Igama leekhemikhali: . -Yl) i-aminoct -1-I-200-2-methyl-3-onguPropyl) p yllulidin-1-YL
Ubunzima bemolekyuli: 717.98
IFomula: C39h67O7O7
CAS: 474645-27-7
Ukungasebenzi: I-DMSO ukuya kuthi ga kwi-20 mm

Monomethyl auristatin e nguI-Dolasitin-10I-Peptide ifumana umsebenzi onamandla o-antimitotic kunye nomsebenzi onokubakho we-antineplastistic njengenxalenye ye-antict-conjugate (i-ADC). Monomethyl auristatin e (Mmae) Ukubopha i-tublin, iibhloko ze-tubulin polymerization, kwaye uthintele ukwenziwa kwe-microtubule, ezikhokelela kuzo zombini ukuphazamiseka kweNdibano yeMittic Spindle kunye nokubanjwa kweeseli ze-TMOR kwisigaba se-TUTOR kwisigaba se-M. Ukunciphisa ububi kwaye kwandise ukusebenza kakuhle,MmaeIdityanisiwe, nge-Liker ye-COCTECIDE yePeptide, kwi-monoclonnika umntu ojolise ngqo kwi-tumor yesigulana. Isithandwa sizinzile kwi-sovercelliarl millieuu kodwa icocekile ukuba ikhululweMmaeUkulandela ukubopha kunye nokunikezelwa kwangaphakathi kwe-ADC ziiseli ekugxilwe kuzo.