Linaclotide
Awọn ọrọ-ọrọ
- LinaclotideIpilẹ
- julọ ti ifarada owo
- CAS # 851199-59-2
Awọn alaye kiakia
- Orukọ: Linaclotide
- CasNo: 851199-59-2
- Ilana molikula: C59H79N15O21S6
- Irisi: funfun lulú
- Ohun elo: lo fun Curing àìrígbẹyà
- Akoko Ifijiṣẹ: gbigbe kiakia
- PackAge: ni ibamu si awọn ibeere alabara
- Ibudo: Shenzhen
- Agbara iṣelọpọ: Kilogram 1 / osù
- Mimọ: 98%
- Ibi ipamọ: 2 ~ 8 ℃. ni idaabobo lati ina
- Gbigbe: nipasẹ afẹfẹ
- Iwọn Iwọn: 1 Giramu
Iwaju
Awọn alaye
Ọja: Linaclotide
Itumọ ọrọ: Linaclotide Acetate
CAS No.: 851199-59-2
Ilana molikula: C59H79N15O21S6
Iwọn Molikula: 1526.8
Irisi: funfun lulú
Mimọ:>98%
Tẹle: NH2-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH
Linaclotide jẹ sintetiki, peptide amino acid mẹrinla ati agonist ti iru guanylate cyclase intestinal C (GC-C), eyiti o ni ibatan si ipilẹ ti idile guanylin peptide, pẹlu asiri, analgesic ati awọn iṣẹ laxative. Lori iṣakoso ẹnu, linaclotide sopọ mọ ati mu awọn olugba GC-C ṣiṣẹ ti o wa lori oju itanna ti epithelium oporoku. Eyi mu ifọkansi ti intracellular cyclic guanosine monophosphate (cGMP), eyiti o jẹ lati guanosine triphosphate (GTP). cGMP mu ki cystic fibrosis transmembrane conductance regulator ṣiṣẹ (CFTR) ati ki o ṣe itusilẹ ti kiloraidi ati bicarbonate sinu lumen ifun. Eyi n ṣe agbejade iyọkuro iṣuu soda sinu lumen ati awọn abajade ni alekun yomijade ifun inu. Nikẹhin eyi n yara gbigbe GI ti awọn akoonu inu ifun, ṣe ilọsiwaju gbigbe ifun ati ki o tu àìrígbẹyà. Awọn ipele cGMP extracellular ti o pọ si le tun ṣe ipa ipa antinociceptive, nipasẹ ọna ti ko ti ni kikun sibẹ, ti o le kan iyipada ti awọn nociceptors ti a rii lori awọn okun irora afferent colonic. Linaclotide ti gba diẹ lati inu GI ngba.
