Non chimik:(S) -2-((2r, 3r) -3-((s) -1-((3r, 4s, 5s) -4-((s) -n, 3-dimethyl-2-((s) -3-methyl-2- (methylamino) butanamido) men anamido) -3-methoxy-5-methylheptanoyl) pyrrolidin-2-il) -3-metoksi-2-methylpropanamido) -3-phenylpropanoic asid

Pwa molekilè:731.96
Fòmil:C39H65N5O8
CAS#:141205-32-5
Solubility:DMSO jiska 20 mm

Aktivite byolojik
Monometil auristatin F (MMAF) oswa desmethyl-auristatin F se yon ajan anti-tubulin ki inibit divizyon selilè pa bloke polimerizasyon nan tubulin. Li se yon nouvoauristatin deriveAvèk yon chaje C-tèminal fenilalanin ki diminye aktivite sitotoksik li yo konpare ak kontrepati uncharged li yo, monometil auristatin E (MMAE). Anplis de sa, N-tèminal gwoup la amine gen sèlmanyounnmetil substituan olye de de kòm nanauristatin ftèt li.