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Li-peptide le liprotheine li sebelisoa haholo ho phekola mafu a fapaneng, empa hangata li tlameha ho entoa 'me phello ea tsona ke ea nakoana.Mefokolo ena ea meaho ea matsoalloa e ka felisoa ka thuso ea boenjiniere ba limolek'hule, empa ona ke mosebetsi o boima.Mekhoa ea boenjiniere ea limolek'hule, eo qalong e neng e sebelisoa ho insulin, 'me hona joale e sebelisoa ka katleho ho li-biopharmaceuticals tse' maloa, e hloka hore ho ntšuoa li-peptide le liprotheine tse tsoang ho mafura a acid.Litšobotsi tse ikhethileng le sebaka sa li-acid tse kentsoeng li ka fana ka mekhoa e fapaneng ea ho lelefatsa.Ho phaella moo, theknoloji ena e ka fana ka nako e telele ea halofo ea bophelo ka mor'a tsamaiso ea molomo ea lithethefatsi tsa peptide, e ka fetola kabo ea li-peptide, 'me e ka ba le monyetla oa ho lebisa tlhokomelo ea lisele.Ka polokeho ea tlhaho ea li-acid tse mafura le thepa ea lik'hemik'hale e hlalositsoeng hantle, theknoloji ena e fana ka mokhoa o fapaneng oa ho sibolla lithethefatsi tsa peptide le protheine.
Litheko tsohle ke nete.VAT e tla eketsoa hamorao ha o lefa.Lipalo tsa lekhetho li tla etsoa ha u lefa.
Muttenthaler, M., King, GF, Adams, DJ & Alewood, PF Mekhoa ea ho sibolla lithethefatsi tsa peptide. Muttenthaler, M., King, GF, Adams, DJ & Alewood, PF Mekhoa ea ho sibolla lithethefatsi tsa peptide.Muttenthaler, M., King, GF, Adams, DJ le Alevud, PF Mekhoa ea ho sibolla lithethefatsi tsa peptide. Muttenthaler, M., King, GF, Adams, DJ & Alewood, PF 多肽药物发现的趋势. Muttenthaler, M., King, GF, Adams, DJ & Alewood, PFMuttenthaler, M., King, GF, Adams, DJ le Alevud, PF Mekhoa ea ho sibolla lithethefatsi tsa peptide.Naha Pulo ea moruti oa lithethefatsi.20, 309–325 (2021).Tlhahlobo ena e shebana le likarolo tsa hajoale le tsa nako e tlang tsa ho sibolloa ha lithethefatsi tsa peptide.
Müller, TD, Blüher, M., Tschöp, MH & DiMarchi, RD Ho sibolla lithethefatsi tse khahlanong le botenya: tsoelo-pele le mathata. Müller, TD, Blüher, M., Tschöp, MH & DiMarchi, RD Ho sibolla lithethefatsi tse khahlanong le botenya: tsoelo-pele le mathata.Müller, TD, Blucher, M., Chop, MH le DiMarchi, RD Ho sibolla lithethefatsi tse khahlanong le botenya: tsoelo-pele le mathata. Müller, TD, Blüher, M., Tschöp, MH & DiMarchi, RD 抗肥胖药物发现：进展和挑战。 Müller, TD, Blüher, M., Tschöp, MH & DiMarchi, RDMüller, TD, Blucher, M., Chop, MH le DiMarchi, RD Ho sibolla lithethefatsi tse khahlanong le botenya: tsoelo-pele le mathata.Naha Pulo ea moruti oa lithethefatsi.21, 201–223 (2022).Tlhahlobo ena e fana ka temohisiso ea mathata a botenya, haholo-holo likhopolo tse ncha tse thehiloeng ho li-peptide.
Strohl, WR Fusion protheine ho lelefatsa halofo ea bophelo ba biologics e le leano le molemohali la biologics.Biopharmaceutics 29, 215-239 (2015).
Evans, M. et al.Ho khomarela le ho phehella ha lithethefatsi tsa antidiabetic le ho kopana le liphello tsa kliniki le tsa moruo ho bakuli ba nang le lefu la tsoekere la mofuta oa 2: tlhahlobo e hlophisitsoeng ea lingoliloeng.botenya ba lefu la tsoekere.metabolism.24, 377–390 (2022).
Polonsky, WH, Fisher, L., Hessler, D., Bruhn, D. & Best, JH Maikutlo a mokuli ka meriana ea hang ka beke ea lefu la tsoekere. Polonsky, WH, Fisher, L., Hessler, D., Bruhn, D. & Best, JH Maikutlo a mokuli ka meriana ea hang ka beke ea lefu la tsoekere.Polonsky WH, Fisher L., Hessler D., Brune D., le Best JH Pono ea mokuli mabapi le meriana ea lefu la tsoekere hang ka beke. Polonsky, WH, Fisher, L., Hessler, D., Bruhn, D. & Best, JH 患者对每周一次的糖尿病药物的看法. Polonsky, WH, Fisher, L., Hessler, D., Bruhn, D. & Best, JHPolonsky WH, Fisher L., Hessler D., Brune D., le Mokuli ea Molemo ka ho Fetisisa oa JH oa maikutlo a meriana ea lefu la tsoekere hang ka beke.botenya ba lefu la tsoekere.metabolism.13, 144-149 (2011).
Hashimoto, M., Takada, K., Kiso, Y. & Muranishi, S. Synthesis ea palmitoyl derivatives ea insulin le mesebetsi ea bona ea likokoana-hloko. Hashimoto, M., Takada, K., Kiso, Y. & Muranishi, S. Synthesis ea palmitoyl derivatives ea insulin le mesebetsi ea bona ea likokoana-hloko.Hashimoto M., Takada K., Kiso Y. le Muranishi S. Synthesis of palmitoyl derivatives of insulin and their biological activity. Hashimoto, M., Takada, K., Kiso, Y. & Muranishi, S. 胰岛素棕榈酰衍生物的合成及其生物活性。 Hashimoto, M., Takada, K., Kiso, Y. & Muranishi, S. Synthesis le biological activity of insulin palmitoyl derivatives.Hashimoto M., Takada K., Kiso Y. le Muranishi S. Synthesis le biological activity of insulin palmitoyl derivatives.letamo la meriana 6, 171–176 (1989).
Kurtzhals, P. et al.Albumin e tlamang ho insulin ea mafura a acid-acylated: sebopeho sa litšebelisano tsa protheine ea ligand le khokahano lipakeng tsa kamano e tlamang le nako ea ts'ebetso ea insulin ka har'a vivo.biochem.J. 312, 725–731 (1995).Mosebetsi ona ke oa pele oa ho bontša keketseho ea halofo ea bophelo ka lebaka la ho tlama ha albumin ho li-peptide tse tsoang ho mafura a acids.
Mejuch, T. & Waldmann, H. Synthesis ea liprotheine tse nang le lipidated. Mejuch, T. & Waldmann, H. Synthesis ea liprotheine tse nang le lipidated.Meyukh, T. le Waldmann, H. Synthesis ea liprotheine tse nang le lipidated. Mejuch, T. & Waldmann, H. 脂化蛋白质的合成. Mecha, T.& Waldmann, H.Meyukh, T. le Waldmann, H. Synthesis ea liprotheine tse nang le lipidated.Bioconjugate.Lik'hemik'hale.27, 1771-1783 (2016).
Chen, B., Sun, Y., Niu, J., Jarugumilli, GK & Wu, X. Protein lipidation ka pontšo ea lisele le maloetse: ts'ebetso, taolo, le menyetla ea phekolo. Chen, B., Sun, Y., Niu, J., Jarugumilli, GK & Wu, X. Protein lipidation ka pontšo ea lisele le maloetse: ts'ebetso, taolo, le menyetla ea phekolo.Chen B., Sun Y., Niu J., Jarugumilli GK le Wu X. Protein lipidation ka pontšo ea lisele le maloetse: ts'ebetso, taolo, le bokhoni ba phekolo. Chen, B., Sun, Y., Niu, J., Jarugumilli, GK & Wu, X. 细胞信号和疾病中的蛋白质脂化：功能、调节和治疗机会。 Chen, B., Sun, Y., Niu, J., Jarugumilli, GK & Wu, X. Protein脂化 ka pontšo ea lisele le maloetse: ts'ebetso, taolo le menyetla ea phekolo.Chen B., Sun Y., Niu J., Jarugumilli GK le Wu X. Protein lipidation ka pontšo ea lisele le maloetse: ts'ebetso, taolo, le bokhoni ba phekolo.cytochemistry.baeloji 25, 817-831 (2018).
Richter, WF, Bhansali, SG & Morris, ME Mechanistic determinants ea biotherapeutics monya ka mor'a tsamaiso ea SC. Richter, WF, Bhansali, SG & Morris, ME Mechanistic determinants ea biotherapeutics monya ka mor'a tsamaiso ea SC.Richter, VF, Bhansali, SG le Morris, ME Mechanisms e khethollang ho kenngoa ha li-biotherapeutic agents ka mor'a tsamaiso ea subcutaneous. Richter, WF, Bhansali, SG & Morris, ME SC 给药后生物治疗药物吸收的机制决定因素. Richter, WF, Bhansali, SG & Morris, ME SC Richter, WF, Bhansali, SG & Morris, ME SC Механистические детерминанты абсорбции биотерапевтических препаратов после введения. Richter, WF, Bhansali, SG & Morris, ME SC Mechanistic determinants ea ho monya meriana ea biotherapeutic ka mor'a tsamaiso.AAPS J. 14, 559–570 (2012).
Gradel, AKJ le ba bang.Lintlha tse amang ho monya ha insulin ka subcutaneous: litlamorao tsa ho fetoha.J. Lefu la tsoekere Res.2018, 1205121 (2018).
Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Diffusion le polymerization li etsa qeto ea ho kenngoa ha insulin ho tloha ho subcutaneous tissue ho bakuli ba lefu la tsoekere. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Diffusion le polymerization li etsa qeto ea ho kenngoa ha insulin ho tloha ho subcutaneous tissue ho bakuli ba lefu la tsoekere. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Диффузия, L. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Diffusion le polymerization li etsa qeto ea ho kenngoa ha insulin ho tloha ho subcutaneous tissue ho bakuli ba lefu la tsoekere. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. 扩散和聚合决定了糖尿病患者皮下组织对胰岛组织对胰岛純的散。 Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Диффузия и агрегация определяют абсорбцию инсулина подкожной тканью песни. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Diffusion le aggregation li etsa qeto ea ho kenngoa ha subcutaneous insulin ho bakuli ba lefu la tsoekere.scanning.J. Klin.laboratori.tsetela.45, 685–690 (1985).
Mosekilde, E., Jensen, KS, Binder, C., Pramming, S. & Thorsteinsson, B. Modelling absorption kinetics of subcutaneous injected soluble insulin. Mosekilde, E., Jensen, KS, Binder, C., Pramming, S. & Thorsteinsson, B. Modelling absorption kinetics of subcutaneous injected soluble insulin.Mosekilde E, Jensen KS, Binder S, Pramming S, le Thorsteinsson B. Ho etsa mohlala oa kinetics ea ho monya ha subcutaneous soluble insulin. Mosekilde, E., Jensen, KS, Binder, C., Pramming, S. & Thorsteinsson, B. 模拟皮下注射可溶性胰岛素的吸收动力学。 Mosekilde, E., Jensen, KS, Binder, C., Pramming, S. & Thorsteinsson, B.Mosekilde E, Jensen KS, Binder S, Pramming S, le Thorsteinsson B. Ho etsa mohlala oa kinetics ea ho monya ha insulin e qhibilihang ka tlas'a letlalo.J. Pharmacokinetics.biopharmacy.17, 67–87 (1989).
Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III Saese ea molek'hule e fetola pharmacokinetics, biodistribution, le renal deposition ea phano ea lithethefatsi biopolymer elastin-like polypeptide. Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III Saese ea molek'hule e fetola pharmacokinetics, biodistribution, le renal deposition ea phano ea lithethefatsi biopolymer elastin-like polypeptide. Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III авки лекарственного средства. Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III Boholo ba molek'hule bo fetola pharmacokinetics, biodistribution, le renal deposition ea biopolymeric elastin-like polypeptide bakeng sa ho fana ka lithethefatsi. Kuna, M., Mahdi, F. Chade, AR & Bidwell, GL III脏沉积. Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III Molecule 大小名行电影送送biological polymer elastic protein sampleKuna, M., Mahdi, F., Chad, AR le Bidwell, GL III.Pharmacokinetics, biodistribution le renal deposition ea biopolymeric elastin-like polypeptides e fetolang boholo ba molek'hule.saense Tlaleho 8, 7923 (2018).
Harris, JM, Martin, NE & Modi, M. Pegylation: mokhoa o mocha oa ho fetola pharmacokinetics. Harris, JM, Martin, NE & Modi, M. Pegylation: mokhoa o mocha oa ho fetola pharmacokinetics. Harris, JM, Martin, NE & Modi, M. Пегилирование: новый процесс модификации фармакокинетики. Harris, JM, Martin, NE & Modi, M. Pegylation: mokhoa o mocha oa ho fetola pharmacokinetics. Harris, JM, Martin, NE & Modi, M. 聚乙二醇化：一种改变药代动力学的新方法。 Harris, JM, Martin, NE & Modi, M. 聚乙二感化: mokhoa o mocha oa ho fetola meriana. Harris, JM, Martin, NE & Modi, M. Пегилирование: новый подход к изменению фармакокинетики. Harris, JM, Martin, NE & Modi, M. Pegylation: mokhoa o mocha oa ho fetola pharmacokinetics.tleleniki.Pharmacokinetics.40, 539–551 (2001).
Elmerer, M. et al.Tekanyo ea albin ea interstitial ka har'a mesifa ea masapo a motho le lisele tsa adipose ka ho phalla ha microperfusion.Ee.J. Physiology.endocrine.metabolism.278, E352-E356 (2000).
Nelson, J. le al.Nako e telele ea halofo ea bophelo ea albumin ho batho e hloka C-terminus e sa fetoheng.buisana.baeloji.3, 181 (2020).
Chowdhury, K. et al.Fc receptor (FcRn) bakeng sa IgG e amanang le "histocompatibility complex" e kholo e kopanya albumin le ho lelefatsa bophelo ba eona.J. Exp.moriana.197, 315–322 (2003).
Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES Exocytosis ea IgG e le lipakeng tsa receptor, FcRn: tlhahlobo boemong ba molek'hule e le 'ngoe. Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES Exocytosis ea IgG e le lipakeng tsa receptor, FcRn: tlhahlobo boemong ba molek'hule e le 'ngoe. Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES Экзоцитоз IgG, опосредованный рецептором FcRn: анализ на уровне одной молекулы. Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES FcRn receptor-mediated IgG exocytosis: tlhahlobo ea molek'hule e le 'ngoe. Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES 受体介导的IgG 胞吐作用，FcRn：单分子水平的分析。 Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, Экзоцитоз IgG, опосредованный рецептором ES, FcRn: анализ на уровне одной молекулы. Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES receptor-mediated IgG exocytosis, FcRn: tlhahlobo e le 'ngoe ea molek'hule.tshebetso.Sekolo sa Sechaba sa Saense.saense.US 101, 11076 (2004).
Eena, XM & Carter, DC Atomic sebopeho le k'hemistri ea serum ea batho albumin. Eena, XM & Carter, DC Atomic sebopeho le k'hemistri ea serum ea batho albumin.On, XM le Carter, DC Atomic sebopeho le k'hemistri ea serum ea batho albumin. He, XM & Carter, DC 人血清白蛋白的原子结构和化学. Eena, XM & Carter, DC.On, XM le Carter, DC Atomic sebopeho le k'hemistri ea serum ea batho albumin.Tlhaho 358, 209–215 (1992).
Curry, S., Mandelkow, H., Brick, P. & Franks, N. Sebopeho sa Crystal sa albumin ea serum ea motho e kopantsoeng le mafura a acid e senola ho ajoa ha libaka tse tlamang. Curry, S., Mandelkow, H., Brick, P. & Franks, N. Sebopeho sa Crystal sa albumin ea serum ea motho e kopantsoeng le mafura a acid e senola ho ajoa ha libaka tse tlamang.Curry S., Mandelkow H., Brick P. le Franks N. Sebopeho sa kristale sa albumin ea serum ea batho e rarahaneng e nang le mafura a mafura e bontša kabo ea asymmetric ea libaka tse tlamang. Curry, S., Mandelkow, H., Brick, P. & Franks, N. Curry, S., Mandelkow, H., Brick, P. & Franks, N. Sebopeho sa kristale sa serum ea motho e tšoeu ea protheine e nang le mafura a acid e senola kabo ea asymmetric ea libaka tse tlamang.Curry S., Mandelkow H., Brick P. le Franks N. Sebopeho sa kristale sa albumin ea serum ea batho e rarahaneng e nang le mafura a acid e bonts'a kabo ea asymmetric ea libaka tse tlamang.Nat.sebopeho.baeloji 5, 827–835 (1998).Pampiri ena e fana ka motheo oa sebopeho sa ho tlama ha mafura acid ho serum albumin.
Irby, D., Du, C. & Li, F. Lipid-drug conjugate bakeng sa ho matlafatsa phano ea lithethefatsi. Irby, D., Du, C. & Li, F. Lipid-drug conjugate bakeng sa ho matlafatsa phano ea lithethefatsi.Irby, D., Du, K. le Li, F. Lipid-drug conjugates bakeng sa phano e ntlafetseng ea lithethefatsi. Irby, D., Du, C. & Li, F. Lipid-drug conjugate bakeng sa ho ntlafatsa phano ea lithethefatsi. Irby, D., Du, C. & Li, F. Lipid-drug conjugate bakeng sa ho ntlafatsa phano ea lithethefatsi.Irby, D., Du, K. le Li, F. Lipid-drug conjugate bakeng sa phano e ntlafetseng ea lithethefatsi.Biochemistry 14, 1325-1338 (2017).
Torchilin VP Khatelo-pele ea morao-rao lefapheng la liposomes e le bajari ba lithethefatsi.Naha Pulo ea moruti oa lithethefatsi.4, 145-160 (2005).
Bhat, M., Jatyan, R., Mittal, A., Mahato, RI & Chitkara, D. Menyetla le mathata a fatty acid conjugated therapeutics. Bhat, M., Jatyan, R., Mittal, A., Mahato, RI & Chitkara, D. Menyetla le mathata a fatty acid conjugated therapeutics.Bhat, M., Jatyan, R., Mittal, A., Mahato, RI le Chitkara, D. Menyetla le mathata a fatty acid conjugated therapeutics. Bhat, M., Jatyan, R., Mittal, A., Mahato, RI & Chitkara, D. 脂肪酸共轭疗法的机遇和挑战. Bhat, M., Jatyan, R., Mittal, A., Mahato, RI & Chitkara, D. Fatty acid 共续电影的机遇和challenge.Bhat M., Jatyan R., Mittal A., Mahato RI le Chitkara D. Menyetla le mathata a mafura a acid conjugation therapy.Lik'hemik'hale.fisiks Lipids 236, 105053 (2021).
Smith, R. & Tanford, C. Hydrophobicity ea ketane e telele ea n-alkyl carboxylic acid, ha e lekanngoa ka ho aroloa ha bona pakeng tsa heptane le tharollo ea metsi. Smith, R. & Tanford, C. Hydrophobicity ea ketane e telele ea n-alkyl carboxylic acid, ha e lekanngoa ka ho aroloa ha bona pakeng tsa heptane le tharollo ea metsi.Smith, R. le Tanford, K. Hydrophobicity of long-chain n-alkylcarboxylic acids e lekantsoeng ka kabo ea bona pakeng tsa heptane le tharollo ea metsi. Smith, R. & Tanford, C. Smith, R. & Tanford, C. The hydrophobicity of 长链正alkylcarboxylate, e lekantsoeng ka kabo ea bona pakeng tsa hydrogen peroxide le tharollo ea metsi.Smith, R. le Tanford, K. Hydrophobicity of long-chain n-alkylcarboxylic acids e lekantsoeng ka kabo ea bona pakeng tsa heptane le tharollo ea metsi.tshebetso.Sekolo sa Sechaba sa Mahlale.saense US 70, 289 (1973).
Liu, J. et al.Ho sibolloa ha semaglutide hanngoe ka beke ea glucagon-like peptide-1 (GLP-1).J. Meriana.Lik'hemik'hale.58, 7370-7380 (2015).Mosebetsi ona o bontša ka lekhetlo la pele monyetla oa ho sebelisa mekhoa ea ho ntša mafura a acid hang ka beke.
Østergaard, S. et al.Phello ea PYY3-36 ea motho ea dibasic fatty acylation ho mini-pig Y2 receptor mosebetsi le halofo ea bophelo.saense.Tlaleho 11, 21179 (2021).Sengoliloeng sena se bonts'a bohlokoa ba boemo ba acid e mafura, sehokelo le botsitso ba mokokotlo ho nts'etsopele ea li-analogue tsa PYY tse telele tsa halofo ea bophelo.
Ensenat-Vaser, R. et al.Ho kenella ha li-peptide tsa myristoylated ho pholletsa le lera la sele ho ile ha bonoa ka kotloloho ho sebelisoa microscopy ea confocal fluorescence.IUBMB Life 54, 33–36 (2002).
Nelson, AR, Borland, L., Allbritton, NL & Sims, CE Myristoyl e tsamaisang li-peptide ho kena liseleng tse phelang. Nelson, AR, Borland, L., Allbritton, NL & Sims, CE Myristoyl e tsamaisang li-peptide ho kena liseleng tse phelang.Nelson AR, Borland L, Allbritton NL.le Sims SE Lipalangoang tsa Peptide liseleng tse phelang li thehiloe ho myristoyl. Nelson, AR, Borland, L., Allbritton, NL & Sims, CE 基于肉豆蔻酰的肽转运到活细胞中. Nelson, AR, Borland, L., Allbritton, NL & Sims, CE.Nelson, AR, Borland, L., Albritton, NL.le Sims, KE Lipalangoang tsa li-peptide tse thehiloeng ho myristoyl ho kena liseleng tse phelang.Biochemistry 46, 14771-14781 (2007).
Kabanov, AV, Levashov, AV & Alakhov, VY Lipid phetoho ea liprotheine le lipalangoang tsa tsona. Kabanov, AV, Levashov, AV & Alakhov, VY Lipid phetoho ea liprotheine le lipalangoang tsa tsona.Kabanov AV, Levashov AV, Alakhov V.Yu.Phetoho ea lipid ea liprotheine le ho tsamaisa membrane ea tsona. Kabanov, AV, Levashov, AV & Alakhov, VY 蛋白质的脂质修饰及其膜转运。 Kabanov, AV, Levashov, AV & Alakhov, VYKabanov AV, Levashov AV, Alakhov, Lipid phetoho ea liprotheine tsa VY le lipalangoang tsa tsona.boenjiniere ba protheine.Dec. Searl.3, 39–42 (1989).
Gao, X., Mazière, AD, Beard, R., Klumperman, J. & Hannoush, RN Fatty acylation e ntlafatsa ho kenngoa ha cellular le ho ajoa ha cytosolic ea cystine-knot peptide. Gao, X., Mazière, AD, Beard, R., Klumperman, J. & Hannoush, RN Fatty acylation e ntlafatsa ho kenngoa ha cellular le ho ajoa ha cytosolic ea cystine-knot peptide.Gao, X., Mazier, AD, Byrd, R., Klumperman, J. le Hannoosh, RN Fatty acid acylation e ntlafatsa ho kenngoa ha cellular le ho ajoa ha cytosolic ea peptide e nang le cystine loop. Gao, X., Mazière, AD, Beard, R., Klumperman, J. & Hannoush, RN 脂肪酰化增强了胱氨酸结肽的细胞内化和胞质分布。 Gao, X., Mazière, AD, Beard, R., Klumperman, J. & Hannoush, RN.Gao, X., Mazier, AD, Byrd, R., Klumperman, J. le Hannoosh, RN Fatty acylation e ntlafatsa ho kenngoa ha cellular le ho ajoa ha cytoplasmic ea cystine peptide.iScience 24, 103220 (2021).
Baker, EM le ba bang.Phetoho ea ho lelefatsa bophelo ba halofo ea YY3-36 peptide bakeng sa ho kenella ka hare ho receptor ka kotloloho.Moore.moriana.16, 3665–3677 (2019).
Mäde, V., Bellmann-Sickert, K., Kaiser, A., Meiler, J. & Beck-Sickinger, AG Boemo le bolelele ba li-acid tse mafura li ama ka matla mokhoa oa ho khetha oa ho amohela li-analogues tsa pancreatic polypeptide. Mäde, V., Bellmann-Sickert, K., Kaiser, A., Meiler, J. & Beck-Sickinger, AG Boemo le bolelele ba li-acid tse mafura li ama ka matla mokhoa oa ho khetha oa ho amohela li-analogues tsa pancreatic polypeptide.E entsoe, W., Bellmann-Sickert, K., Kaiser, A., Mailer, J. le Beck-Sickinger, AG Boemo le bolelele ba li-acid tse mafura li susumetsa ka matla mokhoa oa ho khetha oa li-receptor tsa pancreatic polypeptide analog. Mäde, V., Bellmann-Sickert, K., Kaiser, A., Meiler, J. & Beck-Sickinger, AG 脂肪酸的位置. Mäde, V., Bellmann-Sickert, K., Kaiser, A., Meil er, J. & Beck-Sickert, AGE entsoe, W., Bellmann-Sickert, K., Kaiser, A., Mailer, J. le Beck-Sickinger, AG Boemo le bolelele ba li-acid tse mafura li susumetsa ka matla mokhoa oa ho khetha oa li-receptor tsa pancreatic analog polypeptide.HimMedChem 9, 2463–2474 (2014).
Aleksopoulou, F. et al.lipid metabolite PrRP31 ke GPR10 le NPFF2 receptor agonist ea nako e telele e nang le litlamorao tse matla tsa ho theola boima ba 'mele.saense.Tlaleho ea 12, 1696 (2022).Thuto ena ea mekhoa e totobatsa phapang pakeng tsa liketane tsa mahlakoreng a mono- le diacid.
Poulsen, K. et al.Tsoelo-pele e utloahalang ea li-agonists tse tsitsitseng tsa Y2 receptor peptide PYY3-36.moriana.tanka ea polokelo.38, 1369–1385 (2021).
Conde-Frieboes, K. et al.Ho tsebahatsa le ho khetholla li-analogues tsa in vitro le in vivo tsa melanocortin 4 receptor (MC4-R) ea alpha-melanocyte-stimulating hormone (alpha-MSH) ea nako e telele le e khethiloeng.J. Meriana.Lik'hemik'hale.55, 1969-1977 (2012).
Ramirez-Andersen, HS et al.Li-analogues tsa nako e telele tsa kholo ea motho li tlamahanngoa le albin e sa kopaneng.Bioconjugate.Lik'hemik'hale.29, 3129-3143 (2018).
Madsen, K. et al.Kamano ea sebopeho le ts'ebetso le ho atolosoa ha lintho tse tsoang ho glucagon-joaloka peptide-1 ea nako e telele: bohlokoa ba bolelele ba asiti e mafura, polarity, le molumo.J. Meriana.Lik'hemik'hale.50, 6126-6132 (2007).
Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Li-derivatives tsa GLP-1 tse peli tse nang le acylated. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Li-derivatives tsa GLP-1 tse peli tse nang le acylated. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Дважды ацилированные производные GLP-1. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Li-acylated derivatives tsa GLP-1 ka makhetlo a mabeli. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. 双酰化GLP-1 衍生物. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. 双酰化GLP-1 衍生物. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Диацилированные производные GLP-1. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Diacylated derivatives ea GLP-1.US Patent WO2012/140117 (2012).
Mocha, P.-Yu.Ema.Li-analogues tse matla, tsa nako e telele tsa GLP-1 tse etselitsoeng ho fana ka transdermal ho ipapisitse le microstructure.tshebetso.Sekolo sa Sechaba sa Saense.saense.US 113, 4140-4145 (2016).
Royalty, JE, Konradsen, G., Eskerod, O., Wulff, BS & Hansen, BS Patlisiso ea tšireletseho, mamello, pharmacokinetics, le pharmacodynamics ea tekanyo e le 'ngoe le e mengata ea nako e telele ea α-MSH analog ea boima bo feteletseng le botenya. bafo. Royalty, JE, Konradsen, G., Eskerod, O., Wulff, BS & Hansen, BS Patlisiso ea tšireletseho, mamello, pharmacokinetics, le pharmacodynamics ea tekanyo e le 'ngoe le e mengata ea nako e telele ea α-MSH analog ea boima bo feteletseng le botenya. bafo.Royalty, JE, Konradsen, G., Eskerod, O., Wolf, BS le Hansen, BS Safety, tolerability, pharmacokinetics, le pharmacodynamics thuto ea tekanyo e le 'ngoe le e mengata ea nako e telele ea α-MSG analog litabeng tse phetseng hantle tse feteletseng le tse nonneng.版税, JE, Konradsen, G., Eskerod, O., Wulff, BS & Hansen, BS 单剂量和多剂量长效α-MSH受性、药代动力学和药效学研科目。版税, JE, Konradsen, G., Eskerod, O., Wulff, BS & Hansen, BS Tekanyetso e le 'ngoe le phello e telele ea litekanyetso tse ngata α-MSH 全健康超重和肥胖可以中可以而受受药效学研究科目。Royalty, JE, Konradsen, G., Eskerod, O., Wolf, BS le Hansen, BS Safety, tolerability, pharmacokinetics ea litekanyetso tse le 'ngoe le tse ngata tsa li-analogue tsa alpha-MSG tsa nako e telele ho batho ba nang le boima bo feteletseng le ba batenya.Kinetics le pharmacodynamics.J. Clin.Pharmacodynamics.54, 394–404 (2014).
Lau, J., F., Kruse, T., Linderoth, L. & Thøgersen, H. Novel glucagon analogues. Lau, J., F., Kruse, T., Linderoth, L. & Thøgersen, H. Novel glucagon analogues.Lau, J., F., Kruse, T., Linderoth, L. le Togersen, H. Li-analogue tse ncha tsa glucagon. Lau, J., F., Kruse, T., Linderoth, L. & Thøgersen, H. 新型胰高血糖素类似物。 Lau, J., F., Kruse, T., Linderoth, L. & Thøgersen, H.Lau, J., F., Cruz, T., Linderoth, L. le Togersen, H. Li-analogue tse ncha tsa glucagon.US Patent WO2011/117416 A1 (2011).
Ward, BP et al.Lipidation tsa li-peptide li tsitsisa meaho ho ntlafatsa ts'ebetso ea bioloji.Moore.metabolism.2, 468–479 (2013).Mosebetsi ona o bonts'a karolo ea liketane tsa mahlakoreng a mafura a acid ho fumana botsitso ba sebopeho le ho tlama li-receptor tsa lithethefatsi tsa peptide.
Koskun T. et al.LY3298176, buka e ncha ea GIP le GLP-1 receptor agonist bakeng sa kalafo ea lefu la tsoekere la mofuta oa 2: ho tloha ho sibolloa ho isa bopaking ba kliniki ba mohopolo.Moore.metabolism.18, 3-14 (2018).Pampiri ena e fana ka moralo oa co-agonist ea pele e entsoeng ka mafura a GLP-1/GIP bakeng sa tsamaiso ea hang ka beke tleliniking.
Kjeldsen, TB et al.Boenjineri ba limolek'hule tsa insulin ea icodec, e leng analoge ea pele ea acylated ea insulin ea hang ka beke ho batho.J. Meriana.Lik'hemik'hale.64, 8942–8950 (2021).Pampiri ena e fana ka tlhahiso ea pele ea insulin e tsoang ho mafura a acid e sebelisoang hang ka beke.
van Witteloostein, SB et al.Neoglycolipids bakeng sa li-peptide tse sebetsang nako e telele: li-analogue tse ikopanyang tsa glucagon-like peptide 1 e nang le thepa e tlamang albin le matla a phahameng a vivo.Moore.moriana.14, 193-205 (2017).
Zorzi, A., Middendorp, SJ, Wilbs, J., Deyle, K. & Heinis, C. Acylated heptapeptide e tlama albumin ka kamano e phahameng le ts'ebeliso ha tag e fana ka li-peptide tsa nako e telele. Zorzi, A., Middendorp, SJ, Wilbs, J., Deyle, K. & Heinis, C. Acylated heptapeptide e tlama albumin ka kamano e phahameng le ts'ebeliso ha tag e fana ka li-peptide tsa nako e telele.Zorzi, A., Middendorp, SJ, Wilbs, J., Dale, K. le Haynes, S. Acylated heptapeptide e kopanya albumin ka kamano e phahameng, 'me tšebeliso ea eona e le letšoao e fana ka peptide ea nako e telele. Zorzi, A., Middendorp, SJ, Wilbs, J., Deyle, K. & Heinis, C. Zorzi, A., Middendorp, SJ, Wilbs, J., Deyle, K. & Heinis, C. 鎄化七peptide以高亲和力设计白白约筒，使用于设计手机。Zorzi, A., Middendorp, SJ, Wilbs, J., Dale, K. le Haynes, S. Acylated heptapeptides e kopanya albumin ka kamano e phahameng mme e sebetsa e le li-labels bakeng sa ho fana ka peptide ea nako e telele.Nat.buisana 8, 16092 (2017).
Nako ea poso: Sep-08-2022
