Linaclotide
Erayada furaha
- LinaclotideSaldhig
- qiimaha ugu jaban
- CAS # 851199-59-2
Faahfaahin Deg Deg ah
- Magaca Pro: Linaclotide
- CasNo: 851199-59-2
- Qaacidada molecular: C59H79N15O21S6
- Muuqaal: budo cad
- Codsiga: waxaa loo isticmaalaa daawaynta calool-istaagga
- DeliveryTime: shixnad degdeg ah
- Xidhmada: sida waafaqsan shuruudaha macmiilka
- Dekadda: Shenzhen
- Awood Wax-Soosaar: 1 Kiiloogram/Bishii
- daahirnimo: 98%
- Kaydinta: 2 ~ 8 ℃. laga ilaaliyo iftiinka
- Gaadiidka: hawada
- Xadka Tirada: 1 garaam
Sarraynta
Faahfaahin
Alaabta: Linaclotide
La mid ah: Linaclotide Acetate
CAS No.: 851199-59-2
Qaacidada molecular: C59H79N15O21S6
Miisaanka Molecular: 1526.8
Muuqaal: budo cad
daahirnimo:>98%
Taxanaha: NH2-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH
Linaclotide waa synthetic, afar iyo toban amino acid peptide iyo agonist of xiidmaha guanylate cyclase nooca C (GC-C), kaas oo qaab dhismeed la xidhiidha qoyska guanylin peptide, oo leh sirta, xanuunka xanuunka iyo hawlaha caloosha. Marka la maamulo afka, linaclotide waxay ku xidhan tahay oo ay hawlgelisaa soo-qabayaasha GC-C ee ku yaal dusha sare ee epithelium mindhicirka. Tani waxay kordhinaysaa fiirsashada guanosin monophosphate (cGMP), kaas oo ka yimid guanosine triphosphate (GTP). cGMP waxa ay kicisaa cystic fibrosis transmembrane conductance regulator (CFTR) waxayna kicisaa dheecaanka chloride iyo bicarbonate gudaha lumen mindhicirka. Tani waxay kor u qaadaysaa soodhiyamka soodhiyamka ee lumen waxayna keentaa korodhka dheecaanka xiidmaha. Tani waxay ugu dambeyntii dedejisaa socodka GI ee waxa ku jira mindhicirka, wanaajiso dhaqdhaqaaqa mindhicirka waxayna yaraynaysaa calool-istaagga. Kordhinta heerarka cGMP ee ka baxsan unugga ayaa sidoo kale laga yaabaa inay sameeyaan saameyn antinociceptive, iyada oo loo marayo habka aan weli si buuxda loo caddayn, kaas oo ku lug yeelan kara isbeddelka nociceptors ee laga helo fiilooyinka xanuunka afferent colonic. Linaclotide waxaa si yar looga nuugaa marinka GI.
