Igama leMchiza: (S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2 -yl)amino)-1-methoxy-2-methyl-3-oxopropyl)p yrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide
Ubunzima beMolekyuli: 717.98
Ifomula: C39H67N5O7
CAS: 474645-27-7
Ukunyibilika: DMSO ukuya kuthi ga kwi-20 mM

I-Monomethyl Auristatin E yidolastatin-10i-peptide derivative ene-antimitotic enamandla kunye nomsebenzi onokubakho we-antineoplastic njengenxalenye ye-antibody-drug conjugate (ADC). I-Monomethyl auristatin E (MMAE) ibophelela kwi-tubulin, iibhloko ze-tubulin polymerization, kwaye inqanda ukubunjwa kwe-microtubule, okubangela ukuphazamiseka kokubili kwe-mitotic spindle assembly kunye nokubanjwa kweeseli ze-tumor kwisigaba se-M somjikelezo weseli. Ukunciphisa ubuthi kunye nokwandisa ukusebenza kakuhle,MMAEiyadityaniswa, ngekhonkco lepeptide elicandekayo, kwi-antibody ye-monoclonal ejolise ngokukodwa kwithumba lesigulana. I-linker izinzile kwi-extracellular milieu kodwa icoca ngokukhawuleza ukukhululaMMAEkulandela ukubophelela kunye nokufakwa ngaphakathi kwe-ADC ziiseli ekujoliswe kuzo.