Nomen chemicum: (S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2 -yl)amino)-1-methoxy-2-methyl-3-oxopropyl)p yrrolidin-1-yl) -3-methoxy-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide
Molecular pondus: 717.98
Formula: C39H67N5O7
CAS: 474645-27-7
Solubilitas: DMSO usque ad XX mM

Monomethyl Auristatin E est adolastatin-10peptide derivativa cum potente activitate antimitotica et actui antineoplastico potentiali ut pars antibody-medicamentorum conjugatorum (ADC). Monomethyl auristatin E (MMAE) ligamenta ad tubulin, cuneos polymerizationem tubulin et microtubule formationem vetat, quae sequitur in utroque coetu fusi mitotici distractionem et comprehensionem cellularum tumoris in M ​​periodo cycli cellulae. Ad minimize toxicity et efficaciam augere;MMAEconiugatur, per nexus peptidis fissilis, anticorpus monoclonale quod speciei tumorem patientis peltat. Vinculum firmum est in ambitu extracellulari sed facile ad emissionem adhaesitMMAEsequuntur ligamen et internumizationem ADC per cellulas scopo.