Hua: Linaclotide
Taurite: Linaclotide Acetate
Nama CAS : 851199-59-2
Tātai rāpoi: C59H79N15O21S6
Taumaha rāpoi: 1526.8
Te ahua: Te paura ma
Maamaa: >98%
Raupapa: NH2-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH

Ko te Linaclotide he waihanga, tekau ma wha te waikawa amino peptide me te agonist o te intestinal guanylate cyclase momo C (GC-C), e hono ana ki te whanau peptide guanylin, me nga mahi huna, analgesic me te laxative. I runga i te whakahaere waha, ka herea e te linaclotide me te whakahohe i nga kaiwhakawhiwhi GC-C kei runga i te mata maramara o te epithelium intestinal. Ka whakanui ake tenei i te kukū o te guanosine monophosphate (cGMP), i ahu mai i te guanosine triphosphate (GTP). Ka whakahohehia e te cGMP te CFTR o te cystic fibrosis transmembrane conductance regulator (CFTR) me te whakaihiihi i te whakamaaramatanga o te chloride me te bicarbonate ki roto i te lumen intestinal. Ka whakatairanga tenei i te konutai ki roto i te lumen, ka nui ake te rere o te wai intestinal. I te mutunga ka whakaterehia te whakawhiti GI o nga ihirangi whekau, ka pai ake te korikori whekau me te whakamau i te paopao. Ko te piki ake o nga taumata cGMP extracellular pea ka whai paanga antinociceptive, na roto i te tikanga kaore ano kia tino whakamaramatia, ka uru pea ki te whakarereketanga o nga nociceptors ka kitea i runga i nga muka mamae o te koroni. Ko te Linaclotide he iti noa te whakauru mai i te waahanga GI.