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Monomethylauristatin F (MMAF)
Isem Kimiku: (S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-dimetil-2-((S) -3-methyl-2-(methylamino)butanamido) iżda anamido)-3-metossi-5-metileptanoil)pirrolidin-2-il)-3-metossi-2-metilpropanamido)-3-fenilpropanoiku aċidu Piż Molekulari: 731.96 Formula: C39H65N5O8 CAS#: 141205-32-5 Solubilità: DMSO sa 20 mM Attività Bijoloġika Monomethyl auristatin F (MMAF) jew desmethyl-auristatin F huwa aġent kontra t-tubulina li jinibixxi d-diviżjoni taċ-ċelluli billi jimblokka l-polimerizzazzjoni tat-tubulina. Huwa... -
Monometil Auristatin E (MMAE)
Isem Kimiku: (S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-idrossi-1-fenilpropan-2 -il)amino)-1-metossi-2-metil-3-ossopropil)p yrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide Piż molekulari: 717.98 Formula: C39H67N5O7 CAS: 474645-27-7 Solubilità: DMSO sa 20 mM Monomethyl Auristatin E huwa derivat tal-peptide dolastatin-10 b'attività antimitotika qawwija u attività antineoplastika potenzjali bħala parti minn antikorp...