Muna Chivabvu 2022, Shenzhen JYMed Technology Co., Ltd. (inozonzi JYMed peptide) yakaendesa chikumbiro chekunyoreswa semaglutide API kuUS Food and Drug Administration (FDA) (DMF nhamba yekunyoresa: 036009), Yapfuura. kuongororwa kwekuvimbika, uye chimiro chazvino "A". JYMed peptide yave imwe yekutanga batch ye semaglutide API vagadziri muChina kupasa iyo US FDA wongororo.

Musi waKukadzi 16, 2023, webhusaiti yepamutemo yeDrug Evaluation Center yeState Drug Administration yakazivisa kuti semaglutide API [nhamba yekunyoresa: Y20230000037] yakanyoreswa uye yakaziviswa naHubei JXBio Co., Ltd., inotsigira JYMed peptide, yawana. zvakagamuchirwa. JYMed peptide yave imwe yevagadziri vekutanga zvinodhaka vane kushambadzira kwechigadzirwa ichi kwakagamuchirwa muChina.

About semaglutide
Semaglutide iGLP-1 receptor agonist yakagadzirwa naNovo Nordisk (Novo Nordisk). Mushonga unogona kuwedzera glucose metabolism nekukurudzira pancreatic β masero kuti abudise insulin, uye inhibisa kugadzirwa kweglucagon kubva pancreatic α masero kuderedza kutsanya uye postprandial shuga yeropa. Mukuwedzera, inoderedza kudya kwekudya nekuderedza kudya uye kunonoka kugaya mudumbu, izvo zvinopedzisira zvaderedza mafuta emuviri uye zvinobatsira mukurasikirwa.
1. Ruzivo rwekutanga
Kubva pakuona kwemaitiro, kana ichienzaniswa neliraglutide, shanduko huru ye semaglutide ndeyekuti maAEEA maviri akawedzerwa kudivi reketani re lysine, uye palmitic acid yakatsiviwa neoctadecanedioic acid. Alanine yakatsiviwa naAib, iyo yakawedzera zvikuru hafu yeupenyu hwemaglutide.

Mufananidzo Chimiro che semaglutide

2. Zviratidzo
1) Semaglutide inogona kuderedza njodzi yezviitiko zvemoyo kune varwere vane T2D.
2) Semaglutide inoderedza shuga yeropa nekukurudzira insulin secretion uye kuderedza glucagon secretion. Kana shuga yeropa yakakwira, insulin secretion inokurudzirwa uye glucagon secretion inodzivirirwa.
3) Novo Nordisk PIONEER kliniki yekuedza yakaratidza kuti oral administration ye semaglutide 1mg, 0.5mg ine nani hypoglycemic uye kuora kurasikirwa nemigumisiro pane Trulicity (dulaglutide) 1.5mg, 0.75mg.
3) Oral semaglutide ndiyo kadhi yehwamanda yeNovo Nordisk. Kutonga kwemuromo kamwe chete pazuva kunogona kubvisa kusagadzikana uye kushungurudzwa kwepfungwa kunokonzerwa nejekiseni, uye zviri nani pane liraglutide (jekiseni kamwe pasvondo). Iyo hypoglycemic uye uremu-kurasikirwa nemhedzisiro yemishonga yakawanda yakadai se, empagliflozin (SGLT-2) uye sitagliptin (DPP-4) inokwezva zvikuru kuvarwere nevarapi. Kuenzaniswa nekugadzirwa kwejekiseni, kuumbwa kwemuromo kuchavandudza zvakanyanya kuve nyore kwekiriniki yekushandisa semaglutide.

3. Pfupiso
Izvo chaizvo nekuda kwekuita kwayo kwakanakisa mu hypoglycemic, kuonda uremu, kuchengetedzwa uye zvemoyo mabhenefiti ayo semaglutide yave chiitiko-chikamu "nyeredzi itsva" ine yakakura musika tarisiro.