Imveliso: Linaclotide
Isithethantonye: iLinaclotide Acetate
Inombolo yeCAS: 851199-59-2
Ifomula yeemolekyuli: C59H79N15O21S6
Ubunzima beMolekyuli: 1526.8
Imbonakalo: Umgubo omhlophe
Ubunyulu: >98%
Ulandelelwano: NH2-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH

I-Linaclotide i-synthetic, ishumi elinesine le-amino acid peptide kunye ne-agonist ye-intestinal guanylate cyclase uhlobo lwe-C (GC-C), ehambelana nolwakhiwo kwintsapho ye-guanylin peptide, kunye ne-secretagogue, i-analgesic kunye nemisebenzi ye-laxative. Ekulawuleni komlomo, i-linaclotide ibophelela kwaye isebenze i-GC-C i-receptors ebekwe kwindawo ye-luminal ye-epithelium yamathumbu. Oku kwandisa i-intracellular cyclic guanosine monophosphate (cGMP), ephuma kwi-guanosine triphosphate (GTP). I-cGMP ivuselela i-cystic fibrosis transmembrane conductance regulator (CFTR) kwaye ivuselela ukukhutshwa kwe-chloride kunye ne-bicarbonate kwi-lumen yamathumbu. Oku kukhuthaza ukukhutshwa kwe-sodium kwi-lumen kwaye kubangela ukwanda kwamathumbu emathunjini. Oku ekugqibeleni kukhawulezisa ukuhanjiswa kwe-GI yeziqulatho zamathumbu, kuphucula ukuhamba kwamathumbu kunye nokukhulula ukuqhina. Ukunyuka kwamanqanaba e-cGMP e-extracellular kungaphinda kusebenzise impembelelo ye-antinociceptive, ngokusebenzisa indlela engekacaciswanga ngokupheleleyo, enokuthi ibandakanye ukumodareyithwa kwee-nociceptors ezifunyenwe kwi-colonic afferent pain fibers. I-Linaclotide ifunxeka kancinci kwiphecana le-GI.