Derivatization yemafuta acids mukuwanikwa kwepeptide uye mapuroteni zvinodhaka

Ndatenda nekushanyira Nature.com.Shanduro yebrowser yauri kushandisa ine tsigiro yeCSS shoma.Kuti uwane ruzivo rwakanyanya, tinokurudzira kuti ushandise browser yakagadziridzwa (kana kudzima Compatibility Mode muInternet Explorer).Zvichakadaro, kuti tive nechokwadi chekuenderera mberi nerutsigiro, isu tinopa saiti pasina masitaera uye JavaScript.
Peptides uye mapuroteni anoshandiswa zvakanyanya kurapa zvirwere zvakasiyana-siyana, asi kazhinji anofanirwa kubaiwa uye maitiro avo ndeenguva pfupi.Izvi zvikanganiso zvezvivakwa zvekuzvarwa zvinogona kubviswa nerubatsiro rwema molecular engineering, asi iri ibasa rakaoma.Molecular engineering matekiniki, yakatanga kushandiswa kune insulin uye ikozvino yakabudirira kushandiswa kune akati wandei biopharmaceuticals, inoda kuburitswa kwepeptides uye mapuroteni kubva kumafuta acids.Iwo chaiwo maitiro uye nzvimbo yeakabatanidzwa mafuta acids anogona kupa akasiyana elongation maitiro.Pamusoro pezvo, tekinoroji iyi inogona kupa hafu yeupenyu hurefu mushure mekutonga nemuromo kwemishonga yepeptide, inogona kushandura kugoverwa kwepeptides, uye inogona kuve nekugona kwekunangwa kwematishu.Nekuchengetedzwa kwemukati kwemafuta acids uye yakanyatsotsanangurwa kemikari zvivakwa, iyi tekinoroji inopa nzira dzakasiyana-siyana dzekuwana peptide uye mapuroteni zvinodhaka.
Mitengo yese ndeye mambure.VAT inowedzerwa gare gare pakubuda.Maverengero emutero achaitwa panguva yekubhadhara.
Muttenthaler, M., King, GF, Adams, DJ & Alewood, PF Maitiro ekuwanikwa kwepeptide zvinodhaka. Muttenthaler, M., King, GF, Adams, DJ & Alewood, PF Maitiro ekuwanikwa kwepeptide zvinodhaka.Muttenthaler, M., King, GF, Adams, DJ naAlevud, PF Mafambiro ekuwanikwa kwezvinodhaka zvepeptide. Muttenthaler, M., King, GF, Adams, DJ & Alewood, PF 多肽药物发现的趋势. Muttenthaler, M., King, GF, Adams, DJ & Alewood, PFMuttenthaler, M., King, GF, Adams, DJ naAlevud, PF Mafambiro ekuwanikwa kwezvinodhaka zvepeptide.National Kuvhurwa kwemufundisi wezvinodhaka.20, 309–325 (2021).Ongororo iyi inotarisa pane zvazvino uye zveramangwana zvekutsvaga peptide mushonga.
Müller, TD, Blüher, M., Tschöp, MH & DiMarchi, RD Anti-obesity kuwanikwa kwezvinodhaka: kufambira mberi uye matambudziko. Müller, TD, Blüher, M., Tschöp, MH & DiMarchi, RD Anti-obesity kuwanikwa kwezvinodhaka: kufambira mberi uye matambudziko.Müller, TD, Blucher, M., Chop, MH uye DiMarchi, RD Anti-obesity kuwanikwa kwezvinodhaka: kufambira mberi nematambudziko. Müller, TD, Blüher, M., Tschöp, MH & DiMarchi, RD 抗肥胖药物发现：进展和挑战. Müller, TD, Blüher, M., Tschöp, MH & DiMarchi, RDMüller, TD, Blucher, M., Chop, MH uye DiMarchi, RD Anti-obesity kuwanikwa kwezvinodhaka: kufambira mberi nematambudziko.National Kuvhurwa kwemufundisi wezvinodhaka.21, 201–223 (2022).Ongororo iyi inopa nzwisiso yezvinetso zvekufutisa, kunyanya mitsva mitsva yakavakirwa peptides.
Strohl, WR Fusion mapuroteni ekuwedzera hafu-yehupenyu hwe biologics seyakanakisa zano rebiologics.Biopharmaceutics 29, 215-239 ​​(2015).
Evans, M. nevamwe.Kuomerera uye kupfuurira kwemishonga yeAntidiabetic uye kushamwaridzana nemigumisiro yekliniki uye yehupfumi kune varwere vane chirwere cheshuga chechipiri: kuongorora kwakarongeka kwezvinyorwa.chirwere cheshuga kufutisa.metabolism.24, 377–390 (2022).
Polonsky, WH, Fisher, L., Hessler, D., Bruhn, D. & Best, JH Maonero evarwere pane kamwe-vhiki nevhiki mishonga yechirwere cheshuga. Polonsky, WH, Fisher, L., Hessler, D., Bruhn, D. & Best, JH Maonero evarwere pane kamwe-vhiki nevhiki mishonga yechirwere cheshuga.Polonsky WH, Fisher L., Hessler D., Brune D., uye Best JH Maonero emurwere pamishonga yechirwere cheshuga kamwe chete pavhiki. Polonsky, WH, Fisher, L., Hessler, D., Bruhn, D. & Zvakanakisisa, JH 患者对每周一次的糖尿病药物的看法. Polonsky, WH, Fisher, L., Hessler, D., Bruhn, D. & Best, JHPolonsky WH, Fisher L., Hessler D., Brune D., uye Best JH Murwere maonero emishonga yechirwere cheshuga kamwe chete pavhiki.chirwere cheshuga kufutisa.metabolism.13, 144–149 (2011).
Hashimoto, M., Takada, K., Kiso, Y. & Muranishi, S. Synthesis yepalmitoyl derivatives ye insulin uye mabasa avo ehupenyu. Hashimoto, M., Takada, K., Kiso, Y. & Muranishi, S. Synthesis yepalmitoyl derivatives ye insulin uye mabasa avo ehupenyu.Hashimoto M., Takada K., Kiso Y. uye Muranishi S. Synthesis of palmitoyl derivatives of insulin and their biological activity. Hashimoto, M., Takada, K., Kiso, Y. & Muranishi, S. 胰岛素棕榈酰衍生物的合成及其生物活性. Hashimoto, M., Takada, K., Kiso, Y. & Muranishi, S. Synthesis uye biological basa re insulin palmitoyl derivatives.Hashimoto M., Takada K., Kiso Y. uye Muranishi S. Synthesis uye biological basa re insulin palmitoyl derivatives.mushonga reservoir 6, 171–176 (1989).
Kurtzhals, P. et al.Albumin inosunga kune fatty acid-acylated insulini: maitiro e-ligand-protein interactions uye kuwirirana pakati pekubatanidza kushamwaridzana uye insulin chiito nguva mu vivo.biochem.J. 312, 725–731 (1995).Iri basa ndiro rekutanga kuratidza kuwedzera kwehafu yehupenyu nekuda kwekusungwa kwe albumin kune peptides yakabva kune mafuta acids.
Mejuch, T. & Waldmann, H. Synthesis yemapuroteni ane lipidated. Mejuch, T. & Waldmann, H. Synthesis yemapuroteni ane lipidated.Meyukh, T. uye Waldmann, H. Synthesis yemapuroteni ane lipidated. Mejuch, T. & Waldmann, H. 脂化蛋白质的合成. Mejuch, T.& Waldmann, H.Meyukh, T. uye Waldmann, H. Synthesis yemapuroteni ane lipidated.Bioconjugate.Chemical.27, 1771–1783 (2016).
Chen, B., Zuva, Y., Niu, J., Jarugumilli, GK & Wu, X. Protein lipidation mumasero echiratidzo uye zvirwere: basa, mutemo, uye mikana yekurapa. Chen, B., Zuva, Y., Niu, J., Jarugumilli, GK & Wu, X. Protein lipidation mumasero echiratidzo uye zvirwere: basa, mutemo, uye mikana yekurapa.Chen B., Sun Y., Niu J., Jarugumilli GK uye Wu X. Protein lipidation mumasero echiratidzo uye chirwere: basa, mutemo, uye simba rekurapa. Chen, B., Sun, Y., Niu, J., Jarugumilli, GK & Wu, X. 细胞信号和疾病中的蛋白质脂化：功能、调节和治疗机会。 Chen, B., Zuva, Y., Niu, J., Jarugumilli, GK & Wu, X. Protein脂化 muchiratidzo chemasero uye chirwere: basa, mutemo uye mikana yekurapa.Chen B., Sun Y., Niu J., Jarugumilli GK uye Wu X. Protein lipidation mumasero echiratidzo uye chirwere: basa, mutemo, uye simba rekurapa.cytochemistry.biology 25, 817-831 (2018).
Richter, WF, Bhansali, SG & Morris, ME Mechanistic determinants of biotherapeutics absorption inotevera SC administration. Richter, WF, Bhansali, SG & Morris, ME Mechanistic determinants of biotherapeutics absorption inotevera SC administration.Richter, VF, Bhansali, SG naMorris, ME Mechanisms anotarisisa kutorwa kwebiotherapeutic agents mushure mekutonga kwe subcutaneous. Richter, WF, Bhansali, SG & Morris, ME SC 给药后生物治疗药物吸收的机制决定因素. Richter, WF, Bhansali, SG & Morris, ME SC Richter, WF, Bhansali, SG & Morris, ME SC Механистические детерминанты абсорбции биотерапевтических препаратов после введения. Richter, WF, Bhansali, SG & Morris, ME SC Mechanistic zvirevo zvekutorwa kwemishonga yebiotherapeutic mushure mekutonga.AAPS J. 14, 559–570 (2012).
Gradel, AKJ nevamwe.Zvinhu zvinokanganisa subcutaneous insulin absorption: zvinokonzerwa nekusiyana.J. Diabetes Res.2018, 1205121 (2018).
Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Diffusion uye polymerization inosarudza insulini inotorwa kubva kune subcutaneous tissue muvarwere vane chirwere cheshuga. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Diffusion uye polymerization inosarudza insulini inotorwa kubva kune subcutaneous tissue muvarwere vane chirwere cheshuga. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Диффузия и полимеризация определяют абсорбцию инсулина из подкожной ткание пание песни. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Diffusion uye polymerization inogadzirisa insulini inotorwa kubva kune subcutaneous tissue muvarwere vane chirwere cheshuga. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. 扩散和聚合决定了糖尿病患者皮下组织对胰岛純的树。 Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Diffusion uye aggregation inosarudza subcutaneous insulin absorption muvarwere vane chirwere cheshuga.scanning.J. Klin.rabhoritari.invest.45, 685–690 (1985).
Mosekilde, E., Jensen, KS, Binder, C., Pramming, S. & Thorsteinsson, B. Modelling absorption kinetics ye subcutaneous injected soluble insulin. Mosekilde, E., Jensen, KS, Binder, C., Pramming, S. & Thorsteinsson, B. Modelling absorption kinetics ye subcutaneous injected soluble insulin.Mosekilde E, Jensen KS, Binder S, Pramming S, uye Thorsteinsson B. Modelling the absorption kinetics of subcutaneous soluble insulin. Mosekilde, E., Jensen, KS, Binder, C., Pramming, S. & Thorsteinsson, B. 模拟皮下注射可溶性胰岛素的吸收动力学。 Mosekilde, E., Jensen, KS, Binder, C., Pramming, S. & Thorsteinsson, B.Mosekilde E, Jensen KS, Binder S, Pramming S, uye Thorsteinsson B. Modelling the absorption kinetics of subcutaneously administered soluble insulin.J. Pharmacokinetics.biopharmacy.17, 67–87 (1989).
Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III Saizi yemamorekuru inogadziridza pharmacokinetics, biodistribution, uye renal deposition yezvinodhaka kuendesa biopolymer elastin-like polypeptide. Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III Saizi yemamorekuru inogadziridza pharmacokinetics, biodistribution, uye renal deposition yezvinodhaka kuendesa biopolymer elastin-like polypeptide. Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III авки лекарственного средства. Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III Saizi yemamorekuru inogadzirisa pharmacokinetics, biodistribution, uye renal deposition yebiopolymeric elastin-yakafanana polypeptide yekuendesa zvinodhaka. Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III, GL III脏沉积. Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III Molecule 大小名行电影送送biological polymer elastic protein sample 多如乐的药代报学学, biological kugoverwa pamwe cheteKuna, M., Mahdi, F., Chad, AR uye Bidwell, GL III.Pharmacokinetics, biodistribution uye renal deposition yebiopolymeric elastin-senge polypeptides inogadzirisa saizi yemorekuru.sainzi Report 8, 7923 (2018).
Harris, JM, Martin, NE & Modi, M. Pegylation: chirongwa chitsva chekugadzirisa pharmacokinetics. Harris, JM, Martin, NE & Modi, M. Pegylation: chirongwa chitsva chekugadzirisa pharmacokinetics. Harris, JM, Martin, NE & Modi, M. Пегилирование: новый процесс модификации фармакокинетики. Harris, JM, Martin, NE & Modi, M. Pegylation: chirongwa chitsva chekugadzirisa pharmacokinetics. Harris, JM, Martin, NE & Modi, M. 聚乙二醇化：一种改变药代动力学的新方法. Harris, JM, Martin, NE & Modi, M. 聚乙二感化: nzira itsva yekuchinja mushonga. Harris, JM, Martin, NE & Modi, M. Пегилирование: новый подход к изменению фармакокинетики. Harris, JM, Martin, NE & Modi, M. Pegylation: nzira itsva yekuchinja pharmacokinetics.kliniki.Pharmacokinetics.40, 539–551 (2001).
Elmerer, M. nevamwe.Kuyera kweinterstitial albumin mumhasuru yeskeletal yemunhu uye adipose tishu nekuvhurika kuyerera microperfusion.Ehe.J. Physiology.endocrine.metabolism.278, E352-E356 (2000).
Nelson, J. nevamwe.Iyo yakareba hafu yehupenyu hwealbumin muvanhu inoda C-terminus yakasimba.communication.biology.3, 181 (2020).
Chowdhury, K. et al.Iyo Fc receptor (FcRn) yeIgG yakabatana neyakakura histocompatibility complex inosunga albumin uye inorebesa hupenyu hwayo.J. Exp.mushonga.197, 315–322 (2003).
Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES Exocytosis yeIgG sezvainopindirana nemugamuchiri, FcRn: kuongororwa pane imwe-molecule level. Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES Exocytosis yeIgG sezvainopindirana nemugamuchiri, FcRn: kuongororwa pane imwe-molecule level. Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES Экзоцитоз IgG, опосредованный рецептором FcRn: анализ на уровне одной молекулы. Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES FcRn receptor-mediated IgG exocytosis: single-molecule analysis. Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES 受体介导的IgG 胞吐作用，FcRn：单分子水平的分析。 Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, Экзоцитоз IgG, опосредованный рецептором ES, FcRn: анализ на уровне одной молекулы. Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES receptor-mediated IgG exocytosis, FcRn: single molecule-level analysis.process.National Academy yeSainzi.sainzi.US 101, 11076 (2004).
Iye, XM & Carter, DC Atomic chimiro uye chemistry yemunhu serum albumin. Iye, XM & Carter, DC Atomic chimiro uye chemistry yemunhu serum albumin.Pa, XM uye Carter, DC Atomic chimiro uye chemistry yemunhu serum albumin. Iye, XM & Carter, DC 人血清白蛋白的原子结构和化学. Iye, XM & Carter, DC.Pa, XM uye Carter, DC Atomic chimiro uye chemistry yemunhu serum albumin.Zvisikwa 358, 209–215 (1992).
Curry, S., Mandelkow, H., Brick, P. & Franks, N. Crystal structure ye human serum albumin complexed with fatty acid inobudisa asymmetric kugoverwa kwemasayiti anosunga. Curry, S., Mandelkow, H., Brick, P. & Franks, N. Crystal structure ye human serum albumin complexed with fatty acid inobudisa asymmetric kugoverwa kwemasayiti anosunga.Curry S., Mandelkow H., Brick P. naFranks N. The crystal structure ye human serum albumin in complex with a fatty acid inoratidza asymmetric kugoverwa kwemasayiti anosunga. Curry, S., Mandelkow, H., Brick, P. & Franks, N. 与脂肪酸复合的人血清白蛋白的晶体结构揭示了结合位点的不 Curry, S., Mandelkow, H., Brick, P. & Franks, N. The crystal structure yemunhu serum white protein complex ine fatty acids inoratidza kugoverwa kweasymmetric yemasayiti anosunga.Curry S., Mandelkow H., Brick P. naFranks N. The crystal structure ye human serum albumin in complex with fatty acids inoratidza kuparadzirwa kweasymmetric yemasayiti anosunga.Nat.chimiro.biology 5, 827–835 (1998).Iri bepa rinopa hwaro hwemaitiro ekusunga kwemafuta acids kune serum albumin.
Irby, D., Du, C. & Li, F. Lipid-drug conjugate yekusimudzira kuendeswa kwezvinodhaka. Irby, D., Du, C. & Li, F. Lipid-drug conjugate yekusimudzira kuendeswa kwezvinodhaka.Irby, D., Du, K. uye Li, F. Lipid-drug conjugates kuitira kuwedzerwa kutengeswa kwezvinodhaka. Irby, D., Du, C. & Li, F. Lipid-drug conjugate yekusimudzira kuendeswa kwezvinodhaka. Irby, D., Du, C. & Li, F. Lipid-drug conjugate yekusimudzira kuendeswa kwezvinodhaka.Irby, D., Du, K. uye Li, F. Lipid-drug conjugate yekuwedzera kutengeswa kwezvinodhaka.Biochemistry 14, 1325-1338 (2017).
Torchilin VP Kufambira mberi kwazvino mumunda we liposomes sevatakuri vezvinodhaka.National Kuvhurwa kwemufundisi wezvinodhaka.4, 145–160 (2005).
Bhat, M., Jatyan, R., Mittal, A., Mahato, RI & Chitkara, D. Mikana nematambudziko emafuta acid conjugated therapeutics. Bhat, M., Jatyan, R., Mittal, A., Mahato, RI & Chitkara, D. Mikana nematambudziko emafuta acid conjugated therapeutics.Bhat, M., Jatyan, R., Mittal, A., Mahato, RI uye Chitkara, D. Mikana nematambudziko emafuta acid conjugated therapeutics. Bhat, M., Jatyan, R., Mittal, A., Mahato, RI & Chitkara, D. 脂肪酸共轭疗法的机遇和挑战. Bhat, M., Jatyan, R., Mittal, A., Mahato, RI & Chitkara, D. Fatty acid 共续电影的机遇和challenge.Bhat M., Jatyan R., Mittal A., Mahato RI uye Chitkara D. Mikana uye matambudziko emafuta acid conjugation therapy.Chemical.fizikisi Lipids 236, 105053 (2021).
Smith, R. & Tanford, C. Hydrophobicity yeketani refu n-alkyl carboxylic acids, sezvinoyerwa nekugoverwa kwavo pakati peheptane uye aqueous solutions. Smith, R. & Tanford, C. Hydrophobicity yeketani refu n-alkyl carboxylic acids, sezvinoyerwa nekugoverwa kwavo pakati peheptane uye aqueous solutions.Smith, R. naTanford, K. Hydrophobicity ye-long-chain n-alkylcarboxylic acids yakayerwa nekupararira kwayo pakati peheptane uye aqueous solutions. Smith, R. & Tanford, C. Smith, R. & Tanford, C. The hydrophobicity of 长链正alkylcarboxylate, inoyerwa nekugoverwa kwavo pakati pehydrogen peroxide neaqueous solution.Smith, R. naTanford, K. Hydrophobicity ye-long-chain n-alkylcarboxylic acids yakayerwa nekupararira kwayo pakati peheptane uye aqueous solutions.process.National Academy yeSainzi.sainzi US 70, 289 (1973).
Liu, J. nevamwe.Kamwe-vhiki nevhiki kuwanikwa kwemaglutide analog yeglucagon-like peptide-1 (GLP-1).J. Mushonga.Chemical.58, 7370–7380 (2015).Iri basa rinoratidza kekutanga mukana wekushandisa kamwe pasvondo fatty acid derivatization nzira.
Østergaard, S. et al.Mhedzisiro yePYY3-36 yemunhu dibasic fatty acid acylation pane mini-nguruve Y2 receptor basa uye hafu yeupenyu.sainzi.Chirevo 11, 21179 (2021).Ichi chinyorwa chinoratidza kukosha kwefatty acid chinzvimbo, linker uye kugadzikana kwemusana mukuvandudzika kwehafu-yehupenyu PYY analogs.
Ensenat-Vaser, R. et al.Kupinda kwema myristoylated peptides mhiri kwesero membrane kwakaonekwa zvakananga uchishandisa confocal fluorescence microscopy.IUBMB Hupenyu 54, 33–36 (2002).
Nelson, AR, Borland, L., Allbritton, NL & Sims, CE Myristoyl-yakavakirwa kutakura kwepeptides mumasero mapenyu. Nelson, AR, Borland, L., Allbritton, NL & Sims, CE Myristoyl-yakavakirwa kutakura kwepeptides mumasero mapenyu.Nelson AR, Borland L, Allbritton NL.uye Sims SE Peptide kutakura mumasero mhenyu kunobva pane myristoyl. Nelson, AR, Borland, L., Allbritton, NL & Sims, CE 基于肉豆蔻酰的肽转运到活细胞中. Nelson, AR, Borland, L., Allbritton, NL & Sims, CE.Nelson, AR, Borland, L., Albritton, NL.uye Sims, KE Kutakura kwemyristoyl-based peptides kupinda mumasero mapenyu.Biochemistry 46, 14771–14781 (2007).
Kabanov, AV, Levashov, AV & Alakhov, VY Lipid kugadziriswa kweprotein uye membrane yavo yekutakura. Kabanov, AV, Levashov, AV & Alakhov, VY Lipid kugadziriswa kweprotein uye membrane yavo yekutakura.Kabanov AV, Levashov AV, Alakhov V.Yu.Lipid shanduko yemapuroteni uye membrane yavo yekutakura. Kabanov, AV, Levashov, AV & Alakhov, VY 蛋白质的脂质修饰及其膜转运. Kabanov, AV, Levashov, AV & Alakhov, VYKabanov AV, Levashov AV, Alakhov, Lipid kugadziriswa kweVY mapuroteni uye membrane yavo yekutakura.protein engineering.Zvita Searl.3, 39–42 (1989).
Gao, X., Mazière, AD, Beard, R., Klumperman, J. & Hannoush, RN Fatty acylation inovandudza cellular internalization uye cytosolic kugoverwa kwe cystine-knot peptide. Gao, X., Mazière, AD, Beard, R., Klumperman, J. & Hannoush, RN Fatty acylation inovandudza cellular internalization uye cytosolic kugoverwa kwe cystine-knot peptide.Gao, X., Mazier, AD, Byrd, R., Klumperman, J. uye Hannoosh, RN Fatty acid acylation inovandudza cellular internalization uye cytosolic kugoverwa kwepeptide ine cystine loop. Gao, X., Mazière, AD, Beard, R., Klumperman, J. & Hannoush, RN 脂肪酰化增强了胱氨酸结肽的细胞内化和胞质分布. Gao, X., Mazière, AD, Beard, R., Klumperman, J. & Hannoush, RN.Gao, X., Mazier, AD, Byrd, R., Klumperman, J. uye Hannoosh, RN Fatty acylation inowedzera cellular internalization uye cytoplasmic kugoverwa kwe cystine peptides.iScience 24, 103220 (2021).
Baker, EM nevamwe.Hafu-yehupenyu-inorebesa shanduko yeYY3-36 peptide kune yakananga receptor-mediated internalization.Moore.mushonga.16, 3665–3677 (2019).
Mäde, V., Bellmann-Sickert, K., Kaiser, A., Meiler, J. & Beck-Sickinger, AG Nzvimbo uye urefu hwemafuta acids zvinokanganisa zvakanyanya receptor selectivity maitiro evanhu pancreatic polypeptide analogues. Mäde, V., Bellmann-Sickert, K., Kaiser, A., Meiler, J. & Beck-Sickinger, AG Nzvimbo uye urefu hwemafuta acids zvinokanganisa zvakanyanya receptor selectivity maitiro evanhu pancreatic polypeptide analogues.Yakagadzirwa, W., Bellmann-Sickert, K., Kaiser, A., Mailer, J. naBeck-Sickinger, AG Nzvimbo uye kureba kwemafuta acids zvinokurudzira zvakanyanya sarudzo yekusarudza kwevanhu pancreatic polypeptide analog receptors. Mäde, V., Bellmann-Sickert, K., Kaiser, A., Meil ​​er, J. & Beck-Sickinger, AG . Mäde, V., Bellmann-Sickert, K., Kaiser, A., Meiler, J. & Beck-Sickinger, AGYakagadzirwa, W., Bellmann-Sickert, K., Kaiser, A., Mailer, J. naBeck-Sickinger, AG Nzvimbo uye kureba kwemafuta acids zvinokurudzira zvakanyanya sarudzo yekusarudza kwevanhu pancreatic analog polypeptide receptors.HimMedChem 9, 2463–2474 (2014).
Aleksopoulou, F. et al.Iyo lipid metabolite PrRP31 ndeyekureba-inobata mbiri GPR10 uye NPFF2 receptor agonist ine simba rekurasikirwa nehuremu mhedzisiro.sainzi.Report 12, 1696 (2022).Ichi chidzidzo chemaitiro chinoratidza mutsauko pakati pemono- uye diacid parutivi cheni.
Poulsen, K. et al.Rational kuvandudza kweakagadzikana agonist eY2 receptor peptide PYY3-36.mushonga.tangi yekuchengetedza.38, 1369–1385 (2021).
Conde-Frieboes, K. et al.Kuzivikanwa uye hunhu hwe in vitro uye mu vivo analogues yeakareba-anoita uye anosarudza melanocortin 4 receptor (MC4-R) alpha-melanocyte-inosimudzira mahormone (alpha-MSH).J. Mushonga.Chemical.55, 1969–1977 (2012).
Ramirez-Andersen, HS et al.Kureba-kuita kwevanhu kukura kwehomoni analogues inosungirirwa kune isiri-covalent albumin.Bioconjugate.Chemical.29, 3129–3143 (2018).
Madsen, K. et al.Chimiro-chiitwa hukama uye kurebesa kweakarebesa inobata glucagon-yakafanana peptide-1 kubva: kukosha kwemafuta acid kureba, polarity, uye vhoriyamu.J. Mushonga.Chemical.50, 6126–6132 (2007).
Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Double-acylated GLP-1 derivatives. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Double-acylated GLP-1 derivatives. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Дважды ацилированные производные GLP-1. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Doubly acylated derivatives yeGLP-1. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. 双酰化GLP-1 衍生物. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. 双酰化GLP-1 衍生物. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Диацилированные производные GLP-1. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Diacylated derivatives yeGLP-1.US Patent WO2012/140117 (2012).
Mudiki, P.-Yu.Mira.Iine simba, yakareba-inobata GLP-1 analogis akagadzirirwa transdermal kuendesa zvichienderana neiyo microstructure.process.National Academy yeSainzi.sainzi.US 113, 4140–4145 (2016).
Royalty, JE. zvidzidzo. Royalty, JE. zvidzidzo.Royalty, JE, Konradsen, G., Eskerod, O., Wolf, BS naHansen, BS Kuchengetedzwa, kushivirira, pharmacokinetics, uye pharmacodynamics kudzidza kweimwe uye yakawanda madosi eakareba-anoita α-MSG analog mune hutano hwakanyanya kuwandisa uye hwakafuta zvidzidzo.版税, JE, Konradsen, G., Eskerod, O., Wulff, BS & Hansen, BS 单剂量和多剂量长效α-MSH受性、药代动力学和药效学研科目.版税, JE, Konradsen, G., Eskerod, O., Wulff, BS & Hansen, BS Single dosage and multi dosage long effect α-MSH 全健康超重和肥胖可以中可以可以而受滅药效学研究科目。Royalty, JE, Konradsen, G., Eskerod, O., Wolf, BS naHansen, BS Kuchengetedzwa, kushivirira, pharmacokinetics yeimwe uye yakawanda doses yeakareba-achiita alpha-MSG analogues mune hutano hwakanyanya kuwandisa uye hwakafuta zvidzidzo.Kinetics uye pharmacodynamics.J. Clin.Pharmacodynamics.54, 394–404 (2014).
Lau, J., F., Kruse, T., Linderoth, L. & Thøgersen, H. Novel glucagon analogues. Lau, J., F., Kruse, T., Linderoth, L. & Thøgersen, H. Novel glucagon analogues.Lau, J., F., Kruse, T., Linderoth, L. uye Togersen, H. Nyowani analogues eglucagon. Lau, J., F., Kruse, T., Linderoth, L. & Thøgersen, H. 新型胰高血糖素类似物。 Lau, J., F., Kruse, T., Linderoth, L. & Thøgersen, H.Lau, J., F., Cruz, T., Linderoth, L. uye Togersen, H. Nyowani glucagon analogues.US Patent WO2011/117416 A1 (2011).
Ward, BP et al.Lipidation ye peptides inodzikamisa zvimiro zvekusimudzira biological basa.Moore.metabolism.2, 468–479 (2013).Iri basa rinoratidza basa remafuta acid parutivi maketani mukuona kugadzikana kwechimiro uye kusunga kwepeptide drug receptors.
Koskun T. et al.LY3298176, inoveli mbiri GIP uye GLP-1 receptor agonist yekurapa kwerudzi rwechipiri chirwere cheshuga: kubva pakuwanikwa kusvika kukiriniki humbowo hwepfungwa.Moore.metabolism.18, 3-14 (2018).Iri bepa rinoratidza dhizaini yekutanga fatty acid-yakatorwa GLP-1/GIP co-agonist yekamwe-vhiki yekutonga mukiriniki.
Kjeldsen, TB et al.Molecular engineering ye icodec insulin, yekutanga kamwe-vhiki nevhiki acylated insulin analog muvanhu.J. Mushonga.Chemical.64, 8942–8950 (2021).Iri bepa rinopa yekutanga kuvandudzwa kwemafuta acid inotorwa insulin kamwe chete pasvondo kutonga.
van Witteloostein, SB nevamwe.Neoglycolipids yemapeptide akareba-anoita: kuzvibatanidza analogs eglucagon-like peptide 1 ine albumin-binding properties uye yakakwirira mu vivo potency.Moore.mushonga.14, 193–205 (2017).
Zorzi, A., Middendorp, SJ, Wilbs, J., Deyle, K. & Heinis, C. Acylated heptapeptide inosunga albumin nehukama hwepamusoro uye kushandiswa sezvo tag inopa peptides yakareba-inoshanda. Zorzi, A., Middendorp, SJ, Wilbs, J., Deyle, K. & Heinis, C. Acylated heptapeptide inosunga albumin nehukama hwepamusoro uye kushandiswa sezvo tag inopa peptides yakareba-inoshanda.Zorzi, A., Middendorp, SJ, Wilbs, J., Dale, K. uye Haynes, S. Acylated heptapeptide inosunga albumin nehupamhi hwepamusoro, uye kushandiswa kwayo sechinyorwa kunopa peptide yakareba kwenguva refu. Zorzi, A., Middendorp, SJ, Wilbs, J., Deyle, K. & Heinis, C. Zorzi, A., Middendorp, SJ, Wilbs, J., Deyle, K. & Heinis, C. 鎄化七peptide以高亲和力设计白白约筒，使用于设计手机。Zorzi, A., Middendorp, SJ, Wilbs, J., Dale, K. naHaynes, S. Acylated heptapeptides inosunga albumin nehukama hwepamusoro uye inoshanda semavara ekutumira peptide kwenguva refu.Nat.kutaurirana 8, 16092 (2017).