Chemical nomen: (S) -n - ((3r, 4s, 5s) -1 - ((s) -2 - (((1, 2r) -1-I-(1, Phenylpropan -yl) amino) -1-metthoxy-II-y-y-oxopropyl) p Yrrolidin-I-YL) -3-Mthoxy-V-methyl-I-Oxohepan-IV-YL) -n, III-Dimethyl, II - ((s) -3-methyl-II ((Methylamino) Butanamido) Butanamide
M. pondus: 717,98
Formula: C39H67N5O7
CAS: 474645-27-7
Solubility: DMSO usque ad XX mm

Monomethyl Auristatin E estDolasteatin-XPeptide derivative cum potentia antimitotic actio et potentiale antinelastic actionem ut pars an antibody, medicamento coniugatam (ADC). Monomethyl auristatin E (Mme) Ligat ad tubulin, cuneos tubulin polymerization, et inhibits microtubule formatio, quae praecessi in utroque disrumpam mitotic fusum ecclesiam et comprehensionem tincidunt cellulis in m tempus cellula cycle. Ut minimize toxicity et maximize efficaciam,MmeConiungitur, per cleavable peptide linker, ad monoclonal antibody, ut specie peltas a patientes estote in tumore. In Linker est firmum in extracellular Milieu sed facile adhaesit dimittereMmePost binding et internalization ad ADC per scopum cellulis.