Umthandi

Semullutideiyi-peptucagon-efana ne-peptide-1 (glp-1) i-abonist ye-receptor esetshenziselwa ukulawula amazinga we-glucose egazi ezigulini ngesifo sikashukela sohlobo 2. I-GLP-1 iyi-hormone endobeni etholwe amaseli we-L-ama-amathumbu amancane ngemuva kokudla, ukudlala izindima eziningi zomzimba. I-Semaglutide lilingisa izenzo zomzimba ze-glp-1 futhi zilawula ushukela wegazi nezisindo ngezindlela ezintathu eziphambili:

1. Ukukhuthaza Ukukhishwa Kwe-Insulin: I-GLP-1 ivuselela imfihlo ye-insulin kusuka kuma-pancreatic β-cell lapho amazinga kashukela egazi aphakanyiswa, asiza ukwehlisa ushukela wegazi. I-Semaglutide ithuthukisa le nqubo ngokwenza i-puleptor ye-GLP-1, ikakhulukazi idlala indima ebalulekile ekuphatheni i-Hyprandial Hyperglycemia. Le ndlela inika amandla i-semaglutide ukunciphisa ngempumelelo ama-glucose spikes we-post
2. Ukuvinjwa kwe-glucagon secretionKu: Glucagon yi-hormone etholwe yi-pancreatic α-cell ekhuthaza ukukhishwa kwe-glucose kusuka esibindini lapho amazinga kashukela egazi aphansi. Kodwa-ke, ezigulini ezinesifo sikashukela sohlobo 2, imfihlo ye-glucagon imvamisa yanda ngokungafanele, okuholela emazingeni aphezulu we-glucose egazi. ISemaglutide ivimbela imfihlo ngokweqile ye-glucagon ngokwenza i-gep-1 receptor, isiza kakhulu ukwehlisa amazinga kashukela wegazi.
3. Ukuncipha kwesisulu se-gastric: Semarlutide futhi ibambezela izinga lokuthululwa kwesisu, okusho ukuthi ukudlula kokudla kusuka esiswini kuya esithunzini esincane kubambezelekile, okuholela ekukhuphukeni kancane kancane emazingeni aphansi we-glucose. Lo mphumela awusizi kuphela ukulawula ushukela wegazi ongemuva kodwa futhi wandisa umuzwa wokugcwala, ukunciphisa ukudla okuningana nokusiza ekuphathweni kwesisindo.

Ngaphandle kwemiphumela yawo emthethweni we-glucose wegazi, i-semaglutide ikhombisile izinzuzo ezibalulekile zokunciphisa umzimba, okwenza kube ngumuntu ozongenela ukhetho lokukhululwa kokukhuluphala. Ukuncishiswa kwesisindo akusizi kuphela kwiziguli zesifo sikashukela kepha nakwabanye abangeyena ushukela abanokukhuluphala.

Indlela ehlukile kanye nokusebenza kwemitholampilo kweSemaglutide kwenza kube yisidakamizwa esisemqoka ekuphathweni kwezifo zesifo sikashukela. Ngaphezu kwalokho, njengoba ucwaningo luqhubeka, ukusetshenziswa okungenzeka kwe-semarlutide ekuvikelweni kwenhliziyo nokuphathwa kokukhuluphala kuthola ukunakwa. Kodwa-ke, eminye imiphumela emibi, efana nokungakhululeki kwesisu kanye ne-nausea, kungenzeka ngesikhathi sokusebenzisa i-semarlutide, ngakho-ke kufanele isetshenziswe ngaphansi kokuqashwa kwezokwelashwa.

Liraglutideyi-peptuagon-like peptide-1 (zpp-1) i-abonist ye-receptor esetshenziswa ngokuyinhloko ekwelapheni isifo sikashukela sohlobo 2 nokukhuluphala. I-GLP-1 i-hormone etholwe amaseli we-L-ama-L-amathumbu amancane ngemuva kokudla, futhi idlala izindima eziningi ekulawuleni ushukela wegazi. I-LiragLutide Memics isenzo se-GLP-1, inika imiphumela eminingana ebalulekile yomzimba:

1. Ukukhuthaza Ukukhishwa Kwe-Insulin: Lapho amazinga kashukela egazi avuka, i-GLP-1 ivuselela imfihlo ye-insulin kusuka kuma-pancreatic β-cell, isiza ukwehlisa amazinga e-glucose egazi. I-LiragLutide ithuthukisa le nqubo ngokwenza i-CHP-1 Receptor, ikakhulukazi ngcono i-glucose control ngesikhathi se-hyperglycescemia esedlule. Lokhu kwenza i-liraglutide esetshenziswe kabanzi ekuphatheni amazinga we-post-metha glucose amazinga ezigulini ezinesifo sikashukela sohlobo 2.
2. Ukuvinjwa kwe-glucagon secretion: I-Glucagon i-hormone etholwa yi-pancreatic α-cell evame ukukhulisa ukukhishwa kwe-glucose esibindini lapho amazinga kashukela egazi aphansi. Kodwa-ke, ezigulini ezinesifo sikashukela sohlobo 2, imfihlo ye-glucagon ivame ukuphakama ngokungafanele, okuholela emazingeni aphezulu we-glucose. ILiragLutide isiza ukulawula ushukela wegazi ngokuvimbela ukutholakala kwe-glucagon, kunciphisa ukuguquguquka kweglucose yegazi kuziguli ezinesifo sikashukela.
3. Ukubambezela ukukhishwa kwesisu: ILiraglutide ibuye ibambezele isisulu, okusho ukuthi ukunyakaza kokudla kusuka esiswini kuya emathunjini amancane kuyabambezeleka, okuholela ekukhuphukeni kwamagquma aphansi wegazi. Lo mphumela hhayi nje kuphela ingculazi egcekeni leglucoolose yegazi kodwa futhi kwandisa umuzwa wokugcwala, ukunciphisa ukudla nokudla nokusiza iziguli ukuphatha isisindo sazo.
4. Ukuphathwa kwesisindo: Ngaphezu kwemiphumela yako ekuphathweni kwe-glucose yegazi, iLiraglutide ikhombisile izinzuzo ezibalulekile zokunciphisa umzimba. Lokhu kungenxa yemiphumela yayo ekunciphiseni i-gastric ukuthulula kanye nokwanda kwengqondo, okuholela ekunciphiseni imali yokuphuza nokunciphisa umzimba. Ngenxa yokusebenza kwayo ekunciphiseni isisindo, i-liraglutide nayo isetshenziswa ekwelashweni kokukhuluphala ngokweqile, ikakhulukazi ezigulini zikashukela ngokukhuluphala.
5. Ukuvikelwa kwenhliziyo: Ucwaningo lwakamuva lukhombisile ukuthi iLiraglutide futhi inemiphumela yokuvikela yenhliziyo, ukunciphisa ubungozi bezehlakalo zenhliziyo. Lokhu kuholele ekusetshenzisweni kwayo okusakazekile okubanzi ezigulini ezinesifo sikashukela kanye nesifo senhliziyo.

Ngamafuphi, iLiraglutide ilawula ushukela wegazi futhi isisindo ngokusebenzisa izindlela eziningi, ukudlala indima ebaluleke kakhulu ekuphathweni kwesifo sikashukela nokubonisa amandla ekwelashweni kokukhuluphala kanye nokuvikelwa kwenhliziyo. Kodwa-ke, eminye imiphumela emibi, efana nesicanucanu, ukugabha, kanye ne-hypoglycemia, kungenzeka ngesikhathi sokusebenzisa iLiraglutide, ngakho-ke kufanele isetshenziswe ngaphansi kokuqashwa kwezokwelashwa ukuze kuqinisekiswe ukuphepha nokusebenza ngempumelelo.

TirtzepathideIngabe umuthi wokusebenza we-peptide wesenzo esisha esenziwe ngokuqondile usebenze ngasikhathi sinye usebenze i-glucagon-efana ne-peptide-1 (glp-1) ama-anulinotrotror-ancike insulinotropic polypEptide (GIP) receptors. Le agonism e-rup receptor inika ama-tirezepatide ahlukile emtholampilo ngokulawula uhlobo 2 sikashukela nokuphatha isisindo.

1. I-GLP-1 reakeptor agOnism: I-GLP-1 iyi-hormone endobeni etholwe amaseli we-L-ama-amathumbu ngemuva kokudla, ukukhuthaza ukubonwa kwe-insulin, kuvimbela ukukhishwa kwe-glucagon, futhi kubambezele ukuthungwa kwesisu. I-TirzePatide ithuthukisa le miphumela ngokwenza i-CLP-1 Receptors, isiza ukwehlisa ngempumelelo amazinga we-glucose wegazi, ikakhulukazi ekuphathweni kwe-glucose postprandial. Ngokwengeziwe, ukusebenza kwe-perp-1 receptor kwandisa umuzwa, ukunciphisa ukudla nokudla nokusiza ekunciphiseni isisindo.
2. I-GIP Receptor Abonism: I-GIP kungenye i-hormone ye-incretin etholwe amaseli we-K-emathunjini, athuthukise imfihlo ye-insulin kanye nokulawula imetabolism enamafutha. I-TirzePatide ithuthukisa imfihlo ye-insulin ngokwenza kusebenze ama-receptors we-GIP futhi inemiphumela emihle kuma-fat tessus tessus. Le ndlela yesenzo esimbaxambili inika i-Tirezeptide inzuzo enkulu ekwenzeni ngcono ukuzwela kwe-insulin, ukwehlisa amazinga kashukela wegazi, nokuphatha isisindo.
3. Ukubambezelwa kwesisu: UTirzePtide futhi ubambezela ukuthulula i-gastric, okusho ukuthi ukunyakaza kokudla okuvela esiswini kuya esisukwini esincane kuncibilike, kuholele ekuphakameni kancane kancane emazingeni aphansi we-glucose. Lo mphumela awusizi nje kuphela ukulawula ushukela wegazi kodwa futhi kwandisa umuzwa wokugcwala, ukunciphisa nokunciphisa ukudla.
4. Ukuphathwa kwesisindo: Ngenxa yokuvuselelwa kwayo okubili kwama-glp-1 ne-GIP receptors, i-tirzepatide ikhombisile imiphumela ebalulekile ekuphathweni kwesisindo. Ucwaningo lweMitholampilo lukhombisile ukuthi i-Tirezepatide inganciphisa kakhulu isisindo somzimba, esizuzisa kakhulu iziguli zesifo sikashukela soshukela ezidinga ukulawula isisindo sazo.

Indlela esetshenziswayo yeTirzePATIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDE inikezela inketho entsha yokwelapha ekuphatheni isifo sikashukela 2, ukulawula kahle ushukela wegazi ngenkathi usiza iziguli ukufezekisa isisindo, ngaleyo ndlela kuthuthukiswe impilo yonke. Naphezu kwemiphumela yayo ebalulekile yemitholampilo, eminye imiphumela emibi, efana nokungakhululeki kwesisu, kungenzeka ngesikhathi sokusetshenziswa kwe-tirezepatide, ngakho-ke kufanele isetshenziswe ngaphansi kokuqashwa kwezokwelashwa.

OxytocinI-hormone eyenzeka ngokwemvelo ye-peptide yemvelo eyenziwe nge-hypothalamus futhi igcinwe futhi ikhishwe yindlala yangemuva le-pituitary. Ibamba iqhaza elibalulekile ohlelweni lokuzala lwabesifazane, ikakhulukazi ngesikhathi sokusebenza kanye nesikhathi se-postpartum. Umsebenzi oyinhloko we-Oxetocin ukukhuthaza ukuncishiswa kwemisipha ye-Uterine ngokubopha ama-oxytocin receptors kumaseli wemisipha ebushelelezi esibeletho. Lesi senzo sibalulekile ekuqaleni futhi silondoloze inqubo yabasebenzi.

Ngesikhathi sokubeletha, njengoba ingane ihamba nge-canal yokuzalwa, ukukhishwa kwe-oxytocin kuyakhuphuka, okuholela ezinkomeni zesibeletho eziqinile nezinesigqi ezisiza ukuletha ingane. Uma ukuthuthuka kwemvelo kwabasebenzi kuhamba kancane noma kukhungathekile, i-oksinsocin eyenziwe ngobuningi ingahle iphathwe ngendlela yomhlinzeki wezokunakekelwa kwempilo ukuze athuthukise izinkomba ze-uterine futhi asheshise inqubo yezabasebenzi. Le nqubo yaziwa njengokungeniswa kwabasebenzi.

Ngaphezu kokufukula abasebenzi, i-oxetocin isetshenziswa kabanzi ukulawula i-postpartum hemorrhage, inselelo evamile futhi engaba yingozi ngemuva kokuzalwa kwengane. I-PostPartum Hemorrhage imvamisa yenzeka lapho isibeletho sehluleka ukukhokhela ngempumelelo ngemuva kokulethwa. Ngokuthuthukisa izivumelwano zesibeletho, i-oxytocin kusiza ukunciphisa ukulahleka kwegazi, ngaleyo ndlela kwehlise ubungozi empilweni kamama obangelwa ukopha ngokweqile.

Ngaphezu kwalokho, i-Oxetocin idlala indima enkulu ekunceliseni ibele. Lapho usana luyancipha engosini kamama, i-oxetocin ikhishwa, ibangela izindwani zobisi ukuze zithole inkontileka futhi zicindezele ubisi ngokusebenzisa ama-ducts, kusiza ukukhishwa kobisi. Le nqubo ibalulekile ekunceliseni ibele okuphumelelayo, futhi kwesinye isikhathi i-oxytocin kwesinye isikhathi isetshenziselwa ukusiza omama abahlangabezana nobunzima ngesikhathi se-lactation.

Sekukonke, i-Oxetocin isidakamizwa esisemqoka kuma-obstertyrics, ngezicelo ezisabalele ekusebenzeni kwabasebenzi, ukulawula i-postpartum hemorrhage, futhi isekela ukuncelisa ibele. Ngenkathi i-Oxetocin ngokuvamile iphephile ukuyisebenzisa, ukuphathwa kwayo kufanele ngaso sonke isikhathi kuqondiswe ochwepheshe bezokwelapha ukuqinisekisa imiphumela yokwelapha efanelekile futhi inciphise imiphumela emibi.

CarbetocinIngabe i-analog ye-oxytocin eyenziwe ngobunye esetshenziselwa ukuvikela i-postpartum hemorrhage, ikakhulukazi alandele izingxenye zeCesarean. I-PostPartum Hemorrhage iyizinkinga ezinkulu ezingenzeka ngemuva kokuzalwa kwengane, imvamisa ngenxa ye-uterine atony, lapho isibeletho sehluleka ukukhokhela ngempumelelo. I-Carbetocin isebenza ngokubopha ama-oxytocin receptors ebusweni bezinga le-Uterine ebushelelezi, isebenze ama-receptors, kanye nokufaka izivumelwano zesibeletho, ngaleyo ndlela kusize ukunciphisa ukulahleka kwegazi kwegazi ngemuva.

Uma kuqhathaniswa ne-Oxytocin yemvelo, i-carbetocin inempilo ende, okusho ukuthi ihlala isebenza emzimbeni isikhathi esengeziwe. Lo msebenzi oqhubeka isikhathi eside uvumela i-carbetocin ukuthi ihlinzeke ngezivumelwano zesibeletho eziqhubekayo, okwenza kube yimpumelelo ekuvikeleni i-postpartum hemorrhage. Ngokwengeziwe, i-carbetocin ayidingi ukumiliselwa okuqhubekayo njenge-oxytocin kepha ingahanjiswa njengomjovo owodwa, ukwenza lula inqubo yezokwelapha kanye nokunciphisa ukufunwa kwezinsiza zezokwelapha.

Ucwaningo lweMitholampilo lukhombisile ukuthi i-carbetocin isebenza kakhulu ekuvikeleni ukopha okulandela izingxenye ze-cesarean, kunciphisa kakhulu isidingo semithi eyengeziwe ye-Uletotonic. I-World Health Organisation (WHO) ifake i-carbetocin njengokwelashwa okujwayelekile kokuvimbela i-postpartum hemorrhage, ikakhulukazi ezilungiselelweni ezikhawulelwe ezinsizakusebenza lapho izinzuzo zabaphathi bedosi olulodwa zizuzisa ikakhulukazi.

Kubalulekile ukuqaphela ukuthi ngenkathi i-carbetocin inikeza izinzuzo ezibalulekile ekuvikeleni i-postpartum hemorrhage, kungenzeka ingalungele zonke izimo. Ezimweni ezithile, njenge-sitere ngokweqile, okunamathiselwe okungajwayelekile kwe-placental, noma ukunqanyulwa, ezinye izindlela zokwelashwa zingase zifaneleke ngokwengeziwe. Ngakho-ke, ukusetshenziswa kwe-carbetocin kufanele kunqunywe ngabachwepheshe bezempilo abanolwazi ngokususelwa ezimweni ezithile.

Ngamafuphi, i-carbetocin, njenge-oxytocin analog ethatha isikhathi eside, idlala indima ebalulekile ekuvikeleni i-postpartum hemorrhage kulandela izingxenye zakwa-cesarean kanye nokulethwa kwangasese. Ngokukhuthaza izivumelwano zesibeletho, kunciphisa ngempumelelo ingozi yokopha kwe-postpartum, ukuhlinzeka ngokuvikelwa okubalulekile kokuzalwa kwengane ephephile.

I-terligressinIngabe i-analog yokwenziwa ye-antidiefetic hormone esetshenziselwa ukwelapha ukuphazamiseka kokopha okubangelwa yi-cirrhosis yesibindi, efana ne-esophageal variceal yogazi ne-heparenal syndrome ne-heparenal syndrome kanye ne-heparenal syndrome. I-Esophageal Variceal Bloeding iyinkinga ejwayelekile futhi enzima ezigulini ezinama-cirrhosis wesibindi, ngenkathi i-heparenal syndrome uhlobo lokuhluleka kwezinso okubangelwa ukungasebenzi kahle kwesibindi.

I-Terligressin isebenza ngokulingisa isenzo se-hormone ye-antidiuretic (Vasopressin), okwenza ukuthi inqwaba yemithambo yegazi ye-visceral, ikakhulukazi epheshana esiswini, ngaleyo ndlela kunciphisa ukugeleza kwegazi kulezi zitho. Le vasoConstriction isiza ukwehlisa ingcindezi ye-vein ye-portal, ukunciphisa ubungozi bokuphuma okuqabulayo. Ngokungafani ne-Vasopressin yendabuko, i-terligressin inesikhathi eside sesenzo kanye nemiphumela emibi embalwa, okwenza ukuthi isetshenziswe kabanzi ekusebenzeni kwemitholampilo.

Ngaphezu kokusetshenziswa kwayo ukopha okukhulu, i-terlipmelin idlala indima ebalulekile ekwelapheni i-heparenal syndrome. I-Hepaternal syndrome imvamisa yenzeka ezigabeni ezithuthukile zesifo sowesibindi sesibindi, ezibonakala ngokuncipha okusheshayo emsebenzini wezinso, ngesilinganiso esiphansi kakhulu sokusinda. I-Terligressin ingathuthukisa ukugeleza kwegazi le-renal, ukubuyisa umsebenzi wezinso kuncipha, futhi kuthuthukise kakhulu imiphumela yeziguli.

Kubalulekile ukuqaphela ukuthi ngenkathi i-Terligring isebenza kakhulu ekwelapheni lezi zimo ezibucayi, ukusetshenziswa kwayo kuthwala ubungozi obuthile, njengemiphumela emibi yenhliziyo. Ngakho-ke, i-terligressin ngokuvamile ilawulwa endaweni ehleli esibhedlela ngaphansi kokubhekwa kakhulu ngabasebenzi bezokunakekelwa kwempilo ukuqinisekisa ukuphepha nokusebenza ngempumelelo kokwelashwa.

Ngamafuphi, i-terligressin, njengesidakamizwa se-peptide, idlala indima engenakuphikwa ekwelapheni ukopha okunamandla kanye ne-heparenal syndrome ebangelwa yi-cirrhosis yesibindi. Akulawule ngempumelelo ukopha kuphela kepha futhi kuthuthukisa umsebenzi wezinso, ukuhlinzeka iziguli ngamathuba amaningi okuqhubeka nokwelashwa okwengeziwe.

IbhayisikileIngabe umuthi we-peptide owenziwe we-peptide ohlukaniswe njenge-thrombin inhibitor eqondile, esetshenziselwa ukwelashwa okungama-anticonuagulant, ikakhulukazi kuma-syndromes acute acinomes (ACS) kanye nokungenelela kwe-coronary (PCI). I-Thrombin idlala indima ebalulekile kwinqubo yokuhlangana kwegazi ngokuguqula i-fibrinogen ibe yi-fibrin, okuholela ekwakhekeni kwe-rumbus. IBivilirudin isebenza ngokubopha ngqo esizeni esisebenzayo se-thrombin, kuvimbela umsebenzi wayo, ngaleyo ndlela kufezekisa imiphumela ye-anticoagulant.

1. Ukuvinjwa okuqondile kwe-thrombin: I-BiviliRudin ibopha ngqo esikhungweni esisebenzayo se-thrombin, ivimbe ukusebenzisana kwayo nge-fibrinogen. Lokhu okubophayo kucacisiwe kakhulu, okuvumela i-bivilibudin ukuthi ivimbela zombili i-thrombin yamahhala futhi i-thrombin isivele iboshelwe kuma-cloots. Ngenxa yalokho, iBivilirudin ivimbela ngempumelelo ukwakheka kwama-clots amasha nokunwetshwa kwabakhona.
2. Ukuqala okusheshayo nokulawulwaI-BiviliRudin inokuqala okusheshayo kwesenzo, kukhiqiza ngokushesha imiphumela ye-anticoagulant ekuphathweni kwe-intravenous. Uma kuqhathaniswa nendabuko yendabuko ye-thrombin inhibitors (efana ne-heparin), isenzo se-bivilirudin sizimele nge-antithrombin III futhi sinikeze ukulawulwa okungcono. Lokhu kusho ukuthi imiphumela yayo ye-anticoagulant ibonakala kakhulu futhi kulula ukuyiphatha, ikakhulukazi ezimweni zemitholampilo ezidinga ukuphathwa okuqondile kwesikhathi sokuhlangana, njengezinqubo ze-PCI.
3. Impilo emfushaneI-BiviliRudin inempilo emfushane efishane, cishe imizuzu engama-25, ivumela imiphumela yayo ye-anticoagulant ukuba ichithe ngokushesha ngemuva kokuyekiswa ngemuva kokuyekiswa. Lesi sici sisizonke iziguli ezidinga ama-anticoaguagulation amafushane kodwa aqinile, njengakwezinqubo zokungenelela kwe-coronary.
4. Ingozi esopha kancane: Ngenxa yezakhiwo zayo, iBivilirudin ihlinzeka nge-anticoaguagun ephumelelayo enengozi ephansi yokopha. Ucwaningo selukhombisile ukuthi iziguli eziphathwe nge-bivilibudin zinezigameko eziphansi zezinkinga zokopha uma ziqhathaniswa nalabo abathola i-heparin ehlanganiswe ne-GP IIB / III ENSITOR. Lokhu kwenza i-bivilibudin i-anticoagulant ephephile futhi ephumelelayo yeziguli ze-ACS nase-PCI.

Ngokufingqwa, iBivilirudin, njenge-Direct Thrombin Inhibitor, inikeza indlela ehlukile yokwenza isenzo kanye nezinzuzo zomtholampilo. Akugcini ngokuvimbela ngempumelelo i-thrombin ukuvikela ukwakheka kwe-clot kodwa futhi inezinzuzo ezinjengokuqala okusheshayo, impilo emfushane, kanye nengozi enopha. Ngakho-ke, iBivilirudin isetshenziswa kabanzi ekwelapheni ama-syndromes acute acute futhi ngesikhathi sokungenelela kwe-coronary. Kodwa-ke, naphezu kwephrofayili yayo yokuphepha ephezulu, kufanele isetshenziswe ngaphansi kokuholwa nguchwepheshe wezokunakekelwa kwempilo ukuqinisekisa ukuphepha kanye nokusebenza ngempumelelo.

I-OctreotideIngabe i-octapeptide yokwenziwa ilingisa isenzo se-somatostatin yemvelo. I-Somatostatin ihormone etholwe yi-hypothalamus nezinye izicubu ezivimbela ukutholakala kwama-hormone ahlukahlukene, kufaka phakathi i-hormone yokukhula, i-insulin, i-glucabagon, nama-hormone esisukwini. I-OCETREIDIDIDIDE isetshenziswa kabanzi emdlalweni wemitholampilo yokwelashwa kwezimo ezahlukahlukene, ikakhulukazi labo abadinga ukulawula imfihlo yama-hormone kanye nezimpawu ezihlobene ne-tumor.

1. Ukwelashwa kwe-acromegaly: I-Acromegaly yisimo esibangelwa imfihlo ngokweqile yokukhula kwama-hormone akhula, imvamisa ngenxa ye-petaitary Adenoma. I-OCTReotide isiza ukwehlisa amazinga okukhula kwama-hormone kanye nokukhula okufana ne-insulin-1 (IGF-1) egazini ngokuvimbela ukuthuthuka kwama-hormone okukhula, njengokukhulisa izandla nezinyawo, izinguquko ezicini zobuso , nobuhlungu obuhlangene.
2. Ukwelashwa kwe-carcinoid syndrome: I-Carcinoid Syndrome ibangelwa yimfihlo ngokweqile ye-serotonin nezinye izinto ezi-bioctionestinal carcinoid Tumors, okuholela ezimpawuni ezifana nesifo sohudo, ukugcwala kanye nesifo senhliziyo. I-Octreotide ilawula ngempumelelo izimpawu ze-carcinoid syndrome ngokuvimbela ukucasha kwalezi zindondo nezinto, ngaleyo ndlela kuthuthukise ikhwalithi yempilo yeziguli.
3. Ukwelashwa kwe-gastroenteropancreatic neuroendocrine tumors (GEP-NETS): Ama-Gep-Nets ayihlobo olungavamile lwesimila esivame ukuvela ephepheni lesisu noma amanyikwe. I-OCTREIDIDIDE isetshenziselwa ukulawula ukukhula kwalezi zimpawu nezimpawu abazibangela, ikakhulukazi kuma-tumor asebenzayo athola ama-hormone amakhulu. Ngokuvimbela ama-hormone athenjelwe amathumbu, i-octreotide inganciphisa ukwenzeka kwezimpawu futhi, kwezinye izikhathi, ukukhula kwesimila.
4. Ezinye izinhlelo zokusebenza: Ngaphandle kokusetshenziswa okuyisisekelo okushiwo ngenhla, i-OCTREIDIDE isetshenziselwa ukwelapha ukuphazamiseka kwe-endocrine okungavamile, njenge-insulinomas, ama-glucagonas, nama-vipomas (ama-tumor alandela i-vasoactinal peptide). Ngaphezu kwalokho, i-Octreotide ingasetshenziswa ekwelapheni izimo ze-hemorrhagic ezinobunzima, njengokulawula ukopha kwe-uppercroidwenal kanye nokopha okuqabulekile kwe-esophageal.

Sekukonke, i-OCTREITIDIDIDIDIDIDIDE inikezela ngokwelashwa okusebenzayo ngokuvimbela ukutholakala kwama-hormone ahlukahlukene, ikakhulukazi ekuphatheni izifo kanye nezimpawu ezihlobene ne-hormone secretion. Kodwa-ke, njengoba i-OCTREITIDIDIDIDE ingadala imiphumela emibi, njengokungakhululeki kwesisu, ukwakheka kwe-gallstone, kanye nezinguquko kumazinga we-glucose egazini, ukuqapha ngokucophelela nangokwelashwa ngaphansi kokuholwa ngudokotela kuyadingeka.