Non chimik:(S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-dimethyl-2-((S) -3-methyl-2-(methylamino)butanamido) men anamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoic asid

Pwa molekilè:731,96
Fòmil:C39H65N5O8
CAS #:141205-32-5
Solibilite:DMSO jiska 20 mM

Aktivite byolojik
Monomethyl auristatin F (MMAF) oswa desmethyl-auristatin F se yon ajan anti-tubulin ki anpeche divizyon selilè pa bloke polymerization tubulin. Li se yon nouvoauristatin deriveak yon phenylalanine chaje C-tèminal ki diminye aktivite cytotoxik li yo konpare ak kontrepati san chaj li yo, monomethyl auristatin E (MMAE). Anplis de sa, gwoup amine N-tèminal la gen sèlmanyounsubstituent methyl olye de de tankou nanauristatin Ftèt li.