Mankhwala: Linaclotide
Mawu ofanana: Linaclotide Acetate
Nambala ya CAS: 851199-59-2
Molecular formula: C59H79N15O21S6
Kulemera kwa Molecular: 1526.8
Maonekedwe: ufa woyera
Chiyero:> 98%
Zotsatira: NH2-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH

Linaclotide ndi synthetic, khumi ndi zinayi amino acid peptide ndi agonist wa intestinal guanylate cyclase mtundu C (GC-C), amene structural zokhudzana ndi banja guanylin peptide, ndi secretagogue, analgesic ndi mankhwala ofewetsa tuvi tolimba ntchito. Pambuyo pakamwa, linaclotide imamangiriza ndikuyambitsa GC-C zolandilira zomwe zili pamtunda wa epithelium yamatumbo. Izi zimawonjezera kuchuluka kwa intracellular cyclic guanosine monophosphate (cGMP), yomwe imachokera ku guanosine triphosphate (GTP). cGMP imayendetsa cystic fibrosis transmembrane conductance regulator (CFTR) ndipo imathandizira kutulutsa kwa chloride ndi bicarbonate mu lumen yamatumbo. Izi zimathandizira kutuluka kwa sodium mu lumen ndipo kumapangitsa kuti matumbo achuluke kwambiri. Izi zimathandizira kuti GI yodutsa m'matumbo ikhale yabwino, imathandizira kuyenda kwamatumbo ndikuchotsa kudzimbidwa. Kuwonjezeka kwa extracellular cGMP milingo ingakhalenso ndi antinociceptive effect, kupyolera mu njira yosadziŵika bwino, yomwe ingaphatikizepo kusintha kwa ma nociceptors omwe amapezeka pamtundu wopweteka wa colonic afferent. Linaclotide imatengedwa pang'ono kuchokera ku thirakiti la GI.