U-Erica Prouty, i-PharmD, ngusokhemisti oqeqeshiweyo onceda abaguli ngamayeza kunye neenkonzo zekhemesti eMntla Adams, Massachusetts.
Kwizifundo zezilwanyana ezingezona zomntu, i-semaglutide ibonakaliswe ukuba ibangele i-C-cell thyroid tumors kwiigundane. Nangona kunjalo, akucaci ukuba lo mngcipheko udlulela ebantwini. Nangona kunjalo, i-semaglutide ayifanele isetyenziswe kubantu abanembali yomntu okanye yentsapho ye-medullary thyroid cancer okanye kubantu abane-multiple endocrine neoplasia type 2 syndrome.
I-Ozempic (semaglutide) isiyobisi esisetyenziswayo kunye nokutya kunye nokuzivocavoca ukulawula amanqanaba eswekile yegazi kubantu abanesifo sikashukela sohlobo lwe-2. Ikwasetyenziselwa ukunciphisa umngcipheko weziganeko ezinzulu ze-cardiovascular ezifana ne-stroke okanye ukuhlaselwa yintliziyo kubantu abadala abanesifo seswekile se-2 kunye nesifo senhliziyo.
I-ozone ayiyo insulin. Isebenza ngokunceda i-pancreas ikhuphe i-insulin xa amanqanaba eswekile yegazi ephezulu kwaye ngokuthintela isibindi ekwenzeni kunye nokukhulula iswekile eninzi. I-ozone iphinda icuthe ukuhamba kokutya ngesisu, ukunciphisa ukutya kunye nokubangela ukulahleka kwesisindo. I-Ozempic ikudidi lwamachiza abizwa ngokuba yi-glucagon-like peptide 1 (GLP-1) receptor agonists.
I-Ozempic ayilunyangi uhlobo loku-1 lweswekile. Ukusetyenziswa kwizigulane ezine-pancreatitis (ukuvuvukala kwe-pancreas) akuzange kufundwe.
Ngaphambi kokuba uqale ukuthatha i-Ozempic, funda incwadana yolwazi lwesigulana kunye nomyalelo wakho kwaye ubuze ugqirha wakho okanye usokhemisti nayiphi na imibuzo onokuba nayo.
Qinisekisa ukuthatha eli yeza njengoko kuyalelwe. Abantu ngokuqhelekileyo baqala ngedosi ephantsi kwaye banyuse ngokuthe ngcembe njengoko bayalelwa ngumboneleli wabo wezempilo. Nangona kunjalo, akufanele utshintshe idosi yakho ye-Ozempic ngaphandle kokuthetha nomsebenzi wakho wezempilo.
I-Ozempic sisitofu esingaphantsi kwesikhumba. Oku kuthetha ukuba itofwe phantsi kwesikhumba sethanga, ingalo yangaphezulu, okanye yesisu. Abantu badla ngokufumana idosi yabo yeveki ngosuku olunye lweveki. Umboneleli wakho wezempilo uya kukuxelela apho kufuneka utofe khona ithamo lakho.
Isithako se-Ozempic, i-semaglutide, ikwafumaneka kwifomu yethebhulethi phantsi kwegama lebrendi i-Rybelsus nakwenye indlela etofwayo phantsi kwegama lebrendi ethi Wegovy. Musa ukusebenzisa iintlobo ezahlukeneyo ze-semaglutide ngexesha elinye.
Buza umboneleli wakho wezempilo ukuba kufuneka uyijonge kangaphi iswekile yegazi lakho. Ukuba iswekile yegazi iphantsi kakhulu, unokuziva ugodola, ulambile, okanye unesiyezi. Umboneleli wakho wezempilo uya kukuxelela indlela yokuphatha iswekile yegazi ephantsi, ngokuqhelekileyo ngexabiso elincinci lejusi ye-apula okanye iipilisi ze-glucose ezikhawulezayo. Abanye abantu basebenzisa iglucagon kagqirha ngenaliti okanye ngesitshizi ngeempumlo ukunyanga iimeko ezingxamisekileyo ze-hypoglycemia.
Gcina i-Ozempic kwipakethe yokuqala kwifriji, ekhuselwe ekukhanyeni. Musa ukusebenzisa iipeni eziphelelwe lixesha okanye ezikhenkcezisiweyo.
Unokuphinda usebenzise ipeni amaxesha amaninzi ngenaliti entsha kwithamo ngalinye. Ungaze uphinde usebenzise inaliti. Emva kokusebenzisa ipeni, susa inaliti kwaye ubeke inaliti esetyenzisiweyo kwisitya esibukhali ukuze ulahlwe ngokufanelekileyo. Izikhongozeli zokulahlwa kweSharps ziqhele ukufumaneka kwiikhemesti, iinkampani ezinikezela ngezonyango, kunye nababoneleli bezempilo. Ngokwe-FDA, ukuba isikhongozeli sokulahla izinto ezibukhali asifumaneki, ungasebenzisa isikhongozeli sasekhaya esihlangabezana nezi mfuno zilandelayo:
Xa ugqibile ukusebenzisa ipeni, buyisela ikepusi kwaye uyibuyisele efrijini okanye kwiqondo lokushisa. Yigcine kude nobushushu okanye ekukhanyeni. Yilahle ipeni kwiintsuku ezingama-56 emva kokusetyenziswa kokuqala okanye ukuba kukho ngaphantsi kwe-0.25 milligrams (mg) esele (njengoko kubonisiwe kwikhawunta yedosi).
Gcina i-Ozempic kude nabantwana kunye nezilwanyana zasekhaya. Ungaze wabelane nabanye abantu ngepeni ye-Ozempic, nokuba utshintsha inaliti.
Ababoneleli ngezempilo banokusebenzisa i-Ozempic ngaphandle kweleyibhile, okuthetha ukuba kwiimeko ezingachongwanga ngokuthe ngqo yi-FDA. I-Semaglutide ngamanye amaxesha isetyenziselwa ukunceda abantu ukulawula ubunzima babo ngokudibanisa ukutya kunye nokuzivocavoca.
Emva kwedosi yokuqala, i-Ozempic ithatha intsuku enye ukuya kwezintathu ukufikelela kumanqanaba aphezulu emzimbeni. Nangona kunjalo, i-Ozempic ayiyehliseli iswekile yegazi kwidosi yokuqala. Kusenokufuneka ujongwe iswekile yakho emva kweeveki ezisibhozo zonyango. Ukuba idosi yakho ayisebenzi kweli nqanaba, umboneleli wakho wezempilo unokunyusa umthamo wakho weveki kwakhona.
Olu alulo uluhlu olupheleleyo lwemiphumo emibi, ezinye iziphumo zecala zingenzeka. Ingcali yezempilo inokukuxelela malunga neziphumo ebezingalindelekanga. Ukuba ufumana ezinye iziphumo, qhagamshelana nomboneleli wakho wezempilo. Unokuxela iziphumo ebezingalindelekanga kwi-FDA kwi-fda.gov/medwatch okanye ngokufowunela 1-800-FDA-1088.
Fowunela umboneleli wakho wezempilo ngoko nangoko ukuba uneziphumo ebezingalindelekanga ezimandundu. Ukuba iimpawu zakho zisongela ubomi okanye ucinga ukuba ufuna unyango oluphuthumayo, fowunela 911. Iziphumo ezibi kakhulu kunye neempawu zabo zingabandakanya oku kulandelayo:
Xela iimpawu kumboneleli wakho wezempilo okanye ufune ukhathalelo olungxamisekileyo ukuba luyimfuneko. Biza ugqirha wakho ngoko nangoko ukuba uneempawu ze-thyroid tumor, kubandakanya:
I-ozone inokubangela ezinye iziphumo ebezingalindelekanga. Fowunela umboneleli wakho wezempilo ukuba uneengxaki ezingaqhelekanga ngelixa uthatha eli yeza.
Ukuba ufumana iziphumo ezibi kakhulu, wena okanye umboneleli wakho wezempilo unokufaka ingxelo kunye neNkqubo yeNgxelo yeMedWatch yeMedWatch yeMedWatch okanye umnxeba (800-332-1088).
Umthamo weli yeza uya kwahluka kwizigulane ezahlukeneyo. Landela imiyalelo kagqirha wakho okanye imiyalelo kwileyibhile. Olu lwazi lungezantsi lubandakanya kuphela idosi eqhelekileyo yeli yeza. Ukuba idosi yakho yahlukile, musa ukuyitshintsha ngaphandle kokuba ugqirha wakho akuxelele ukuba wenze njalo.
Ubungakanani beyeza olithathayo buxhomekeke kumandla iyeza. Kwakhona, iidosi ozithathayo suku ngalunye, ixesha elivumelekileyo phakathi kweedosi, kunye nokuba uthatha ixesha elingakanani iyeza kuxhomekeke kwingxaki yezonyango oyisebenzisela iyeza.
Kwezinye iimeko, kunokuba yimfuneko ukutshintsha okanye ukulungisa unyango nge-Ozempic. Abanye abantu kunokufuneka balumke xa bethatha eli yeza.
Izifundo zezilwanyana ezingezona zomntu zibonisa ukuba ukuvezwa kwe-semaglutide kunokubangela ingozi kwi-fetus. Nangona kunjalo, ezi zifundo azithathi ndawo izifundo zabantu kwaye azisebenzi ebantwini.
Ukuba ukhulelwe okanye uceba ukukhulelwa, nceda uqhagamshelane nomboneleli wakho wezempilo ukuze ufumane iingcebiso. Unokudinga ukuyeka ukuthatha i-Ozempic ubuncinane kwiinyanga ezimbini ngaphambi kokuba ukhulelwe. Abantu abakubudala bokuzala kufuneka basebenzise ulawulo-nzala olusebenzayo ngelixa bethatha i-Ozempic kwaye ubuncinane iinyanga ezimbini emva kwedosi yokugqibela.
Ukuba uncancisa, nceda udibane nochwepheshe bakho bezempilo ngaphambi kokusebenzisa i-Ozempic. Akwaziwa ukuba u-Ozempic uyaphumelela kubisi lwebele.
Abanye abantu abadala abaneminyaka engama-65 nangaphezulu banomdla kakhulu kwi-Ozempic. Kwezinye iimeko, ukuqala kwidosi ephantsi kwaye ngokuthe ngcembe ukunyusa kunokunceda abantu abadala.
Ukuba uphosa ithamo le-Ozempic, yithathe ngokukhawuleza kwisithuba seentsuku ezintlanu zedosi ephosiweyo. Emva koko phinda uqalise ucwangciso lwakho lweveki. Ukuba ngaphezulu kweentsuku ezintlanu zidlulile, tsiba idosi ephosiweyo kwaye uqalise kwakhona idosi yakho ngosuku olucwangcisiweyo oluqhelekileyo lwedosi yakho.
Ukusetyenziswa kakubi kwe-Ozempic kunokubangela isicaphucaphu, ukugabha, okanye iswekile ephantsi egazini (hypoglycemia). Ngokuxhomekeke kwiimpawu zakho, unokunikwa uncedo lwenkxaso.
Ukuba ucinga ukuba wena okanye omnye umntu unokuthi ugqithise i-Ozempic, tsalela umnikezeli wakho wezempilo okanye iziko lokulawula ubuthi (800-222-1222).
Kubaluleke kakhulu ukuba ugqirha wakho ahlole inkqubela yakho rhoqo ukuze aqinisekise ukuba eli yeza lisebenza ngokufanelekileyo. Uvavanyo lwegazi kunye nomchamo lunokufuneka ukujonga iziphumo ebezingalindelekanga.
Tshela ugqirha wakho ukuba ukhulelwe okanye uceba ukukhulelwa. Musa ukuthatha eli liyeza ubuncinane kwiinyanga ezi-2 ngaphambi kokuba uceba ukukhulelwa.
Ukhathalelo olungxamisekile. Ngamanye amaxesha unokufuna ukhathalelo olungxamisekileyo kwiingxaki ezibangelwa sisifo seswekile. Kufuneka uzilungiselele ezi meko zikaxakeka. Kucetyiswa ukuba uhlale unxibe isacholo seMedical Identification (ID) okanye intsimbi yomqala. Kwakhona, phatha kwi-wallet yakho okanye ukhuphe i-ID ethi unesifo seswekile kunye noluhlu lwawo onke amayeza akho.
Eli yeza linokunyusa umngcipheko wakho wokuphuhlisa amathumba e-thyroid. Tshela ugqirha wakho ngokukhawuleza ukuba une-lump okanye ukuvuvukala entanyeni okanye emqaleni wakho, ukuba unenkathazo yokugwinya okanye ukuphefumula, okanye ukuba ilizwi lakho liba nomsindo.
I-Pancreatitis (ukuvuvukala kwe-pancreas) kunokwenzeka xa usebenzisa eli yeza. Biza ugqirha wakho ngoko nangoko ukuba ufumana iintlungu eziqatha zesisu, ukugodola, ukuqunjelwa, isicaphucaphu, ukuhlanza, umkhuhlane, okanye isiyezi.
Biza ugqirha wakho ngoko nangoko ukuba unentlungu yesisu, umkhuhlane ophindaphindiweyo, ukuqunjelwa, okanye ukutyheli kwamehlo okanye ulusu. Ezi zinokuba ziimpawu zeengxaki ze-gallbladder ezifana ne-gallstones.
Eli yeza linokubangela i-diabetes retinopathy. Qhagamshelana nogqirha wakho ukuba unombono olumfiliba okanye naluphi na utshintsho lombono.
Eli liyeza alibangeli i-hypoglycemia (ishukela eliphantsi legazi). Nangona kunjalo, iswekile yegazi ephantsi inokuthi yenzeke xa i-semaglutide isetyenziswe kunye namanye amayeza okunciphisa iswekile yegazi, kuquka i-insulin okanye i-sulfonylureas. Iswekile yegazi ephantsi inokuthi yenzeke ukuba uyalibazisa okanye utsiba ukutya okanye i-snacks, usebenzise ngaphezu kwesiqhelo, usele utywala, okanye awukwazi ukutya ngenxa yesicaphucaphu okanye ukuhlanza.
Eli yeza linokubangela ukuphazamiseka okukhulu komzimba, kubandakanywa i-anaphylaxis kunye ne-angioedema, enokubeka ubomi esichengeni kwaye ifune unyango olukhawulezileyo. Biza ugqirha wakho ngokukhawuleza ukuba uhlakulela i-rash, i-itching, i-hoarseness, inkathazo yokuphefumula, inkathazo yokugwinya, okanye ukuvuvukala kwezandla zakho, ubuso, umlomo, okanye umqala ngelixa usebenzisa le mayeza.
Eli yeza linokubangela ukungasebenzi kakuhle kwezintso. Biza ugqirha wakho ngoko nangoko ukuba unegazi kumchamo wakho, ukunciphisa umchamo, ukuxubha kwemisipha, isicaphucaphu, ukuzuza ubunzima okukhawulezayo, ukuxhuzula, i-coma, ukuvuvukala kobuso bakho, amaqatha, okanye izandla, okanye ukudinwa okungaqhelekanga okanye ubuthathaka.
Eli yeza linokunyusa izinga lentliziyo yakho xa uphumle. Biza ugqirha wakho ngoko nangoko ukuba unentliziyo ekhawulezayo okanye eyomeleleyo.
I-Hyperglycemia (iswekile ephezulu egazini) ingenzeka ukuba awuthathi ngokwaneleyo okanye uphose idosi yeyeza lokuthomalalisa isifo seswekile, utya kakhulu okanye awulandeli isicwangciso sakho sokutya, unomkhuhlane okanye usulelo, okanye awuzilolongi kangangoko uqhele ukwenza. ingaba.
Eli yeza linokubangela ukucaphuka, ukucaphuka, okanye enye indlela yokuziphatha engaqhelekanga kwabanye abantu. Kwakhona kunokubangela ukuba abanye abantu babe neengcinga kunye notyekelo lokuzibulala, okanye badandatheke ngakumbi. Xelela ugqirha wakho ukuba uneemvakalelo zesiquphe okanye ezinamandla, kuquka iimvakalelo zovalo, umsindo, ukucaphuka, ugonyamelo, okanye uloyiko. Tshela ugqirha wakho ngokukhawuleza ukuba wena okanye umnakekeli wakho uqaphela nayiphi na le miphumo emibi.
Musa ukuthatha amanye amayeza ngaphandle kokuba uyalelwe ngugqirha wakho. Oku kubandakanya amayeza kagqirha kunye ne-over-the-counter (OTC) amayeza, kunye neyeza lezityalo okanye iivithamin.
Abanye abantu banokulumka malunga nokumisela i-ozone ukuba umboneleli wakho wezempilo uthatha isigqibo sokuba ikhuselekile. Le miqathango ilandelayo inokufuna ukuba uthathe i-Ozempic ngononophelo olukhulu:
I-ozone inokubangela i-hypoglycemia. Ukuthatha i-Ozempic namanye amayeza okwehlisa iswekile yegazi kunokonyusa umngcipheko weswekile yegazi ephantsi (iswekile yegazi ephantsi). Kusenokufuneka uhlengahlengise ithamo lamanye amayeza, njenge-insulin okanye amanye amayeza asetyenziselwa ukunyanga isifo seswekile.
Ngenxa yokuba i-ozone ilibazisa ukuphuma kwesisu, inokuphazamisa ukufunxa amayeza omlomo. Buza umboneleli wakho wezempilo ukuba uwacwangcisa njani amanye amayeza ngelixa uthatha i-Ozempic.
Amanye amayeza anokonyusa ingozi yeengxaki zezintso xa ethathwa ne-Ozempic. La machiza aquka:
Olu ayiloluhlu olupheleleyo lwentsebenziswano yeziyobisi. Okunye ukusebenzisana kweziyobisi kunokwenzeka. Xelela umboneleli wakho wezempilo malunga nawo onke amayeza owathathayo, kubandakanywa amayeza kagqirha kunye namayeza athengiswayo kunye neevithamini okanye izongezo. Oku kuqinisekisa ukuba umboneleli wakho wezempilo unolwazi aludingayo ukuze amisele i-Ozempic ngokukhuselekileyo.