Sehlahisoa: Linaclotide
Synonym: Linaclotide Acetate
Nomoro ea CAS: 851199-59-2
Foromo ea molek'hule: C59H79N15O21S6
Boima ba 'mele: 1526.8
Ponahalo: Phofo e tšoeu
Bohloeki: >98%
Tatelano: NH2-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH

Linaclotide ke maiketsetso, amino acid peptide e leshome le metso e mene le agonist ea intestinal guanylate cyclase type C (GC-C), e amanang ka sebopeho le lelapa la guanylin peptide, ka mesebetsi ea secretagogue, analgesic le laxative. Kamora ho tsamaisoa ka molomo, linaclotide e tlama le ho kenya tšebetsong li-receptor tsa GC-C tse sebakeng se khanyang sa epithelium ea mala. Sena se eketsa bongata ba intracellular cyclic guanosine monophosphate (cGMP), e tsoang ho guanosine triphosphate (GTP). cGMP e kenya tšebetsong cystic fibrosis transmembrane conductance regulator (CFTR) mme e hlohlelletsa secretion ea chloride le bicarbonate ka har'a lumen ea mala. Sena se khothalletsa ho tsoa ha sodium ka har'a lumen 'me ho fella ka ho eketseha ha mokelikeli oa mala. Sena se qetella se potlakisa phetisetso ea GI ka har'a mala, se ntlafatsa tsamaiso ea mala le ho imolla ho patoa. Maemo a eketsehileng a extracellular cGMP a ka boela a ba le phello ea antinociceptive, ka mokhoa o seng o ntse o sa tsejoe ka botlalo, o ka kenyelletsang ho feto-fetoha ha li-nociceptors tse fumanoang ho li-colon afferent pain fibers. Linaclotide e kenella hanyane ho tsoa pampitšaneng ea GI.