Deivatization o ga'o ga'o i le mauaina o peptide ma polotini vaila'au

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Peptides ma polotini e masani ona faʻaaogaina e togafitia ai faʻamaʻi eseese, ae masani lava e tatau ona tui ma o latou aafiaga e puupuu.O nei faaletonu o fausaga moni e mafai ona faʻaumatia i le fesoasoani a le inisinia mole, ae o se galuega faigata.O metotia fa'ainisinia mole, na fa'aaogaina muamua i le inisalini ma o lea ua fa'aaoga lelei i le tele o biopharmaceuticals, e mana'omia ai le fa'atupuina o peptide ma polotini mai ga'o ga'o.O uiga ma'oti ma le nofoaga o ga'o fa'apipi'i e mafai ona maua ai ni faiga fa'alautele eseese.E le gata i lea, o lenei tekinolosi e mafai ona maua ai se afa umi o le ola pe a uma le tuʻuina atu o vailaʻau peptide, e ono suia ai le tufatufaina o peptides, ma e ono iai le malosi mo le faʻaogaina o le tino.Faatasi ai ma le saogalemu faʻapitoa o gaʻo gaʻo ma faʻamaʻi faʻamalamalama lelei, o lenei tekonolosi e maua ai se auala faʻapitoa i le suʻeina o vailaʻau peptide ma le polotini.
O tau uma o lo'o fa'amauina.Ole VAT ole a fa'aopoopo mulimuli ane ile fa'atau.Ole fa'atatauga ole lafoga ole a faia ile fa'atau.
Muttenthaler, M., Tupu, GF, Adams, DJ & Alewood, PF Fa'agasolo ile su'esu'eina o vaila'au peptide. Muttenthaler, M., Tupu, GF, Adams, DJ & Alewood, PF Fa'agasolo ile su'esu'eina o vaila'au peptide.Muttenthaler, M., King, GF, Adams, DJ ma Alevud, PF Trends i le suʻesuʻeina o vailaʻau peptide. Muttenthaler, M., Tupu, GF, Adams, DJ & Alewood, PF 多肽药物发现的趋势。 Muttenthaler, M., Tupu, GF, Adams, DJ & Alewood, PFMuttenthaler, M., King, GF, Adams, DJ ma Alevud, PF Trends i le suʻesuʻeina o vailaʻau peptide.National O le tatalaina o le faifeau fualaau faasaina.20, 309–325 (2021).O lenei iloiloga e taulaʻi i le taimi nei ma le lumanaʻi o le suʻesuʻeina o vailaʻau peptide.
Müller, TD, Blüher, M., Tschöp, MH & DiMarchi, RD Anti-obesity suʻesuʻega vailaʻau: alualu i luma ma luʻitau. Müller, TD, Blüher, M., Tschöp, MH & DiMarchi, RD Anti-obesity suʻesuʻega vailaʻau: alualu i luma ma luʻitau.Müller, TD, Blucher, M., Chop, MH ma DiMarchi, RD Anti-obesity suʻesuʻega vailaʻau: alualu i luma ma luitau. Müller, TD, Blüher, M., Tschöp, MH & DiMarchi, RD 抗肥胖药物发现：进展和挑战。 Müller, TD, Blüher, M., Tschöp, MH & DiMarchi, RDMüller, TD, Blucher, M., Chop, MH ma DiMarchi, RD Anti-obesity suʻesuʻega vailaʻau: alualu i luma ma luitau.National O le tatalaina o le faifeau fualaau faasaina.21, 201–223 (2022).O lenei iloiloga e maua ai se faʻamatalaga i faʻafitauli o le gaʻo, aemaise lava manatu fou e faʻavae i luga o peptides.
Strohl, WR Fusion polotini e fa'alautele ai le afa o le ola o meaola fa'apitoa e fai ma ta'iala sili mo meaola fa'aola.Biopharmaceutics 29, 215–239 ​​(2015).
Evans, M. et al.O le tausisia ma le faʻaauauina o vailaʻau faʻamaʻi ma faʻatasi ma taunuʻuga faʻapitoa ma le tamaoaiga i tagata mamaʻi e maua i le maʻisuka ituaiga 2: o se iloiloga faʻatulagaina o tusitusiga.ma'i suka puta.metabolism.24, 377–390 (2022).
Polonsky, WH, Fisher, L., Hessler, D., Bruhn, D. & Best, JH Va'aiga a le ma'i i vaila'au ta'itasi-vaiaso mo le ma'isuka. Polonsky, WH, Fisher, L., Hessler, D., Bruhn, D. & Best, JH Va'aiga a le ma'i i vaila'au ta'itasi-vaiaso mo le ma'isuka.Polonsky WH, Fisher L., Hessler D., Brune D., ma le Best JH O se vaaiga a le tagata maʻi i vailaʻau o le maʻisuka e tasi-vaiaso. Polonsky, WH, Fisher, L., Hessler, D., Bruhn, D. & Best, JH 患者对每周一次的糖尿病药物的看法。 Polonsky, WH, Fisher, L., Hessler, D., Bruhn, D. & Best, JHPolonsky WH, Fisher L., Hessler D., Brune D., ma le Best JH Mana'oga o tagata ma'i i vaila'au o le ma'isuka ta'i vaiaso.ma'i suka puta.metabolism.13, 144–149 (2011).
Hashimoto, M., Takada, K., Kiso, Y. & Muranishi, S. Fa'asologa o palmitoyl derivatives o le inisalini ma a latou gaioiga olaola. Hashimoto, M., Takada, K., Kiso, Y. & Muranishi, S. Fa'asologa o palmitoyl derivatives o le inisalini ma a latou gaioiga olaola.Hashimoto M., Takada K., Kiso Y. ma Muranishi S. Fa'asologa o palmitoyl derivatives o le inisalini ma a latou gaioiga olaola. Hashimoto, M., Takada, K., Kiso, Y. & Muranishi, S. 胰岛素棕榈酰衍生物的合成及其生物活性。 Hashimoto, M., Takada, K., Kiso, Y. & Muranishi, S. Faʻasologa ma gaioiga faʻaola ole insulin palmitoyl derivatives.Hashimoto M., Takada K., Kiso Y. ma Muranishi S. Fa'asologa ma gaioiga fa'aola ole insulin palmitoyl derivatives.faatanoa vailaau 6, 171–176 (1989).
Kurtzhals, P. et al.Albumin fusifusia i le ga'o ga'o-acylate inisalini: fa'ata'ita'iga o feso'ota'iga ligand-protein ma fa'amaopoopo i le va o feso'ota'iga fa'atasi ma le taimi fa'atino o le inisalini i vivo.biochem.J. 312, 725–731 (1995).O lenei galuega o le muamua lea na faʻaalia ai le faʻateleina o le afa-ola ona o le fusifusia o le albumin i peptides e maua mai i gaʻo gaʻo.
Mejuch, T. & Waldmann, H. Fa'asologa o polotini lipidated. Mejuch, T. & Waldmann, H. Fa'asologa o polotini lipidated.Meyukh, T. ma Waldmann, H. Fa'asologa o polotini lipidated. Mejuch, T. & Waldmann, H. 脂化蛋白质的合成。 Mejuch,T.& Waldmann,H.Meyukh, T. ma Waldmann, H. Fa'asologa o polotini lipidated.Bioconjugate.Kemisi.27, 1771–1783 (2016).
Chen, B., Sun, Y., Niu, J., Jarugumilli, GK & Wu, X. Protein lipidation i le cell signaling ma faʻamaʻi: galuega, tulafono faatonutonu, ma avanoa faʻapitoa. Chen, B., Sun, Y., Niu, J., Jarugumilli, GK & Wu, X. Protein lipidation i le cell signaling ma faʻamaʻi: galuega, tulafono faatonutonu, ma avanoa faʻapitoa.Chen B., Sun Y., Niu J., Jarugumilli GK ma Wu X. Protein lipidation in cell signaling and disease: function, regulation, and therapeutic potential. Chen, B., Sun, Y., Niu, J., Jarugumilli, GK & Wu, X. 细胞信号和疾病中的蛋白质脂化：功能、调节和治疗机。 Chen, B., Sun, Y., Niu, J., Jarugumilli, GK & Wu, X. Protein脂化 i le cell signaling ma faʻamaʻi: galuega, tulafono faatonutonu ma avanoa faʻapitoa.Chen B., Sun Y., Niu J., Jarugumilli GK ma Wu X. Protein lipidation in cell signaling and disease: function, regulation, and therapeutic potential.cytochemistry.biology 25, 817–831 (2018).
Richter, WF, Bhansali, SG & Morris, ME Mechanistic determinants of biotherapeutics absorption pe a uma le pulega SC. Richter, WF, Bhansali, SG & Morris, ME Mechanistic determinants of biotherapeutics absorption pe a uma le pulega SC.Richter, VF, Bhansali, SG ma Morris, ME Mechanisms e fuafua ai le faʻaogaina o vailaʻau biotherapeutic pe a uma le faʻaogaina o le subcutaneous. Richter, WF, Bhansali, SG & Morris, ME SC 给药后生物治疗药物吸收的机制决定因素。 Richter, WF, Bhansali, SG & Morris, ME SC Richter, WF, Bhansali, SG & Morris, ME SC Механистические детерминанты абсорбции биотерапевтических препаратов после введения. Richter, WF, Bhansali, SG & Morris, ME SC Fa'atonu fa'ainisinia o le fa'aogaina o vaila'au fa'aolaola pe a uma le fa'atonuga.AAPS J. 14, 559–570 (2012).
Gradel, AKJ et al.O a'afiaga e a'afia ai le fa'asa'oina o le inisalini i lalo o le pa'u: a'afiaga mo le fesuisuia'i.J. Ma'i suka Res.2018, 1205121 (2018).
Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. O le faʻasalalau ma le polymerization e fuafua ai le faʻaogaina o le inisalini mai le tino i lalo o le tino i tagata maʻi suka. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. O le faʻasalalau ma le polymerization e fuafua ai le faʻaogaina o le inisalini mai le tino i lalo o le tino i tagata maʻi suka. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L м. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. O le faʻasalalauina ma le polymerization e fuafua ai le faʻaogaina o le inisalini mai le tino i lalo o le tino i tagata maʻi suka. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L . Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. O le faʻasalalauina ma le faʻapipiʻiina e fuafua ai le faʻaogaina o le inisalini i lalo o le tino i tagata maʻi suka.su'esu'e.J. Klin.falesuesue.teu faafaigaluega.45, 685–690 (1985).
Mosekilde, E., Jensen, KS, Binder, C., Pramming, S. & Thorsteinsson, B. Fa'ata'ita'iga o le fa'aogaina o le inisalini soluble tui. Mosekilde, E., Jensen, KS, Binder, C., Pramming, S. & Thorsteinsson, B. Fa'ata'ita'iga o le fa'aogaina o le inisalini soluble tui.Mosekilde E, Jensen KS, Binder S, Pramming S, ma Thorsteinsson B. Fa'ata'ita'iina o le fa'aogaina o le inisalini soluble i lalo. Mosekilde, E., Jensen, KS, Binder, C., Pramming, S. & Thorsteinsson, B. 模拟皮下注射可溶性胰岛素的吸收动力学。 Mosekilde, E., Jensen, KS, Binder, C., Pramming, S. & Thorsteinsson, B.Mosekilde E, Jensen KS, Binder S, Pramming S, ma Thorsteinsson B. Fa'ata'ita'iina o le fa'aogaina o le inisalini soluble e tu'uina i lalo o le pa'u.J. Pharmacokinetics.biopharmacy.17, 67–87 (1989).
Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III Molecular size modulates pharmacokinetics, biodistribution, ma renal deposition of the drug delivery biopolymer elastin-like polypeptide. Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III Molecular size modulates pharmacokinetics, biodistribution, ma renal deposition of the drug delivery biopolymer elastin-like polypeptide. Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III Размер молекулы модулирует фармакокинетику, биораспределение и отложение в подление в подочиности ого полипептида для доставки лекарственного средства. Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III Molecular size modulates pharmacokinetics, biodistribution, ma renal deposition of biopolymeric elastin-like polypeptide mo le tuʻuina atu o fualaau. Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III.和肾脏沉积。 Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III MoleculeKuna, M., Mahdi, F., Chad, AR ma Bidwell, GL III.Pharmacokinetics, biodistribution ma renal deposition o biopolymeric elastin-pei polypeptides faʻaogaina le tele o le mole.Science Lipoti 8, 7923 (2018).
Harris, JM, Martin, NE & Modi, M. Pegylation: o se faiga fou mo le suia o vailaʻau faʻamaʻi. Harris, JM, Martin, NE & Modi, M. Pegylation: o se faiga fou mo le suia o vailaʻau faʻamaʻi. Harris, JM, Martin, NE & Modi, M. Пегилирование: новый процесс модификации фармакокинетики. Harris, JM, Martin, NE & Modi, M. Pegylation: o se faiga fou mo le suia o vailaʻau faʻamaʻi. Harris, JM, Martin, NE & Modi, M. 聚乙二醇化：一种改变药代动力学的新方法。 Harris, JM, Martin, NE & Modi, M. 聚乙二感化: o se auala fou e suia ai vailaau. Harris, JM, Martin, NE & Modi, M. Пегилирование: новый подход к изменению фармакокинетики. Harris, JM, Martin, NE & Modi, M. Pegylation: o se auala fou e suia ai pharmacokinetics.falema'i.Pharmacokinetics.40, 539–551 (2001).
Elmerer, M. et al.Fuaina o le albumin interstitial i maso skeletal o le tagata ma le tino e ala ile microperfusion tatala.Ioe.J. Physiology.endocrine.metabolism.278, E352-E356 (2000).
Nelson, J. et al.O le afa umi o le albumin i tagata e manaʻomia ai le C-terminus.fesootai.biology.3, 181 (2020).
Chowdhury, K. et al.O le Fc receptor (FcRn) mo le IgG e feso'ota'i ma le lavelave tele o le histocompatibility e fusifusia ai le albumin ma fa'aumi ai lona ola.J. Exp.vaila'au.197, 315–322 (2003).
Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES Exocytosis o IgG e pei ona faʻasalalau e le tali, FcRn: o se suʻesuʻega i le tulaga tasi-molole. Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES Exocytosis o IgG e pei ona faʻasalalau e le tali, FcRn: o se suʻesuʻega i le tulaga tasi-molole. Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES Экзоцитоз IgG, опосредованный рецептором FcRn: анализ на уровне одной молекулы. Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES FcRn receptor-mediated IgG exocytosis: suʻesuʻega tasi-mole. Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES 受体介导的IgG 胞吐作用，FcRn：单分子水平的分析。 Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, Экзоцитоз IgG, опосредованный рецептором ES, FcRn: анализ на уровне одной молеклы. Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES receptor-mediated IgG exocytosis, FcRn: suʻesuʻega tulaga mole mole tasi.faiga.National Academy of Science.le faasaienisi.US 101, 11076 (2004).
O ia, XM & Carter, DC Atomic fausaga ma kemisi o serum albumin tagata. O ia, XM & Carter, DC Atomic fausaga ma kemisi o serum albumin tagata.I luga, XM ma Carter, DC Atomic fausaga ma kemisi o serum albumin tagata. O ia, XM & Carter, DC 人血清白蛋白的原子结构和化学。 O ia, XM & Carter, DC.I luga, XM ma Carter, DC Atomic fausaga ma kemisi o serum albumin tagata.Natura 358, 209–215 (1992).
Curry, S., Mandelkow, H., Brick, P. & Franks, N. O le fausaga tioata o le albumin serum a le tagata ua faʻapipiʻiina ma le gaʻo gaʻo e faʻaalia ai se tufatufaga tutusa o nofoaga faʻapipiʻi. Curry, S., Mandelkow, H., Brick, P. & Franks, N. O le fausaga tioata o le albumin serum a le tagata ua faʻapipiʻiina ma le gaʻo gaʻo e faʻaalia ai se tufatufaga tutusa o nofoaga faʻapipiʻi.Curry S., Mandelkow H., Brick P. ma Franks N. O le fausaga tioata o le albumin serum tagata i le lavelave ma se gaʻo gaʻo o loʻo faʻaalia ai le tufatufaina atu o nofoaga fusifusia. Curry, S., Mandelkow, H., Brick, P. & Franks, N. Curry, S., Mandelkow, H., Brick, P. & Franks, N. O le fausaga tioata o le paʻepaʻe paʻepaʻe paʻepaʻe o le tagata ma faʻamaʻi gaʻo e faʻaalia ai se tufatufaga tutusa o nofoaga fusifusia.Curry S., Mandelkow H., Brick P. ma Franks N. O le fausaga tioata o le albumin serum o le tagata i le lavelave ma gaʻo gaʻo o loʻo faʻaalia ai le tufatufaina atu o nofoaga fusifusia.Nat.fausaga.biology 5, 827–835 (1998).O lenei pepa o loʻo tuʻuina atu ai le faʻavae faʻavae o le fusifusia o gaʻo gaʻo ile serum albumin.
Irby, D., Du, C. & Li, F. Lipid-fa'a'au'au fa'asaina mo le fa'aleleia o le tu'uina atu o vaila'au. Irby, D., Du, C. & Li, F. Lipid-fa'a'au'au fa'asaina mo le fa'aleleia o le tu'uina atu o vaila'au.Irby, D., Du, K. ma Li, F. Lipid-drug conjugates mo le faʻaleleia atili o vailaʻau. Irby, D., Du, C. & Li, F. Lipid-fualaau faʻatasi mo le faʻaleleia o le tuʻuina atu o fualaau. Irby, D., Du, C. & Li, F. Lipid-fualaau faʻatasi mo le faʻaleleia o le tuʻuina atu o fualaau.Irby, D., Du, K. ma Li, F. Lipid-drug conjugate mo le faʻaleleia atili o vailaʻau.Biochemistry 14, 1325–1338 (2017).
Torchilin VP Fa'agasolo lata mai i le fanua o liposomes e avea ma vaila'au.National O le tatalaina o le faifeau fualaau faasaina.4, 145–160 (2005).
Bhat, M., Jatyan, R., Mittal, A., Mahato, RI & Chitkara, D. Avanoa ma luʻitau o faʻamaʻi gaʻo faʻapipiʻiina togafitiga. Bhat, M., Jatyan, R., Mittal, A., Mahato, RI & Chitkara, D. Avanoa ma luʻitau o faʻamaʻi gaʻo faʻapipiʻiina togafitiga.Bhat, M., Jatyan, R., Mittal, A., Mahato, RI ma Chitkara, D. Avanoa ma luʻitau o faʻamaʻi gaʻo faʻapipiʻiina togafitiga. Bhat, M., Jatyan, R., Mittal, A., Mahato, RI & Chitkara, D. 脂肪酸共轭疗法的机遇和挑战。 Bhat, M., Jatyan, R., Mittal, A., Mahato, RI & Chitkara, D. Fatty acid 共续电影的机遇和 luitau.Bhat M., Jatyan R., Mittal A., Mahato RI ma Chitkara D. Avanoa ma luʻitau o faʻamaʻi faʻamaʻi gaʻo gaʻo.Kemisi.physics Lipid 236, 105053 (2021).
Smith, R. & Tanford, C. Hydrophobicity o filifili uumi n-alkyl carboxylic acids, e fuaina i lo latou tufatufaina i le va o vaifofo heptane ma vai. Smith, R. & Tanford, C. Hydrophobicity o filifili uumi n-alkyl carboxylic acids, e fuaina i lo latou tufatufaina i le va o vaifofo heptane ma vai.Smith, R. ma Tanford, K. Hydrophobicity of long-chain n-alkylcarboxylic acids e fuaina i lo latou tufatufaina i le va o vaifofo heptane ma vai. Smith, R. & Tanford, C. 长链正烷基羧酸的疏水性，通过它们在庚烷和水溶液之间的分布来测量。 Smith, R. & Tanford, C. O le hydrophobicity o le 长链正alkylcarboxylate, fuaina i lo latou tufatufaina i le va o le hydrogen peroxide ma le vai vai.Smith, R. ma Tanford, K. Hydrophobicity of long-chain n-alkylcarboxylic acids e fuaina i lo latou tufatufaina i le va o vaifofo heptane ma vai.faiga.National Academy of Sciences.faasaienisi US 70, 289 (1973).
Liu, J. et al.Fa'atasi-vaiaso le su'esu'eina o semaglutide analog ole glucagon-like peptide-1 (GLP-1).J. Fomai.Kemisi.58, 7370–7380 (2015).O lenei galuega o loʻo faʻaalia mo le taimi muamua le avanoa e faʻaaoga ai le faʻaaogaina o le fatty acid i le vaiaso.
Østergaard, S. et al.Aafiaga o le tagata PYY3-36 dibasic fatty acid acylation i luga ole laititi-puaa Y2 faʻaogaina gaioiga ma le afa-ola.le faasaienisi.Lipoti 11, 21179 (2021).O lenei tusiga o loʻo faʻaalia ai le taua o le faʻaogaina o le gaʻo gaʻo, fesoʻotaʻiga ma le mautu i tua i le atinaʻeina o analog PYY umi o le afa-ola.
Ensenat-Vaser, R. et al.O le fa'aogaina o peptide myristoylated i luga o le membrane cell na va'aia sa'o i le fa'aogaina o le microscopy fluorescence confocal.IUBMB Life 54, 33–36 (2002).
Nelson, AR, Borland, L., Allbritton, NL & Sims, CE Myristoyl-faʻavaeina felauaiga o peptides i sela ola. Nelson, AR, Borland, L., Allbritton, NL & Sims, CE Myristoyl-faʻavaeina felauaiga o peptides i sela ola.Nelson AR, Borland L, Allbritton NL.ma Sims SE Peptide felauaiga i sela ola e faavae i myristoyl. Nelson, AR, Borland, L., Allbritton, NL & Sims, CE 基于肉豆蔻酰的肽转运到活细胞中。 Nelson, AR, Borland, L., Allbritton, NL & Sims, CE.Nelson, AR, Borland, L., Albritton, NL.ma Sims, KE felauaiga o peptide faavae myristoyl i sela ola.Biochemistry 46, 14771–14781 (2007).
Kabanov, AV, Levashov, AV & Alakhov, VY Lipid suiga o polotini ma latou felauaiga membrane. Kabanov, AV, Levashov, AV & Alakhov, VY Lipid suiga o polotini ma latou felauaiga membrane.Kabanov AV, Levashov AV, Alakhov V.Yu.Suiga Lipid o polotini ma latou felauaiga membrane. Kabanov, AV, Levashov, AV & Alakhov, VY 蛋白质的脂质修饰及其膜转运。 Kabanov, AV, Levashov, AV & Alakhov, VYKabanov AV, Levashov AV, Alakhov, Lipid suiga o VY proteins ma latou felauaiga membrane.inisinia polotini.Tes. Searl.3, 39–42 (1989).
Gao, X., Mazière, AD, Beard, R., Klumperman, J. & Hannoush, RN Fatty acylation faʻaleleia le faʻaogaina o le cellular ma le tufatufaina atu o le cytosolic o se peptide cystine-knot. Gao, X., Mazière, AD, Beard, R., Klumperman, J. & Hannoush, RN Fatty acylation faʻaleleia le faʻaogaina o le cellular ma le tufatufaina atu o le cytosolic o se peptide cystine-knot.Gao, X., Mazier, AD, Byrd, R., Klumperman, J. ma Hannoosh, RN Fatty acid acylation faʻaleleia le faʻaogaina o le telefoni feaveaʻi ma le tufatufaina atu o le cytosolic o se peptide faʻatasi ai ma le cystine loop. Gao, X., Mazière, AD, Beard, R., Klumperman, J. & Hannoush, RN 脂肪酰化增强了胱氨酸结肽的细胞内化和胞质分布。 Gao, X., Mazière, AD, Beard, R., Klumperman, J. & Hannoush, RN.Gao, X., Mazier, AD, Byrd, R., Klumperman, J. ma Hannoosh, RN Fatty acylation faʻaleleia le faʻaogaina o le cellular ma le tufatufaina atu o le cytoplasmic o peptides cystine.iScience 24, 103220 (2021).
Baker, EM et al.Fa'afouga fa'afuafua o le afa-ola o le peptide YY3-36 mo le fa'aogaina sa'o o le tali-fa'asalalau.Moore.vaila'au.16, 3665–3677 (2019).
Mäde, V., Bellmann-Sickert, K., Kaiser, A., Meiler, J. & Beck-Sickinger, AG Tulaga ma le umi o ga'o ga'o e matua'i a'afia ai le fa'aogaina o le fa'ailoga o le tagata fa'atusa polypeptide pancreatic. Mäde, V., Bellmann-Sickert, K., Kaiser, A., Meiler, J. & Beck-Sickinger, AG Tulaga ma le umi o ga'o ga'o e matua'i a'afia ai le fa'aogaina o le fa'ailoga o le tagata fa'atusa polypeptide pancreatic.Faia, W., Bellmann-Sickert, K., Kaiser, A., Mailer, J. ma Beck-Sickinger, AG O le tulaga ma le umi o gaʻo gaʻo e matua aʻafia ai le filifiliga filifilia o tagata pancreatic polypeptide analog receptors. Mäde, V., Bellemann-Scketrt, k., Kasisi, A., Aair Er Mäde, V., Bellmann-Sickert, K., Kaiser, A., Meil​​er, J. & Beck-Sickinger, AGFaia, W., Bellmann-Sickert, K., Kaiser, A., Mailer, J. ma Beck-Sickinger, AG O le tulaga ma le umi o gaʻo gaʻo e matuaʻi aʻafia ai le filifiliga filifilia o tagata pancreatic analog polypeptide receptors.HimMedChem 9, 2463–2474 (2014).
Aleksopoulou, F. et al.O le lipid metabolite PrRP31 o le GPR10 ma le NPFF2 receptor agonist umi e galue ma le malosi o le pa'u o le mamafa.le faasaienisi.Lipoti 12, 1696 (2022).O lenei suʻesuʻega faʻapitoa e faʻamaonia ai le eseesega i le va o filifili itu e tasi ma le diacid.
Poulsen, K. et al.Fuafuaga faʻapitoa o agonists mautu o le Y2 receptor peptide PYY3-36.vaila'au.tane teu.38, 1369–1385 (2021).
Conde-Frieboes, K. et al.Fa'ailoaina ma fa'amatalaga o in vitro ma in vivo analogues o le umi e galue ma filifili le melanocortin 4 receptor (MC4-R) alpha-melanocyte-stimulating hormone (alpha-MSH).J. Fomai.Kemisi.55, 1969–1977 (2012).
Ramirez-Andersen, HS et al.O fa'ata'ita'iga o le homone tuputupu a'e umi o le tagata e fusia i le albumin e le-covalent.Bioconjugate.Kemisi.29, 3129–3143 (2018).
Madsen, K. et al.Faiga-gaoioiga sootaga ma le faʻalauteleina o le glucagon-pei o le peptide-1 faʻasolosolo umi: le taua o le umi o le gaʻo, polarity, ma le voluma.J. Fomai.Kemisi.50, 6126–6132 (2007).
Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Double-acylated GLP-1 fa'atupu. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Double-acylated GLP-1 fa'atupu. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Дважды ацилированные производные GLP-1. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Faalua acylated derivatives o GLP-1. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. 双酰化GLP-1 衍生物。 Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. 双酰化GLP-1 衍生物。 Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Диацилированные производные GLP-1. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Diacylated derivatives o GLP-1.US Pateni WO2012/140117 (2012).
Young, P.-Yu.Faatali.GLP-1 fa'ata'ita'iga malosi, fa'aumi ona fa'atulagaina mo le fa'auluina o le transdermal e fa'avae i luga ole microstructure.faiga.National Academy of Science.le faasaienisi.US 113, 4140–4145 (2016).
Royalty, JE, Konradsen, G., Eskerod, O., Wulff, BS & Hansen, BS Suʻesuʻega o le saogalemu, tolerability, pharmacokinetics, ma pharmacodynamics o tui tasi ma le tele o se analog α-MSH umi-gaioi i le mamafa mamafa ma le gaʻo. mataupu. Royalty, JE, Konradsen, G., Eskerod, O., Wulff, BS & Hansen, BS Suʻesuʻega o le saogalemu, tolerability, pharmacokinetics, ma pharmacodynamics o tui tasi ma le tele o se analog α-MSH umi-gaioi i le mamafa mamafa ma le gaʻo. mataupu.Royalty, JE, Konradsen, G., Eskerod, O., Wolf, BS ma Hansen, BS Saogalemu, tolerability, pharmacokinetics, ma pharmacodynamics suʻesuʻega o le tasi ma le tele o tui o le α-MSG analog umi i le soifua maloloina o le mamafa ma le mamafa.版税, JE, Konradsen, G., Eskerod, O., Wulff, BS & Hansen, BS 单剂量和多剂量长效α-MSH 类似物在健康超邍剂量和多剂量长效α-MSH 类似物在健康超釀和超、耐受性、药代动力学和药效学研究科目。版税, JE, Konradsen, G., Eskerod, O., Wulff, BS & Hansen, BS Totogi tasi ma le tele o fua ole a'afiaga umi ole α-MSH 全健康超重和肥胖可以中可以可以中可以可以中可以可以可以可以而而、和药效学研究科目。Royalty, JE, Konradsen, G., Eskerod, O., Wolf, BS ma Hansen, BS Saogalemu, tolerability, pharmacokinetics of single and multiple doses of long-acting alpha-MSG analogues in healthy overweight and obese subjects.Kinetics ma pharmacodynamics.J. Clin.Pharmacodynamics.54, 394–404 (2014).
Lau, J., F., Kruse, T., Linderoth, L. & Thøgersen, H. Novel glucagon analogues. Lau, J., F., Kruse, T., Linderoth, L. & Thøgersen, H. Novel glucagon analogues.Lau, J., F., Kruse, T., Linderoth, L. ma Togersen, H. New glucagon analogues. Lau, J., F., Kruse, T., Linderoth, L. & Thøgersen, H. 新型胰高血糖素类似物。 Lau, J., F., Kruse, T., Linderoth, L. & Thøgersen, H.Lau, J., F., Cruz, T., Linderoth, L. ma Togersen, H. New glucagon analogues.US Pateni WO2011/117416 A1 (2011).
Ward, BP et al.Lipidation o peptides faʻamautu fausaga e faʻaleleia galuega faʻaola.Moore.metabolism.2, 468–479 (2013).O lenei galuega o loʻo faʻaalia ai le matafaioi a le gaʻo gaʻo itu itu filifili i le fuafuaina o le faʻatulagaina mautu ma le fusia o peptide fualaau faʻasaina.
Koskun T. et al.LY3298176, o se tala fou GIP ma GLP-1 receptor agonist mo togafitiga o le maʻisuka ituaiga 2: mai le mauaina i le falemaʻi faʻamaoniga o manatu.Moore.metabolism.18, 3-14 (2018).O lenei pepa o loʻo tuʻuina atu ai le mamanu o le gaʻo gaʻo muamua na maua mai le GLP-1/GIP co-agonist mo le faʻatonuina i vaiaso taʻitasi i le falemaʻi.
Kjeldsen, TB et al.Inisinia mole mole ole icodec inisalini, o le muamua ta'i vaiaso acylated insulin analog i tagata.J. Fomai.Kemisi.64, 8942–8950 (2021).O lenei pepa o loʻo tuʻuina atu ai le atinaʻe muamua o le gaʻo gaʻo e maua mai le inisalini mo le faʻaaogaina i vaiaso taʻitasi.
van Witteloostein, SB et al.Neoglycolipids mo peptides umi-gaioi: fa'apipi'i e le tagata lava ia o le glucagon-pei o le peptide 1 fa'atasi ai ma mea e fusifusia ai albumin ma maualuga i vivo malosi.Moore.vaila'au.14, 193–205 (2017).
Zorzi, A., Middendorp, SJ, Wilbs, J., Deyle, K. & Heinis, C. Acylated heptapeptide e fusifusia ai albumin ma le maualuga o le vavalalata ma le faʻaogaina e pei o le tag e tuʻuina atu ai peptides umi. Zorzi, A., Middendorp, SJ, Wilbs, J., Deyle, K. & Heinis, C. Acylated heptapeptide e fusifusia ai albumin ma le maualuga o le vavalalata ma le faʻaogaina e pei o le tag e tuʻuina atu ai peptides umi.Zorzi, A., Middendorp, SJ, Wilbs, J., Dale, K. ma Haynes, S. Acylated heptapeptide e fusifusia ai le albumin ma le maualuga maualuga, ma o lona faʻaogaina o se igoa e maua ai se peptide umi. Zorzi, A., Middendorp, SJ, Wilbs, J., Deyle, K. & Heinis, C. Zorzi, A., Middendorp, SJ, Wilbs, J., Deyle, K. & Heinis, C.Zorzi, A., Middendorp, SJ, Wilbs, J., Dale, K. ma Haynes, S. Acylated heptapeptides faʻapipiʻi le albumin ma le maualuga maualuga ma avea ma faʻailoga mo le tuʻuina atu o peptide umi.Nat.fesootai 8, 16092 (2017).