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Monomethylauristatin F （MMAF）
Chemical Name: (S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoic acid Molecular Weight: 731.96 Formula: C39H65N5O8 CAS#: 141205-32-5 Solubility: DMSO up to 20 mM Biological Activity Monomethyl auristatin F (MMAF) or desmethyl-auristatin F is an anti-tubulin agent that inhibits cell division by blocking the polymerization of tubulin. It is a ... -
Monomethyl Auristatin E (MMAE)
Chemical Name: (S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide Molecular Weight: 717.98 Formula: C39H67N5O7 CAS: 474645-27-7 Solubility: DMSO up to 20 mM Monomethyl Auristatin E is a dolastatin-10 peptide derivative with potent antimitotic activity and potential antineoplastic activity as part of an antibody...