Mu Meyi 2022, Shenzhen JYMed Technology Co., Ltd. (pambuyo pake amatchedwa JYMed peptide) idapereka peptidi yolembetsa semaglutide API ku US Food and Drug Administration (FDA) (nambala yolembetsa ya DMF: 036009), Yadutsa kuwunikanso umphumphu, ndipo pomwe pano ndi "A". JYMed peptide yakhala imodzi mwamagulu oyamba opanga semaglutide API ku China kuti apereke ndemanga ya US FDA.

Pa February 16, 2023, tsamba lovomerezeka la Drug Evaluation Center la State Drug Administration lidalengeza kuti semaglutide API [nambala yolembetsa: Y20230000037] yolembetsedwa ndikulengezedwa ndi Hubei JXBio Co., Ltd., wothandizira wa JYMed peptide, wapeza kuvomereza. JYMed peptide yakhala imodzi mwazopanga zopangira mankhwala oyamba omwe ntchito yawo yotsatsa izi idalandiridwa ku China.

Za semaglutide
Semaglutide ndi GLP-1 receptor agonist yopangidwa ndi Novo Nordisk (Novo Nordisk). Mankhwalawa amatha kukulitsa kagayidwe ka glucose polimbikitsa ma cell a pancreatic β kuti atulutse insulin, ndikuletsa katulutsidwe ka glucagon kuchokera ku maselo a pancreatic α kuti achepetse kusala komanso shuga wamagazi a postprandial. Kuonjezera apo, amachepetsa kudya mwa kuchepetsa chilakolako cha kudya ndi kuchepetsa chimbudzi m'mimba, zomwe pamapeto pake zimachepetsa mafuta a thupi ndikuthandizira kuchepetsa thupi.
1. Zambiri zoyambira
Kuchokera pamawonekedwe, poyerekeza ndi liraglutide, kusintha kwakukulu kwa semaglutide ndikuti ma AEEA awiri awonjezedwa pamzere wam'mbali wa lysine, ndipo palmitic acid yasinthidwa ndi octadecanedioic acid. Alanine adasinthidwa ndi Aib, yomwe idakulitsa kwambiri theka la moyo wa semaglutide.

Chithunzi Mapangidwe a semaglutide

2. Zizindikiro
1) Semaglutide ikhoza kuchepetsa chiopsezo cha zochitika zamtima kwa odwala omwe ali ndi T2D.
2) Semaglutide imachepetsa shuga m'magazi mwa kulimbikitsa kutsekemera kwa insulini komanso kuchepetsa kutsekemera kwa glucagon. Shuga m'magazi akakwera, kutulutsa kwa insulin kumalimbikitsidwa ndipo katulutsidwe ka glucagon kumalepheretsa.
3) Mayesero achipatala a Novo Nordisk PIONEER adawonetsa kuti oral administration of semaglutide 1mg, 0.5mg ili ndi zotsatira zabwino za hypoglycemic ndi zolemetsa kuposa Trulicity (dulaglutide) 1.5mg, 0.75mg.
3) Oral semaglutide ndi lipenga la Novo Nordisk. Kuwongolera pakamwa kamodzi patsiku kumatha kuchotsa zovuta komanso kuzunzika kwamaganizidwe komwe kumachitika chifukwa cha jakisoni, ndipo ndibwino kuposa liraglutide (jekeseni kamodzi pa sabata). Zotsatira za hypoglycemic ndi kuonda kwamankhwala odziwika bwino monga empagliflozin (SGLT-2) ndi sitagliptin (DPP-4) ndizowoneka bwino kwa odwala ndi madotolo. Poyerekeza ndi mapangidwe a jekeseni, mapangidwe a pakamwa angathandize kwambiri kuti pakhale chithandizo chamankhwala cha semaglutide.

3. Mwachidule
Ndi chifukwa cha ntchito yake yabwino kwambiri mu hypoglycemic, kuchepa thupi, chitetezo ndi ubwino wa mtima umene semaglutide yakhala "nyenyezi yatsopano" yodabwitsa yomwe ili ndi chiyembekezo chachikulu cha msika.