono inqubo, futhi ithimba lethu lezobuchwepheshe linolwazi olungaphezu kweminyaka eyishumi ku-peptide synthesis.I-JYM ithumele ngempumelelo okuningi.
ye-ANDA peptide APIs kanye nemikhiqizo eyenziwe nge-CFDA futhi inamalungelo obunikazi angaphezu kwamashumi amane agunyaziwe.
Imboni yethu ye-peptide itholakala eNanjing, esifundazweni saseJiangsu futhi isimise indawo engamamitha-skwele angama-30,000 ngokuhambisana nomhlahlandlela we-cGMP. Indawo yokukhiqiza isihloliwe futhi yahlolwa yiwo womabili amaklayenti asekhaya nawamazwe ngamazwe.
Ngekhwalithi yayo enhle kakhulu, intengo encintisana kakhulu nokusekelwa okuqinile kwezobuchwepheshe, i-JYM ayigcinanga ngokuthola ukuqashelwa kwemikhiqizo yayo ezinhlanganweni zoCwaningo kanye nezimboni Zemithi, kodwa futhi ibe omunye wabahlinzeki abathembekile bama-peptide e-China,. I-JYM inikezelwe ukuba ngomunye wabahlinzeki be-peptide abahamba phambili emhlabeni maduze nje.