Jina la Kemikali:(S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-dimethyl-2-((S) -3-methyl-2-(methylamino)butanamido)lakini anamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoic asidi

Uzito wa Masi:731.96
Mfumo:C39H65N5O8
Nambari ya CAS:141205-32-5
Umumunyifu:DMSO hadi 20 mm

Shughuli ya Kibiolojia
Monomethyl auristatin F (MMAF) au desmethyl-auristatin F ni wakala wa anti-tubulini ambayo huzuia mgawanyiko wa seli kwa kuzuia upolimishaji wa tubulini. Ni mpyaauristatin derivativeiliyo na C-terminal phenylalanine iliyochajiwa ambayo hupunguza shughuli zake za cytotoxic ikilinganishwa na mwenzake ambaye hajachajiwa, monomethyl auristatin E (MMAE). Kwa kuongeza, kikundi cha amino cha N-terminal kina pekeemojamethyl badala ya mbili kama inauristatin Fyenyewe.