Thaum lub Tsib Hlis 2022, Shenzhen JYMed Technology Co., Ltd. (tom qab no hu ua JYMed peptide) tau xa daim ntawv thov rau npe ntawm semaglutide API rau US Food and Drug Administration (FDA) (DMF sau npe tus lej: 036009), Nws tau dhau los. Kev tshuaj xyuas kev ncaj ncees, thiab cov xwm txheej tam sim no yog "A". JYMed peptide tau dhau los ua ib qho ntawm thawj pawg ntawm semaglutide API manufacturers hauv Suav teb kom dhau US FDA tshuaj xyuas.

Thaum Lub Ob Hlis 16, 2023, lub vev xaib raug cai ntawm Lub Tsev Kawm Tshuaj Ntsuam Xyuas Tshuaj ntawm Lub Xeev Lub Chaw Tswj Tshuaj Tshuaj tau tshaj tawm tias semaglutide API [tus lej sau npe: Y20230000037] sau npe thiab tshaj tawm los ntawm Hubei JXBio Co., Ltd., ib lub koom haum ntawm JYMed peptide, tau txais txais. JYMed peptide tau dhau los ua ib qho ntawm thawj cov khoom lag luam raw khoom uas nws daim ntawv thov kev lag luam rau cov khoom no tau txais hauv Suav teb.

Hais txog semaglutide
Semaglutide yog GLP-1 receptor agonist tsim los ntawm Novo Nordisk (Novo Nordisk). Cov tshuaj tuaj yeem nce cov piam thaj metabolism los ntawm kev txhawb nqa pancreatic β hlwb kom zais cov tshuaj insulin, thiab inhibit qhov tso tawm ntawm glucagon los ntawm pancreatic α hlwb kom txo qis kev yoo mov thiab postprandial ntshav qab zib. Tsis tas li ntawd, nws txo qis kev noj zaub mov los ntawm kev txo qis qab los noj mov thiab qeeb qeeb hauv plab, uas thaum kawg txo lub cev rog thiab pab kom poob phaus.
1. Cov ntaub ntawv yooj yim
Los ntawm cov qauv kev pom, piv nrog liraglutide, qhov kev hloov pauv loj tshaj ntawm semaglutide yog tias ob lub AEEAs tau ntxiv rau sab saw ntawm lysine, thiab palmitic acid tau hloov los ntawm octadecanedioic acid. Alanine tau hloov los ntawm Aib, uas txuas ntxiv ib nrab-lub neej ntawm semaglutide.

Daim duab Structure ntawm semaglutide

2. Cov lus qhia
1) Semaglutide tuaj yeem txo qhov kev pheej hmoo ntawm cov kab mob plawv hauv cov neeg mob T2D.
2) Semaglutide txo cov ntshav qab zib los ntawm kev txhawb nqa cov tshuaj insulin secretion thiab txo qis glucagon secretion. Thaum cov piam thaj hauv ntshav siab, insulin secretion yog stimulation thiab glucagon secretion yog inhibited.
3) Novo Nordisk PIONEER kev soj ntsuam kuaj pom tau hais tias qhov ncauj tswj hwm ntawm semaglutide 1mg, 0.5mg muaj cov nyhuv hypoglycemic zoo dua thiab hnyav dua li Trulicity (dulaglutide) 1.5mg, 0.75mg.
3) Qhov ncauj semaglutide yog daim trump card ntawm Novo Nordisk. Kev tswj qhov ncauj ib hnub ib zaug tuaj yeem tshem tawm qhov tsis yooj yim thiab kev tsim txom ntawm kev puas siab puas ntsws los ntawm kev txhaj tshuaj, thiab nws zoo dua liraglutide (txhaj tshuaj ib zaug ib lub lim tiam). Cov teebmeem hypoglycemic thiab poob phaus ntawm cov tshuaj tseem ceeb xws li , empagliflozin (SGLT-2) thiab sitagliptin (DPP-4) yog qhov txaus nyiam rau cov neeg mob thiab kws kho mob. Piv nrog rau kev txhaj tshuaj formulations, qhov ncauj formulations yuav zoo heev txhim kho qhov yooj yim ntawm kev kho mob daim ntawv thov ntawm semaglutide.

3. Cov ntsiab lus
Nws yog qhov tseeb vim tias nws qhov kev ua tau zoo hauv hypoglycemic, poob phaus, kev nyab xeeb thiab cov txiaj ntsig ntawm cov hlab plawv uas semaglutide tau dhau los ua qhov tshwm sim-theem "lub hnub qub tshiab" nrog rau kev lag luam loj loj.