Linaclotide
Okwu
- LinaclotideNtọala
- kacha ọnụ price
- CAS # 851199-59-2
Nkọwa ngwa ngwa
- Aha njirimara: Linaclotide
- Nọmba ekwentị: 851199-59-2
- Usoro ihe omimi: C59H79N15O21S6
- Ọdịdị: ọcha ntụ ntụ
- Ngwa: eji agwọ afọ ntachi
- Oge nzipu: mbupu ngwa ngwa
- PackAge: dị ka ndị ahịa chọrọ
- Port: Shenzhen
- Ike mmepụta: 1 Kilogram / ọnwa
- Ịdị ọcha: 98%
- Nchekwa: 2 ~ 8 ℃. echebe site na ìhè
- Ụgbọ njem: site na ikuku
- Ọnụ ọgụgụ: 1 gram
Nke kacha elu
Nkọwa
Ngwaahịa: Linaclotide
Synonym: Linaclotide Acetate
Nọmba CAS: 851199-59-2
Usoro ihe omimi: C59H79N15O21S6
Arọ Molecular: 1526.8
Ọdịdị: White ntụ ntụ
Ịdị ọcha:>98%
Usoro: NH2-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH
Linaclotide bụ ihe sịntetik, peptide iri na anọ amino acid na agonist nke eriri afọ guanylate cyclase ụdị C (GC-C), nke na-arụkọ ọrụ na ezinụlọ guanylin peptide, na secretagogue, analgesic na laxative omume. Mgbe nchịkwa ọnụ, linaclotide na-ejikọta ma rụọ ọrụ GC-C nnabata nke dị n'elu luminal nke epithelium intestinal. Nke a na-abawanye ntinye nke intracellular cyclic guanosine monophosphate (cGMP), nke sitere na guanosin triphosphate (GTP). cGMP na-arụ ọrụ cystic fibrosis transmembrane conductance regulator (CFTR) ma na-akpali nzuzo nke chloride na bicarbonate n'ime eriri afọ lumen. Nke a na-akwalite mmịpụta sodium n'ime lumen ma na-ebute mmụba nke mmiri mmiri nke eriri afọ. Nke a na-emesị mee ngwa ngwa GI nke ọdịnaya eriri afọ, na-eme ka eriri afọ dịkwuo mma ma na-ebelata afọ ntachi. Mmụba ọkwa cGMP extracellular extracellular nwekwara ike nwee mmetụta antinociceptive, site na usoro a na-akọwabeghị nke ọma, nke nwere ike ịgụnye mgbanwe nke nociceptors achọtara na eriri afọ mgbu nke colonic. A na-etinye Linaclotide obere na traktị GI.
