Nge-2022, i-Shenzhen Jymed Jo., I-LTD. (i-Ltd. (i-LTD. Ukuphononongwa kwengqiqo, kwaye imeko yangoku ngu "A". I-JYMED PEPTIDE iye yaba yenye ye-batch yokuqala yomenzi we-semaglutide e-china ukuya kudlula uphononongo lwe-US.

Nge-16 kaFebruwari, 2023, iwebhusayithi esemthethweni yeZiko loVavanyo lweziyobisi lolawulo lweziyobisi ubhengeze ukuba i-Semaglute API [Inombolo yoBhaliso: y2023] ibhaliswe kwaye ibhaliwe nguHibene Co., ifumene yamkelwe. I-JYMED PEPTIDE iye yaba ngomnye wabavelisi bokuqala bezinto eziveleyo zeziyobisi ezinokuthengiswa kwentengiso zale mveliso zamkelwe eChina.

Malunga ne-semaglutide
I-Semaglutide yi-GLP-1 i-Agonist Agonist iphuhliswe yiNovo Nordk (Novo Nordk). Iyeza elinokunyusa imetabolism ye-glucolism ngokuvuselela iiseli ze-pancrereac ukuya kwi-CECRIN CECRIN, kwaye ithintele imfihlo ye-GLucagon evela kwiiseli ze-αncrean ukusuka kwiswekile yegazi ye-pancreatic. Ukongeza, kunciphisa ukutya ngokutya ngokuncitshiswa komdla kunye nokuncipha kokucothisisa esiswini, okokugqibela kunciphisa amafutha omzimba kunye noGawulayo ngokunciphisa umzimba.
1. Ulwazi olusisiseko
Ngokwembono yembono yesakhiwo, xa kuthelekiswa ne-liraglutide, olona tshintsho lukhulu lwe-semaglutide longezwe kwikhonkco lendlela yeLisine, kunye nePalmic Acid ithe yathatyathe indawo yi-Octadecanediociocioc acid. UAlanine wathatyathelwa indawo yi-AB, ekwandisa kakhulu isiqingatha sobomi be-semaglutide.

Isakhiwo se-SEMAGLKID

2. Iphawu
1) I-Semaglutide inokunciphisa umngcipheko weziganeko zentliziyo kwizigulana ezine-T2D.
2) I-Semaglutide iphantsi iswekile yegazi ngokukhuthaza i-insulin ye-insulin kunye nokunciphisa ukhuseleko lwe-glucagon. Xa iswekile yegazi iphezulu, ukufihlakala kwe-insulin kukhuthazekile kwaye i-glucagon ye-glucagon ayithintelwanga.
I-3) I-Novo I-Novo Ahdsisk Ulingo loovulindlela lubonise ukuba ulawulo lwe-Oral lwe-Semaglutide 1mg, i-0.5mg ineziphumo ezingcono ze-hypoglycemic kunye ne-dulaglutide) 1.5mg, 0.75mg.
I-3) I-Oral Semaglutide likhadi leTrump ye-novo rddisk. Ulawulo lomlomo kanye ngosuku lungasusa into yokungasebenzi kunye nokuthuthunjiswa kwengqondo okubangelwa yinaliti, kwaye ingcono kune-liraglutide (inaliti kube kanye ngeveki). Iziphumo ze-hypoglycemic kunye nezisiqhelo zexabiso le-witpystream ezinje, i-Phulagllozin (SGLT-2) kunye ne-shitloripn (DPP-4) inomtsalane kakhulu kwizigulana kunye noogqirha. Xa kuthelekiswa nemisebenzi yentsungwana, iifom zomlomo ziya kuphucula kakhulu ukusetyenziswa kwekliniki ye-semaglutide.

3. Isishwankathelo
Kuthe ngqo ngenxa yokusebenza kwayo ngokugqibeleleyo kwi-hypoglycemic, ukunciphisa umzimba, ukhuseleko kunye nezibonelelo zentliziyo ukuba i-semaglutide ibe yindawo enkulu yentengiso.