Product Linaclotide
Synonym: linaclotide acetate
Cas No.: 851199-59-2
Molecular Formula: C59H79N15O21S6
M. pondus: 1526,8
Specie Alba pulveris
Puritas:> XCVIII%
Sequence: NH2-CYS-CYS-GLU, Tyrannis, CYS-CYS-ASN, Pro-ALY-CYS-Thre-SH TRYS-CYR

Linaclotide est synthetica, quattuordecim amino acidum peptide et Agonist de intestinorum Guanylate Cyclase Type C (GC-C), quod est structuram ad Guanysic peptide familia, cum secretagogue ad Guanysic peptide familia, cum secretagogue, analgesic et alvum actiones. In oris administratione, Linaclotide ligat et operatur Gc-c Receptatores sita in luminal superficies intestinorum epithelium. Hoc crescit concentration of Intracellular Cyclic Guanosine Monophosphate (CGMP), quae ex Guanosine Triphosphate (GTP). CGMP operatur in cystic fibrosis transmembrane conductance regulator (CFTR) et incitat ad secretionem chloride et bicarbonate in intestinorum lumen. Hoc promovet sodium excretion in lumen et eventus augeri intestinorum fluidum secretio. Hoc ultimately accelerat Gi transit intestinorum contenta, amplio alvum motus et relieves constipation. Auxit extracellular CGMP campester potest etiam exercent an antinocericeptive effectus, per quod sicut tamen non plene elucidated mechanism, ut involvere modulation of Nociceptors invenitur in colonic afferent dolor fibris. Linaclotide est minime absorbuit a Gi tractu.