Linaclotide
upu autu
- LinaclotideFa'avae
- tau sili ona taugofie
- CAS # 851199-59-2
Fa'amatalaga vave
- ProName: Linaclotide
- Kase Numera: 851199-59-2
- Fuafuaga mole: C59H79N15O21S6
- Fa'aaliga: pa'epa'e pa'epa'e
- Fa'aoga: fa'aaogaina mo le fa'amaloloina o le manava
- DeliveryTime: lafo vave
- PackAge: e tusa ai ma manaoga o tagata faatau
- Taulaga: Shenzhen
- Gaosia Gaosi: 1 Kilogram/Masina
- Mama: 98%
- Teuina: 2~8 ℃. puipuia mai le malamalama
- Felauaiga: i le ea
- LimitNumera: 1 Gram
Fa'asilisili
Fa'amatalaga
Oloa: Linaclotide
Synonym: Linaclotide Acetate
Numera CAS: 851199-59-2
Fuafuaga mole: C59H79N15O21S6
Malosi mole: 1526.8
Fa'aaliga: Pa'epa'e pa'epa'e
Mama: >98%
Fa'asologa: NH2-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH
Linaclotide o se synthetic, sefulufa amino acid peptide ma agonist o intestinal guanylate cyclase ituaiga C (GC-C), lea e structurally fesootai ma le guanylin peptide aiga, faatasi ai ma secretagogue, analgesic ma laxative gaoioiga. I luga o le tautala tautala, linaclotide e fusifusia ma faʻagaoioia GC-C faʻafeiloaʻi o loʻo i luga o le luminal surface o le intestinal epithelium. O lenei mea e faʻateleina ai le faʻaogaina o le intracellular cyclic guanosine monophosphate (cGMP), lea e maua mai le guanosine triphosphate (GTP). cGMP fa'agaoioia le cystic fibrosis transmembrane conductance regulator (CFTR) ma fa'aosofia ai le fa'alilo o le chloride ma le bicarbonate i totonu o le intestinal lumen. O le mea lea e fa'aolaina ai le alu o le sodium i totonu o le lumen ma fa'atupu ai le fa'atuputeleina o le sua o le intestinal. E i'u ina fa'atelevave le GI felauaiga o mea o lo'o i totonu o le intestinal, fa'aleleia le ga'o o le manava ma fa'amama ai le manava. O le faateleina o le maualuga o le cGMP e mafai foi ona maua ai se aafiaga antitinociceptive, e ala i se masini e leʻi atoatoa ona faʻamalamalamaina, e ono aʻafia ai le faʻaogaina o nociceptors o loʻo maua i luga o alava tiga o le colonic afferent. Linaclotide e itiiti lava le mitiia mai le GI tract.
