1ml:4μg / 1ml:15μg Amandla

Inkomba:

IZIKHOMBISO NOKUSETSHENZISWA

I-Hemophilia A: I-Desmopress ku-Acetate Injection 4 mcg/mL ikhonjiswe ezigulini ezine-hemophilia A ene-factor VIII coagulant umsebenzi amazinga angaphezu kuka-5%.

I-Desmopress emjovweni we-acetate ngokuvamile izogcina i-hemostasis ezigulini ezine-hemophilia A phakathi nezinqubo zokuhlinzwa kanye nangemuva kokuhlinzwa lapho ilawulwa imizuzu engu-30 ngaphambi kwenqubo ehleliwe.

I-Desmopress emjovweni we-acetate izophinda imise ukopha ezigulini ezine-hemophilia A ezineziqephu zokulimala okuzenzakalelayo noma okubangelwa ukuhlukumezeka okufana ne-hemarthroses, i-hematomas ye-intramuscular noma ukopha kwe-mucosal.

I-Desmopress emjovweni we-acetate ayibonisiwe ekwelapheni i-hemophilia A enamazinga omsebenzi we-factor VIII coagulant alingana noma angaphansi kuka-5%, noma ekwelapheni i-hemophilia B, noma ezigulini ezinamasosha omzimba e-factor VIII.

Ezimweni ezithile zomtholampilo, kungase kuthethelelwe ukuzama i-desmopress kumjovo we-acetate ezigulini ezinamazinga e-factor VIII phakathi kuka-2% kuya ku-5%; Nokho, lezi ziguli kufanele ziqashwe ngokucophelela. Isifo sika-von Willebrand (Uhlobo I): I-Desmopres s kumjovo we-acetate 4 mcg/mL ikhonjiswe ezigulini ezine-von Willebrand's disease (Uhlobo I) oluthambile kuya kolumaphakathi (Uhlobo I) olunamazinga e-factor VIII angaphezu kuka-5%. I-Desmopress emjovweni we-acetate ngokuvamile izogcina i-hemostasis ezigulini ezinesifo sika-von Willebrand esimaphakathi kuya kokumaphakathi phakathi nezinqubo zokuhlinzwa nangemuva kokuhlinzwa lapho kulawulwa imizuzu engama-30 ngaphambi kwenqubo ehleliwe.

I-Desmopress emjovweni we-acetate ngokuvamile izomisa ukopha ezigulini zika-von Willebrand ezimaphakathi kuya kwezilingene ezineziqephu zokulimala okuzenzakalelayo noma okubangelwa ukuhlukumezeka okufana ne-hemarthroses, i-hematoma ye-intramuscular noma ukopha kwe-mucosal.

Lezo ziguli zesifo sika-von Willebrand okungenzeka mancane kakhulu ukuthi ziphendule yilezo ezine-homozygous von Willebrand's disease enzima ne-factor VIII coagulant kanye ne-factor VIII von.

Amazinga e-Willebrand factor antigen angaphansi kuka-1%. Ezinye iziguli zingase ziphendule ngendlela eguquguqukayo kuye ngohlobo lokukhubazeka kwamangqamuzana ezinakho. Isikhathi sokopha nomsebenzi we-factor VIII coagulant, umsebenzi we-ristocetin cofactor, kanye ne-von Willebrand factor antigen kufanele kuhlolwe ngesikhathi sokuphathwa kwe-desmopress kumjovo we-acetate ukuze kuqinisekiswe ukuthi amazinga anele ayafinyelelwa.

I-Desmopress emjovweni we-acetate ayibonisiwe ekwelapheni isifo esinzima sakudala sika-von Willebrand (Uhlobo I) nalapho kukhona ubufakazi bohlobo olungavamile lwengqamuzana lwe-factor VIII antigen.

I-Diabetes Insipidus: I-Desmopress kumjovo we-acetate 4 mcg/mL iboniswa njenge-antidiuretic replacement therapy ekuphathweni kwe-central (cranial) yesifo sikashukela insipidus kanye nokuphathwa kwe-polyuria ne-polydipsia yesikhashana kulandela ukuhlukumezeka kwekhanda noma ukuhlinzwa esifundeni se-pituitary.

I-Desmopress kumjovo we-acetate ayisebenzi ekwelapheni i-nephrogenic diabetes insipidus.

I-Desmopress ku-acetate iyatholakala futhi njengokulungiswa kwe-intranasal. Kodwa-ke, le ndlela yokubeletha ingaba sengozini ngenxa yezizathu ezihlukahlukene ezingenza ukudonsa emakhaleni kungasebenzi noma kungafaneleki.

Lokhu kuhlanganisa ukumuncwa okungekuhle emakhaleni, ukuminyana nokuvaleka kwamakhala, ukuphuma kwamanzi emakhaleni, i-atrophy ye-mucosa yamakhala, kanye ne-atrophic rhinitis enzima. Ukulethwa emakhaleni kungase kungafaneleki lapho kukhona izinga lokuqaphela elikhubazekile. Ukwengeza, izinqubo zokuhlinza i-cranial, njenge-transsphenoidal hypophysectomy, zakha izimo lapho enye indlela yokuphatha idingeka khona njengezimo zokupakishwa kwamakhala noma ukululama ngemva kokuhlinzwa.

IZIQINISEKISO

I-Desmopress kumjovo we-acetate i-4 mcg/mL iyavinjelwa kubantu abane-hypersensitivity eyaziwayo ku-desmopress ku-acetate noma kunoma yiziphi izingxenye ze-desmopress kumjovo we-acetate 4 mcg/mL.

I-Desmopress emjovweni we-acetate ayivunyelwe ezigulini ezinokukhubazeka okumaphakathi kuya kokuqina kwezinso (kuchazwa njengokuvunyelwa kwe-creatinine ngaphansi kuka-50ml/min).

I-Desmopress kumjovo we-acetate iyaphikiswa ezigulini ezine-hyponatremia noma umlando we-hyponatremia.