Linaclotide
Keywords
- LinaclotideBase
- mutengo unokwanisika zvakanyanya
- CAS# 851199-59-2
Quick Details
- ProName: Linaclotide
- CasNo: 851199-59-2
- Molecular Formula: C59H79N15O21S6
- Kuonekwa: chena poda
- Chikumbiro: inoshandiswa pakurapa kuvimbiswa
- DeliveryTime: kukurumidza kutumira
- PackAge: zvinoenderana nezvinodiwa nemutengi
- Port: Shenzhen
- ProductionCapacity: 1 Kilogram/Mwedzi
- Kuchena: 98%
- Kuchengetedza: 2 ~ 8 ℃. kudzivirirwa kubva kuchiedza
- Kutakura: nendege
- LimitNum: 1 Gram
Superiority
Details
Chigadzirwa: Linaclotide
Synonym: Linaclotide Acetate
Nhamba yeCAS: 851199-59-2
Molecular Formula: C59H79N15O21S6
Molecular uremu: 1526.8
Kuonekwa: White powder
Kuchena:> 98%
Sequence: NH2-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH
Linaclotide inogadzirwa, gumi nemana amino acid peptide uye agonist ye intestinal guanylate cyclase type C (GC-C), iyo ine hukama nemhuri yeguanylin peptide, ine secretagogue, analgesic uye laxative zviitiko. Pamusoro pekutonga nemuromo, linaclotide inosunga uye inomutsa GC-C receptors iri pamusoro pe luminal surface ye intestinal epithelium. Izvi zvinowedzera kuwanda kweiyo intracellular cyclic guanosine monophosphate (cGMP), iyo inotorwa kubva kuguanosine triphosphate (GTP). cGMP inomutsa cystic fibrosis transmembrane conductance regulator (CFTR) uye inomutsa kuburitswa kwechloride uye bicarbonate mumatumbo lumen. Izvi zvinokurudzira kubuda kwesodium mu lumen uye kunoguma nekuwedzera mumatumbo emvura secretion. Izvi pakupedzisira zvinomhanyisa GI transit yemukati yemukati, inovandudza bowel kufamba uye inobvisa kuvimbiswa. Kuwedzera extracellular cGMP mazinga anogonawo kuita antinociceptive effect, kuburikidza neasati anyatsojekeswa nzira, iyo inogona kusanganisira modulation ye nociceptors inowanikwa pa colonic afferent pain fibers. Linaclotide inotorwa zvishoma kubva muGI turakiti.
