I-1mL: 4μg / 1ml: 15μg amandla

Isibonakaliso:

Izinkomba nokusetshenziswa

IHemophilia A: Desmopress in Acetate umjovo 4 MCG / ML kuboniswa iziguli ezine-hemophilia a ne-Factor VIII amazinga ahlanganisiwe womsebenzi omkhulu kuno-5%.

I-Desmopress emjovo we-acetate ivame ukugcina i-hemostasis ezigulini ezine-hemophilia a Ngezinqubo zokuhlinza futhi nge-postitatively lapho ilawulwa imizuzu engama-30 ngaphambi kwenqubo ehleliwe.

I-Desmopress emjovo we-acetate izophinde iyeke ukopha e-hemophilia iziguli ezineziqephu zokulimala okuzenzakalelayo noma okuhlukumezekile okwenziwe ngama-hemarthroses, i-hematomas ye-mucosal noma ukopha i-mucosal noma ukopha i-mucosal noma ukopha i-mucosal noma ukopha i-mucosal noma ukopha i-mucosal noma ukopha mucosal noma ukopha i-mucosal noma ukopha i-mucosal noma ukopha i-mucosal.

I-Desmopress emjovo we-Acetate ayikhonjiswanga ekwelapheni i-hemophilia A nge-factor viii imisebenti yobumbano yemikhumbi elingana noma ngaphansi kwama-5%, noma ekwelapheni kwe-hemophilia b, noma ezigulini ezine-factor viiii ama-antibodies.

Kwezinye izimo zemitholampilo, kungahle kube nesizathu sokuzama i-desmopress emjovo we-acetate ezigulini ezinamazinga we-2% kuya ku-5%; Kodwa-ke, lezi ziguli kufanele zibhekwe ngokucophelela. Isifo sika-Von Willebrand (Uhlobo I): Ama-Desmopres S ku-Acetate Umjovo 4 MCG / ML kuboniswa iziguli ezinomnene kuya ku-Classic von Vourbrand isifo (uhlobo i) ngamazinga we-5%. I-Desmopress emjovo we-acetate ivame ukugcina i-hemostasis ezigulini ezinomnene kuya ku-von willebrand isifo se-von willebrand ngezinqubo zokuhlinzwa kanye ne-postperatively lapho kulawulwa yimizuzu engama-30 ngaphambi kwenqubo ehleliwe.

I-Desmopress emjovo we-acetate ivame ukuyeka ukopha iziguli ezimnene ukuya kwezinye iziqephu zokulimala okuzenzakalelayo noma okuhlukumezeka okubangelwa okufana nama-hemarthroses, i-hematomas ye-mucosal noma ukopha i-mucosal.

Lezo ziguli ze-von willebrand okungenani okungenzeka ukuthi ziphendule yilezo ezinesifo esinamandla se-homozygous vown vonberbland ngomsebenzi wobumbano lwe-factor viii

Amazinga we-Wilbrand factor antigen angaphansi kwe-1%. Ezinye iziguli zingaphendula ngendlela ehlukahlukene ngokuya ngohlobo lwesimo se-molecular abanalo. Isikhathi sokopha kanye neFactor VIII umsebenzi ohlanganayo, umsebenzi we-ristocetin cofactor, kanye ne-von willebrand factor antigen kufanele ihlolwe ngesikhathi sokuphathwa kwe-desmopress emjovo we-acetate ukuqinisekisa ukuthi amazinga anele ayatholakala.

I-Desmopress emjovo we-acetate ayikhonjiswanga ukwelashwa kwesifo esinamandla se-von willebrand (uhlobo i) futhi lapho kunobufakazi befomu le-factor viii antigen.

Isifo Sikashukela Insiphidus: I-Desmopress in Acetate Umjovo 4 MCG / ML kukhonjiswa ukwelashwa okubuyiselwa emuva kwe-Central (Cranial) sikashukela Insiphidus kanye nokuphathwa kwe-polyuria yesikhashana kanye nokuhlinzwa esifundeni sasePutuitary.

I-Desmopress emjovo we-acetate ayisebenzi ngentengo yokwelashwa kwesifo sikashukela se-nephrogenic insipIdus.

I-Desmopress e-Acetate iyatholakala futhi njengokulungiselela okwenzeka nge-intranasal. Kodwa-ke, le ndlela yokulethwa ingabekelwa phansi yizici ezahlukahlukene ezingenza ukungasebenzi kahle kwamakhala noma kungafanele.

Lokhu kufaka phakathi ukumuncwa okuhle kwe-intranasal, ukugcwala kwamakhala kanye nokuvinjwa, ukukhishwa kwamakhala, i-atrophy ye-mucosa yamakhala, kanye ne-atrophic rhinitis enzima. Ukulethwa kwe-Intranasal kungenzeka kungafanele lapho kunezinga elithile lokuqonda. Ngaphezu kwalokho, izinqubo zokuhlinzwa ze-cranial, njenge-transpphenoidal hypophypectomy, dala izimo lapho kudingeka khona indlela ehlukile yokuphatha njengoba zibhekene nezimo zokupakishwa kwamakhala noma ukululama ekuhlinzekeni kwamakhala noma ukululama ekuhlinzeni amakhala.

Contraindications

I-Desmopress in Acetate umjovo 4 MCG / ML i-contraimbicated kubantu abane-hypersensitivity eyaziwayo e-acetate acetate noma kunoma yiziphi izakhi ze-desmopress in acetate umjovo we-acetate 4 MCG / ML.

I-Desmopress in Acetate It Contrainding ezigulini ezinokulinganiswa okulinganiselwe kuya ekulimaleni okunzima kwe-renal (kuchazwe njenge-creatinine imvume ngaphansi kwe-50ml / min).

I-Desmopress in Acetate umjovo ihlanganiswe neziguli nge-hyponatreamia noma umlando we-hyponatremia.